DSIF Mouse, Unlabeled, Clone: 17, BD

Description

• In living systems, the relative amounts of any protein are controlled at many levels
• For example, amounts are affected by protein degradation, regulation of the translational rates of polypeptide synthesis (translational regulation), and control of the rates of mRNA synthesis (transcriptional regulation)
• Transcriptional regulation involves modulation of the rate-limiting enzyme RNA polymerase
• DSIF (DRB sensitivity-inducing factor) is a heterodimeric transcription elongation protein
• It is composed of a large subunit of 160kDa and a small subunit of 14kDa
• These large and the small subunits are homologs of the yeast gene products Stp5 and Stp4, respectively
• Spt4 and 5 are transcription factors which are critically important for the activity of RNA polymerase
• In conjunction with DRB, DSIF attenuates RNA polymerase II elongation steps
• However, in limiting amounts of ribonucleotides, DSIF, by itself, stimulates the elongation rate of RNA polymerase II
• Thus, the identification of a human regulator for transcriptional elongation will greatly enhance our understanding of this critical step in mammalian gene expression
• Host Species: Mouse Clone: 17 Isotype: IgG1 Species Reactivity: Human Immunogen: Human DSIF aa
• 866-985 Formula Weight [Chemical]: 160kDa Immunofluorescence, Western Blotting