CD195 Mouse, anti-Human, R718, Clone: 3A9, BD OptiBuild™

Description

• The 3A9 monoclonal antibody recognizes CD195, which is also known as the chemokine receptor, CCR5, a seven transmembrane-spanning G protein-associated molecule
• The 3A9 antibody also reportedly cross-reacts with human CCR8
• Results of epitope mapping and sequence comparison between CCR5 and CCR8 reveals that the first three amino acid residues for these two receptors are identical: MDY (Met-Asp-Tyr)
• CCR5 belongs to the β-chemokine receptor family
• It is expressed on subsets of T lymphocytes, NK cells, monocytes, macrophages, and dendritic cells
• CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation
• It signals a response to at least three chemokines: RANTES and macrophage inflammatory protein-1 (MIP-1) α and β
• Additionally, CCR5 has been found to be a co-receptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission
• Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection
• CCR5 has been clustered as CD195 in the VIIth HLDA workshop.