SIRP Gma (CD172g) Mouse, anti-Human, R718, Clone: OX-119, BD OptiBuild™

Description

• Description The OX-119 monoclonal antibody specifically recognizes Signal-regulatory protein gamma (SIRP-gamma or SIRPγ) which is also known as CD172g or Signal-regulatory protein beta 2 (SIRP-beta-2 or SIRPβ2)
• SIRPγ (CD172g) is a ∼55 kDa type I transmembrane glycoprotein that is encoded by SIRPG, which belongs to the SIRPβ2 subfamily within the Ig gene superfamily
• The SIRPγ (CD172g) extracellular domain contains one amino-terminal IgV-like domain and two IgC-like domains, and a short cytoplasmic region with no known motifs
• It is expressed on mature thymocytes, CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, all activated NK cells and some B cells
• SIRPγ (CD172g) binds to CD47 (integrin-associated protein/IAP) that is widely expressed on most hematopoietic cells, epithelial cells, endothelial cells, fibroblasts and many tumor cell lines
• SIRPγ (CD172g) may play a regulatory role in T cell-T cell interactions and may induce apoptosis through CD47.