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BDB742668

CD140a Mouse anti-Human, Brilliant Violet 711, Clone: αR1 (also known as Alpha-R1), BD Optibuild™

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB742668-Each-of-1 In Stock ₹ 47,400.24

BDB742668 - Each of 1

₹ 47,400.24

In Stock

Quantity

1

Base Price: ₹ 47,400.24

GST (18%): ₹ 8,532.043

Total Price: ₹ 55,932.283

Antigen

CD140a

Clone

αR1 (also known as Alpha-R1)

Conjugate

Brilliant Violet 711

Gene Alias

PDGF Receptor α, PDGFRA, PDGFRα, PDGF-R-alpha, PDGFR2, PGFRA, RHEPDGFRA

Immunogen

Human PDGFRα Transfected Cell Line

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG2a κ

Description

  • The αR1 monoclonal antibody specifically binds to the human platelet derived growth factor (PDGF) receptor α (PDGFRα), also known as CD140a
  • CD140a is a 170 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes
  • PDGF receptors α and βare single glycoproteins with intracellular tyrosine kinase domains
  • They are structurally similar to the M-CSF receptor and CD117 (c-kit)
  • Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells
  • PDGF plays a role in wound healing and it also acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils
  • Functional PDGF is secreted in disulfide linked, homodimeric or heterodimeric forms comprised of A or B chains (PDGFAA, PDGF-BB or PDGF-AB)
  • Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ
  • The PDGFRαsubunit binds both PDGF A and B chains, whereas the PDGFRβ subunit binds only PDGF B chains
  • Although both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis.TheαR1antibody is specific for PDGFRαand does not crossreact with PDGFRβ
  • It immunoprecipitates human, monkey, rabbit, pig, dog and cat PDGFRα
  • It does not recognize hamster, rat or mouse PDGFRα
  • The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes
  • This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 711nm
  • BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20nm filter)
  • Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
  • However, the spillover can be corrected through compensation as with any other dye combination
  • BV711 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 711 nm
  • This dye offers a very bright choice for the violet laser
  • Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
  • BV711 will also have moderate spillover into the BD Horizon Brilliant™ Violet 786 detector.

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Show Difference

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BD Biosciences

BDB742668

--

Antigen:
CD140a
Clone:
αR1 (also known as Alpha-R1)
Conjugate:
Brilliant Violet 711
Gene Alias:
PDGF Receptor α, PDGFRA, PDGFRα, PDGF-R-alpha, PDGFR2, PGFRA, RHEPDGFRA
Immunogen:
Human PDGFRα Transfected Cell Line
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ

Img

BD Biosciences

BDB742670

--

Antigen:
CD140a
Clone:
αR1 (also known as Alpha-R1)
Conjugate:
Brilliant Ultraviolet 395
Gene Alias:
PDGF Receptor α, PDGFRA, PDGFRα, PDGF-R-alpha, PDGFR2, PGFRA, RHEPDGFRA
Immunogen:
Human PDGFRα Transfected Cell Line
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ

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BD Biosciences

BDB742674

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Antigen:
CD238
Clone:
BRIC 203
Conjugate:
Brilliant Violet 711
Gene Alias:
KEL, KELL, Kell blood group, metallo-endopeptidase, ECE3
Immunogen:
Human erythrocytes
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ

Img

BD Biosciences

BDB742675

--

Antigen:
CD238
Clone:
BRIC 203
Conjugate:
Brilliant Violet 786
Gene Alias:
KEL, KELL, Kell blood group, metallo-endopeptidase, ECE3
Immunogen:
Human erythrocytes
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ