Gαq Mouse, Unlabeled, Clone: 10, BD

Description

• Description The GTP binding regulatory proteins (G proteins) consist of three subunits: α, β, and γ
• These heterotrimeric proteins function at membranes to relay signals from cell surface receptors to intracellular effectors
• The α subunit is unique for each G protein and contains the site of GTP binding and hydrolysis, as well sites for receptor and effector interactions
• The βγ subunit complex interacts directly with receptors and the α subunit
• The Gα family includes four families: the Gαs family including Gαs , Gαo1f, and Gαt, the Gαi family including Gαi, Gαo, and Gαz, the Gαq/Gα11 family and the Gα12/13 family
• The Gαq protein is 88% homologus with Gα11 and both are widely expressed
• These G proteins activate phospholipase C proteins, which induce calcium signaling events
• G protein coupled receptors (GPCRs) involved in regulating Wnt signaling activate Gαq, phospholipase Cβ, and induce calcium-dependent activation of calpain
• These events promote β-catenin nuclear export and proteolysis
• Gαq has also been implicated in metabotropic glutamate receptor signaling
• Thus, Gαq isoforms activate phospholipase C proteins in various G-protein coupled receptor pathways
• Immunofluorescence, Western Blotting