CD141 Mouse anti-Human, Brilliant Violet 605, Clone: 1A4, BD Optibuild™

Description

• Reacts with a 75 kDa, a single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin
• CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes
• It is also found on megakaryocytes, peripheral blood moncytes, and neutrophils, but not on lymphocytes
• Reports indicate that CD 141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway
• Thrombin loses its procagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C
• This antibody is conjugated to BD Horizon™ BV605 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 407-nm and Em Max of 602-nm, BD Horizon BV605 can be excited by a violet laser and detected with a standard 610/20-nm filter set
• BD Horizon BV605 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an Em max at 605-nm
• Due to the excitation of the acceptor dye by the green (532 nm) and yellow-green (561 nm) lasers, there will be significant spillover into the PE and BD Horizon PE-CF594 detectors off the green or yellow-green lasers
• BD Horizon BV605 conjugates are very bright, often exhibiting brightness equivalent to PE conjugates and can be used as a third color off of the violet laser.