DR104150UL
MilliporeSigma™ anti-TIP60, Polyclonal
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | DR104150UL-Each-of-1 | In Stock | ₹ 25,021.17 |
DR104150UL - Each of 1
In Stock
Quantity
1
Base Price: ₹ 25,021.17
GST (18%): ₹ 4,503.811
Total Price: ₹ 29,524.981
Antigen
TIP60
Classification
Polyclonal
Formulation
Undiluted serum.
Immunogen
recombinant, human TIP60 protein
Regulatory Status
RUO
Test Specificity
Recognizes the ∽60kDa TIP60 protein in Saos-2 cells.
Content And Storage
−20°C
Isotype
IgG
Applications
Immunoprecipitation
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
50 μL
Primary or Secondary
Primary
Target Species
Human
Form
Undiluted
Related Products
Description
- Specifically detects TIP60 Clone: in Human samples, and it is validated for Immunoprecipitation TIP60 (accession no
- Q92993) is a 60kDa protein that is a member of the MYST family, which is a distinct class of histone acetyl-transferases (HAT)
- TIP60 was initially identified as a protein that interacts with the HIV protein, Tat, and shares no homology with the HATs, CBP/p300, or PCAF
- TIP60 was recently shown to modulate DNA repair and p53 function
- TIP60 also directly acetylatesγ-H2AX and, together with the cofactor, TRRAP, binds to the chromatin surrounding sites of DNA double-stranded breaks in vivo
- Furthermore, TIP60 associates with MYC and recruits it to the chromatin, which results in MYC-induced actetylation of histone H4
- TIP60 directly associates with p53 and specifically acetylates it at K 120 , modulating the decision between cell cycle arrest and apoptosis
- TIP60 acts as a transcription coactivator of p53 that enhances the activation of p21 and puma, leading to cell growth arrest and apoptosis
- K 120 actetylation is essential for p53-mediated puma activation and apoptosis, but is dispensable for both p53-mediated growth arrest, through p21 activation, and p53/MDM2 interaction
- K 120 is not acetylated by p300 and its actetylation by TIP60 does not affect the stability or DNA binding activity of p53.
Compare Similar Items
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Antigen: TIP60
Classification: Polyclonal
Formulation: Undiluted serum.
Immunogen: recombinant, human TIP60 protein
Regulatory Status: RUO
Test Specificity: Recognizes the ∽60kDa TIP60 protein in Saos-2 cells.
Content And Storage: −20°C
Isotype: IgG
Applications: Immunoprecipitation
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human
Form: Undiluted
Antigen:
TIP60
Classification:
Polyclonal
Formulation:
Undiluted serum.
Immunogen:
recombinant, human TIP60 protein
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽60kDa TIP60 protein in Saos-2 cells.
Content And Storage:
−20°C
Isotype:
IgG
Applications:
Immunoprecipitation
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Undiluted
Antigen: GCLC
Classification: Monoclonal
Formulation: In PBS, pH 7.2.
Immunogen: A recombinant polypeptide corresponding to amino acids 528-638 of human GCLC, expressed as a GST fusion protein
Regulatory Status: RUO
Test Specificity: Recognizes the ∽70kDa GCLC protein in HeLa and A431 cells.
Content And Storage: −20°C
Isotype: IgG1
Applications: ELISA, Immunoblot, Immunoblot, Immunocytochemistry
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
GCLC
Classification:
Monoclonal
Formulation:
In PBS, pH 7.2.
Immunogen:
A recombinant polypeptide corresponding to amino acids 528-638 of human GCLC, expressed as a GST fusion protein
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽70kDa GCLC protein in HeLa and A431 cells.
Content And Storage:
−20°C
Isotype:
IgG1
Applications:
ELISA, Immunoblot, Immunoblot, Immunocytochemistry
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: SALL4
Classification: Monoclonal
Formulation: In PBS, pH 7.2.
Immunogen: A recombinant polypeptide corresponding to amino acids 954-1054 of human SALL4, expressed as a GST fusion protein
Regulatory Status: RUO
Test Specificity: Recognizes the ∽100kDa SALL4 protein in HeLa and NIH3T3 cells and human testes tissue.
Content And Storage: −20°C
Isotype: IgG1
Applications: ELISA, Immunoblot, Immunoblot, Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
SALL4
Classification:
Monoclonal
Formulation:
In PBS, pH 7.2.
Immunogen:
A recombinant polypeptide corresponding to amino acids 954-1054 of human SALL4, expressed as a GST fusion protein
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽100kDa SALL4 protein in HeLa and NIH3T3 cells and human testes tissue.
Content And Storage:
−20°C
Isotype:
IgG1
Applications:
ELISA, Immunoblot, Immunoblot, Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Antigen: SQSTM1
Classification: Polyclonal
Formulation: In PBS, pH 7.2.
Immunogen: Full-length human SQSTM1 (aa 1-440)
Regulatory Status: RUO
Test Specificity: Recognizes the ∽60kDa SQSTM1 protein in HeLa cells.
Content And Storage: −20°C
Isotype: IgG1
Applications: Immunocytochemistry
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 50 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
SQSTM1
Classification:
Polyclonal
Formulation:
In PBS, pH 7.2.
Immunogen:
Full-length human SQSTM1 (aa 1-440)
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽60kDa SQSTM1 protein in HeLa cells.
Content And Storage:
−20°C
Isotype:
IgG1
Applications:
Immunocytochemistry
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
50 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified