BDB743384
CD117 Rat anti-Mouse, Brilliant Violet 510, Clone: 2B8, BD Optibuild™
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB743384-Each-of-1 | In Stock | ₹ 34,224.00 |
BDB743384 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,224.00
GST (18%): ₹ 6,160.32
Total Price: ₹ 40,384.32
Antigen
CD117
Clone
2B8
Conjugate
Brilliant Violet 510
Gene Alias
c-KIT, W, SCFR, Stem Cell Factor Receptor, Sl, Steel Factor Receptor, Ssm
Immunogen
Mouse Bone Marrow Mast Cells
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2b κ
Related Products
Description
- 2B8 monoclonal antibody specifically binds to CD117 (c-Kit), a transmembrane tyrosine-kinase receptor that is encoded by the Kit/gene (formerly dominant white spotting, W/)
- The c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor) encoded by the Kit1 gene (formerly steel, SI), is a co-mitogen for hematopoietic stem cells, myeloerythroid progenitors and a mast-cell differentiation factor
- The KitW and Kit1SI mutant alleles have similar pleiotropic effects on the development of melanocytes, germ cells, and the hematopoietic system
- In adult bone marrow, CD117 is expressed on hematopoietic progenitor cells, including CD90 (Thy-1) low, TER-119-, CD45R/B220-, CD11b (Mac-1)-, Ly-6G (Gr-1)-, CD4-, CD8-, and Sca-1 (Ly-6A/E)+ multipotent hemotopoietic stem cells, progenitors committed to myeliod and/or erythroid lineages, and precursors of B and T lymphocytes
- This widespread expression of CD117 in hematopoietic precursors is consistent with the participation of c-Kit and its ligand in the regulation of several hematopoietic lineages
- Intrathymic expression of c-Kit and c-Kit ligand suggest that CD117 is also involved in the regulation of some events during the development of T lymphocytes
- CD117 is also expressed by mast cells and by dendritic cells found in the periarteriolar lymphocytoc sheaths (T-cell areas) of splenic white pulp
- The mAb 2B8 reportedly does not block the action of c-Kit
- This clone 2B8 had been reported to cross-react with rat
- The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
- With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set
- BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser
- BV510 is a polymer-based dye that is brighter than BD Horizon V500
- Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
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Antigen: CD117
Clone: 2B8
Conjugate: Brilliant Violet 510
Gene Alias: c-KIT, W, SCFR, Stem Cell Factor Receptor, Sl, Steel Factor Receptor, Ssm
Immunogen: Mouse Bone Marrow Mast Cells
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2b κ
Antigen:
CD117
Clone:
2B8
Conjugate:
Brilliant Violet 510
Gene Alias:
c-KIT, W, SCFR, Stem Cell Factor Receptor, Sl, Steel Factor Receptor, Ssm
Immunogen:
Mouse Bone Marrow Mast Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2b κ
Antigen: CD266
Clone: ITEM-1
Conjugate: Brilliant Violet 510
Gene Alias: TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14
Immunogen: Human
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
CD266
Clone:
ITEM-1
Conjugate:
Brilliant Violet 510
Gene Alias:
TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14
Immunogen:
Human
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Antigen: CD266
Clone: ITEM-1
Conjugate: Brilliant Violet 605
Gene Alias: TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14
Immunogen: Human
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
CD266
Clone:
ITEM-1
Conjugate:
Brilliant Violet 605
Gene Alias:
TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14
Immunogen:
Human
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Antigen: CD266
Clone: ITEM-1
Conjugate: Brilliant Violet 650
Gene Alias: TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14
Immunogen: Human
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
CD266
Clone:
ITEM-1
Conjugate:
Brilliant Violet 650
Gene Alias:
TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14
Immunogen:
Human
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ