EZH2 Mouse, Unlabeled, Clone: 11, BD

Description

• The 11/EZH2 monoclonal antibody specifically binds to the methyltransferase, EZH2 (Enhancer of Zeste Homolog 2)
• EZH2 is a human homologue of Drosophila's Enhancer of zeste gene, an important regulator of homeobox gene expression
• The EZH2 protein has a predicted molecular weight of ∼85 kDa
• EZH2 is a member of the Polycomb group (PcG) of proteins that are essential for the maintenance, but not initiation, of the transcriptionally repressed state of certain developmental genes
• PcG proteins are a structurally diverse group of proteins with conserved functions from fly to human cells
• PcG family proteins form multimeric complexes that regulate the expression of genes involved in cell cycle, DNA repair and differentiation
• Specifically, EZH2 is a core enzymatic component of PRC2 (polycomb repressive complex 2)
• EZH2 is expressed in some lymph node follicular T cells and B cells
• Thymocytes differentially express EZH2 at various stages during T-cell maturation
• EZH2 interacts with multiple signaling proteins, including Vav, that are involved in lymphocyte development and activation
• It is highly expressed in a variety of tumors including lymphomas as well as breast and prostate cancers
• EZH2 is important in the self renewal and proliferation of numerous stem cell types including fetal hematopoietic stem cells, muscle satellite cells, hepatic stem/progenitor cells, neural stem cells, basal cell progenitors in the developing epidermis, embryonic stem cells, and some cancer stem cells.