CD93 Mouse, anti-Human, R718, Clone: R139, BD OptiBuild™

Description

• The R139 monoclonal antibody specifically binds to CD93 which is also known as Complement component C1q receptor (C1qR), C1q receptor 1 (C1qR1), or Matrix-remodeling-associated protein 4 (MXRA4)
• The immunogen used to generate the R139 hybridoma was a preparation of CD93 protein
• Human CD93 is a transmembrane glycoprotein that is highly expressed on monocytes, macrophages, granulocytes, and endothelial cells but not on T and B lymphocytes
• CD93 is also known as the C1q/MBL/SPA Receptor as it binds C1q, the recognition subunit of the first component (C1) of the complement pathway, as well as MBL (Mannose-binding-lectin) and SPA (Pulmonary Surfactant Protein A)
• Human C1qRp is involved in the C1q-mediated enhancement of phagocytosis
• R139 is suitable to detect CD93 expression on cells of myeloid lineage by flow cytometry, and CD93 in cellular lysates by Western blotting or immunoprecipitation
• In addition, R139 reportedly neutralizes C1q-mediated enhancement of phagocytosis
• CD93 has also been reported to define a human stem cell population with hematopoietic and hepatic potential.