Dta-Like Ptein 4 Mouse, anti-Mouse, R718, Clone: 9A1.5, BD OptiBuild™

Description

• The 9A1.5 monoclonal antibody specifically binds to an extracellular domain of Delta-Like Protein 4 that is encoded by the Dll4 gene
• Delta-Like Protein 4 is a type 1 transmembrane glycoprotein that is also known as Delta-like 4, Delta-like Ligand 4, Delta4 and DL4
• It is a member of the Delta/Serrate/Jagged Family of Notch ligands
• Notch ligands are classified by the presence of specific structural motifs including an N-terminal Delta-Serrate-LAG-2 (DSL) domain necessary for Notch binding, EGF repeats, and the DOS domain (a specialized EGF repeat)
• The Notch family of transmembrane receptors and their ligands control cell-fate decisions during the development of many organs in a wide variety of animal species
• Delta-Like Protein 4 activates cellular signaling pathways by binding to Notch1 and Notch4 receptors
• It is involved in embryonic vascular development and tumor angiogenesis, and is induced by vascular endothelial growth factor (VEGF)-A and hypoxia
• Delta-Like Protein 4 and Notch receptor signaling are also intimately involved in the regulation of innate and adaptive immunity
• Delta-Like Protein 4 is highly expressed by cortical thymic epithelial cells (TEC)
• Interaction between Delta-Like Protein 4-positive TEC and Notch1 expressed by T cell precursors drives T cell lineage commitment, expansion and maturation within the thymus
• Delta-Like Protein 4 is also expressed by dendritic cells and plays a role in peripheral T helper cell differentiation
• Blocking of Delta-Like Protein 4 and Notch receptor interactions serves to diminish autoimmune diseases in mouse model systems.