CD157 Mouse anti-Mouse, Brilliant Violet 421, Clone: BP-3, BD Optibuild™

Description

• The BP-3 antibody reacts with CD157, also known as the BP-3 alloantigen or Bone marrow ST romal cell antigen- 1 (BST-1), found in a variety of common laboratory strains of mice (AKR, BALB/c, CBA/N, C3H/HeJ, C57BL/6, DBA/2, NZB, C.B-17, SJL and Swiss, but not A/J)
• CD157 is a differentially glycosylated GPI-linked cell-surface glycoprotein with a core protein of 32 kDa and differing patterns of glycosylation in different types of cells
• It is a member, along with CD38, of a family of genetically-related ectoenzymes
• The BP-3 alloantigen is expressed on the B lineage from the earliest detectable progenitors to circulating immature B lymphocytes, on immature thymocytes up to the expression of the T-cell receptor, on circulating neutrophils, peritoneal macrophages, on subpopulations of stromal cells in peripheral lymphoid organs (but not in bone marrow or thymus), on intestinal epithelial cells, and in the lumen of kidney-collecting tubules
• The distribution of CD157 antigen on leukocytes and stromal cells of lymphoid organs suggests that it may be involved in leukocyte-stroma interactions which support the development, migration, and/or responses of leukocyte populations.