ILK Mouse, Unlabeled, Clone: 3, BD

Description

• Integrins are transmembrane receptors that mediate cell-cell or cell-matrix adhesion
• All integrins are heterodimers composed of α and β subunits, which interact with extracellular matrix and cytoskeletal proteins
• Signal transduction through intergin receptors may be regulated by integrin-linked kinase (ILK)
• ILK is a widely expressed Ser/Thr protein kinase that contains four ankyrin-like repeats in the N-terminal region, a phoshoinositide lipid-binding motif at amino acids 180-212, and an integrin binding site at amino acids 293-451
• The ankyrin repeats interact with a LIM domain-only protein called PINCH that also binds the adaptor protein, Nck-2
• This interaction implicates ILK in growth factor receptor pathways
• In addition, the interaction of ILK with the cytoplasmic domains of integrin β1 and β3 subunits and localization of ILK to focal adhesion plaques suggests a role for ILK in the regulation of cell adhesion
• Interestingly, overexpression of ILK in epithelial cells inhibits cell adhesion and stimulates cell cycle progression and tumorigenicity
• Thus, ILK regulates signal transduction in many different cell signaling pathways
• Host Species: Mouse Clone: 3 Isotype: IgG2 Species Reactivity [for Features Main]: Human Immunogen: Human ILK aa
• 326-452 Immunofluorescence, Western Blotting