Exportin-1 (CRM1) Mouse anti-Human, Unlabeled, Clone: 17, BD

Description

• The nuclear pore complex (NPC) is a 125MDa nuclear envelope complex that mediates nucleocytoplasmic shuttling of RNA and protein
• NPC is comprised of more than 30 different proteins, including Ran/TC4, importins, and exportins
• Exportin-1(hCRM1/XPO1) is the widely expressed human homologue of the yeast CRM1 protein, which functions in the maintenance of chromatin structure and nuclear export
• Exportin-1 has an N-terminal CRIME domain that is homologous to yeast CRM1 and importin-β
• Intracellular localization of Exportin-1 shows association with the NPC and overexpression of Exportin-1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus
• Exportin-1 also binds other nuclear transport related proteins, such as RanGTP, snurportin-1, and the nucleoporins CAN/Nup214 and Nup50
• Overexpression of CAN leads to sequestration of Exportin-1 in the nucleoplasm, which inhibits cell growth and induces apoptosis
• In addition, Exportin-1 may export specific proteins, such as Rev and PKI, via binding to a leucine-rich nuclear export signal (NES)
• Thus, Exportin-1 is an important protein and RNA nuclear export receptor, which may be required for normal cell growth and survival
• Host Species: Mouse Clone: 17 Isotype: IgG1 Species Reactivity [for Features Main]: Human Immunogen: Human hCRM1 aa
• 2-122 Immunofluorescence, Western Blotting