CD365 (TIM-1) Mouse, anti-Human, R718, Clone: 1D12, BD OptiBuild™

Description

• The 1D12 monoclonal antibody specifically binds to CD365, the T-cell immunoglobulin mucin receptor 1 (TIM-1)
• TIM-1 is expressed on kidney epithelial cells, T cells, and some hematopoietic and non-hematopoietic cells
• CD365 (TIM-1) is a type 1 transmembrane glycoprotein that serves as a receptor for hepatitis A virus and is encoded by the HAVCR1 (Hepatitis A virus cellular receptor 1) gene
• TIM-1 also serves as a receptor for phosphatidylserine which is exposed on the surface of apoptotic cells
• TIM-1 can reportedly mediate the uptake of apoptotic cells through the recognition of phosphatidylserine and thus help maintain tissue homeostasis and self-tolerance
• TIM-1 is likewise known as Kidney injury molecule 1 (KIM-1)
• It is highly expressed by cancerous kidneys, and upregulated in the proximal tubular epithelium and shed into the urine during acute and chronic kidney injury
• CD365 (TIM-1) also functions as a costimulatory molecule for immune cells
• It is expressed by activated CD4+ T cells and regulates the effector functions (eg, enhanced cytokine production) and survival of differentiated T cells, including those mediating Th2-like immune responses
• Other ligands have been described for TIM-1 including TIM-4 and LMIR5 (also known as CD300b) which are expressed by myeloid cells
• With respect to disease associations, the HAVCR1 gene has been linked to asthma, allergy, and some autoimmune diseases.