CD18 Mouse, anti-Rat, R718, Clone: WT.3, BD OptiBuild™

Description

• The WT.3 monoclonal antibody specifically recognizes the 95-100 kDa β2 subunit (CD18), which is found on the majority of leukocytes as a heterodimer with any of the three distinct CD11 α integrin subunits (CD11a or αL, CD11b or αM, CD11c or αX) to form, respectively, LFA-1, Mac-1, and gp150, 95
• The function-blocking activity of WT.3 antibody has been determined in several in vitro assays measuring the binding of LFA-1 (αLβ2 integrin) to ICAM-1 (CD54)
• It has also been reported that WT.3 mAb inhibits leukocyte infiltration in an in vivo system.