CD249 Mouse, anti-Human, R718, Clone: 2D3/APA, BD OptiBuild™

Description

• The 2D3 monoclonal antibody specifically binds to CD249
• CD249 is encoded by ENPEP and is also known as Aminopeptidase A (APA/AP-A), Glutamyl aminopeptidase (EAP), and gp160
• CD249 is expressed by epithelial and endothelial cells in a variety of tissues including those that comprise the proximal tubules and glomeruli of the kidneys
• It is also expressed by early B-lineage cells and cell lines
• CD249 belongs to the peptidase M1 family and catalyzes the release of N-terminal glutamate (and to a lesser degree, aspartate) from peptides
• This ectoenzyme catalyzes the conversion of angiotensin II to angiotensin III which is important in the local regulation of blood pressure
• It may also play roles in the regulation of angiogenesis and development of B cells.