CD13 Mouse, anti-Human, R718, Clone: L138, BD OptiBuild™

Description

• The L138 monoclonal antibody (also known as Leu-M7) specifically binds to a glycosylated 150 kDa type II integral membrane zinc-metalloprotease
• The CD13 antigen is also known as aminopeptidase N, APN, ANPEP, and gp150
• The CD13 antigen is expressed on granulocytes, monocytes, mast cells, and granulocyte/macrophage progenitor cells (CFU-GM), but not on lymphocytes, platelets, or erythrocytes
• It is expressed on most acute myeloid leukemia (AML) cells and some chronic myeloid leukemia (CML) cells
• The CD13 antigen is also expressed on epithelial cells of the kidney, small intestine, and respiratory tract, as well as in synaptic membranes in the central nervous system (CNS)
• The CD13 antigen is involved in the metabolism of many regulatory peptides
• Clustering of the CD13 antigen by various forms of ligation promotes the adhesion between monocytes and endothelial cells
• The CD13 antigen is the receptor for human coronavirus 229E, the causative agent for some cases of upper respiratory infection.