CUL-3 Mouse, Unlabeled, Clone: 3, BD

Description

• The cullins are a family of proteins that are integral to cell cycle regulation
• Members of this family include human Cul proteins, C.elegans Ce-Cul-1, and S
• cerevisiae Cdc53
• Proper control of cell cycle progression is essential for the prevention of tumorigenesis
• Mutant forms of both Ce-Cul-1 and Cdc53 have been implicated in the oncogenic process
• The human Cul family of proteins, Cul-1, -2, -3, -4A, -4B, and -5, have also been implicated in oncogenic processes
• Abnormal nuclear localization of Cul-2 is seen in a rare hereditary condition known as VHL (von Hippel-Lindau) syndrome
• Patients with VHL syndrome possess a mutant VHL gene and develop cancers such as retinal anginomas, CNS hemangioblastomas, and renal cell carcinomas
• Cul-3 is widely expressed in normal cells and tissues, and shows increased expression in colon cancer cells
• Cul-3 can associate with cyclin E in mammalian cells, and overexpression of Cul-3 targets cyclin E for ubiquination, while deletion of Cul-3 in mice leads to increased cyclin E accumulation and abnormal regulation of S-phase
• Thus, the Cul family of proteins may have roles in cell cycle regulation and tumoriogenesis
• Host Species: Mouse Clone: 3 Isotype: IgG1 Species Reactivity [for Features Main]: Rat Immunogen: Human CUL-3 aa
• 565-684 Immunofluorescence, Western Blotting