FEMA550109

tPA Recombinant Rabbit Monoclonal Antibody (32B1), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 FEMA550109-Each-of-1 In Stock ₹ 35,764.08

FEMA550109 - Each of 1

₹ 35,764.08

In Stock

Quantity

1

Base Price: ₹ 35,764.08

GST (18%): ₹ 6,437.534

Total Price: ₹ 42,201.614

Antigen

tPA

Classification

Recombinant Monoclonal

Concentration

3 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.

P00750

Gene Symbols

PLAT

Immunogen

A synthesized peptide derived from Human PLAT

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Form

Liquid

Applications

ELISA, Flow Cytometry

Clone

32B1

Conjugate

Unconjugated

Gene

PLAT

Gene Alias

3.4.21.68, Alteplase, AU020998, AW212668, D8Ertd2e, PATISS, plasminogen activator, tissue, plasminogen activator, tissue type, plasminogen/activator kringle, PLAT, Reteplase, serine protease, t plasminogen activator, tissue plasminogen activator, tissue-type plasminogen activator, Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B, TPA, t-PA, t-plasminogen activator

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

5327

Content And Storage

-20°C or -80°C if preferred

Isotype

IgG

Related Products

Img

Thermo Scientific

FEMA549935

--

Img

Thermo Scientific

FEMA550263

--

Img

Thermo Scientific

FEMA550589

--

Img

Thermo Scientific

FEMA550167

--

Img

Thermo Scientific

FEMA550032

--

Img

Thermo Scientific

FEMA550054

--

Img

Thermo Scientific

FEMA550030

--

Img

Thermo Scientific

FEMA550046

--

Description

  • TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen
  • By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physio pathological events
  • It specifically cleaves the Arg- -Val bond in plasminogen to form plasmin, and is comprised of a heterodimer of chain A and chain B held by a disulfide bond
  • TPA binds to fibrin with high affinity
  • This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-and 1000-fold, due to an increase in affinity for plasminogen
  • Similarly, binding to heparin increases the activation of plasminogen
  • Binding to laminin and fibronectin has also been demonstrated
  • TPA also binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1)
  • These proteins are involved in TPA clearance
  • TPA binds to annexin II and to cytokeratin 8
  • As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation
  • In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.

Compare Similar Items

Show Difference

Img

Thermo Scientific

FEMA550109

--


Antigen:
tPA

Classification:
Recombinant Monoclonal

Concentration:
3 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
P00750

Gene Symbols:
PLAT

Immunogen:
A synthesized peptide derived from Human PLAT

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Flow Cytometry

Clone:
32B1

Conjugate:
Unconjugated

Gene:
PLAT

Gene Alias:
3.4.21.68, Alteplase, AU020998, AW212668, D8Ertd2e, PATISS, plasminogen activator, tissue, plasminogen activator, tissue type, plasminogen/activator kringle, PLAT, Reteplase, serine protease, t plasminogen activator, tissue plasminogen activator, tissue-type plasminogen activator, Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B, TPA, t-PA, t-plasminogen activator

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
5327

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG

Img

Thermo Scientific

FEMA550111

--


Antigen:
IL-8 (CXCL8)

Classification:
Recombinant Monoclonal

Concentration:
1.5 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
P10145

Gene Symbols:
CXCL8

Immunogen:
A synthesized peptide derived from Human IL8

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Flow Cytometry

Clone:
33A9

Conjugate:
Unconjugated

Gene:
CXCL8

Gene Alias:
(Ala-IL-8)77, (Ser-IL-8)72, Alveolar macrophage chemotactic factor I, alveolar macrophage-derived chemotactic factor-I, AMCF-I, ANX7, beta endothelial cell-derived neutrophil activating peptide, beta-thromboglobulin-like protein, chemokine (C-X-C motif) ligand 8, C-X-C motif chemokine 8, C-X-C motif chemokine ligand 8, CXCL8, cytokine 8, emoctakin, GCP/IL-8 protein I, GCP/IL-8 protein II, GCP/IL-8 protein III, GCP/IL-8 protein IV, GCP/IL-8 protein V, GCP/IL-8 protein VI, GCP1, GCP-1, Granulocyte chemotactic protein 1, IL8, IL-8, IL-8(1-77), IL-8(5-77), IL-8(6-77), IL-8(7-77), IL-8(8-77), IL-8(9-77), IL8/NAP1 form I, IL8/NAP1 form II, IL8/NAP1 form III, IL8/NAP1 form IV, IL8/NAP1 form V, IL8/NAP1 form VI, ILN, Interleukin, interleukin 8, Interleukin8, interleukin-8, interleuklin-8 precursor, LECT, LUCT, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, Lymphocyte-derived neutrophil-activating factor, LYNAP, MDNCF, MDNCF-a, MDNCF-b, MDNCF-c, MONAP, Monocyte-derived neutrophil chemotactic factor, monocyte-derived neutrophil-activating peptide, NAF, NAP1, NAP-1, neutrophil activating peptide 1, neutrophil and T-lymphocyte chemotactic and activating factor, Neutrophil attractant/activation protein 1, neutrophil attractant/activation protein-1, Neutrophil-activating factor, neutrophil-activating peptide 1, Neutrophil-activating protein 1, Permeability factor 1, PF1, Protein 3-10C, RP11-537A6.8, RPF1, small inducible cytokine subfamily B, member 8, SNX, SYNEXIN, T-cell chemotactic factor, tumor necrosis factor-induced gene 1

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3576

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG

Img

Thermo Scientific

FEMA550114

--


Antigen:
GAA

Classification:
Recombinant Monoclonal

Concentration:
0.8 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
P10253

Gene Symbols:
Gaa

Immunogen:
A synthesized peptide derived from Human GAA

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Immunohistochemistry (Paraffin)

Clone:
5E5

Conjugate:
Unconjugated

Gene:
Gaa

Gene Alias:
70 kDa lysosomal alpha-glucosidase, 76 kDa lysosomal alpha-glucosidase, acid (Pompe disease, glycogen storage disease type II), acid alpha-glucosidase, acid maltase, Aglucosidase alfa, E430018M07Rik, Gaa, glucosidase alpha, acid, glucosidase, alpha, acid, glucosidase, alpha, acid (Pompe disease, glycogen storage disease type II), LYAG, Lysosomal alpha-glucosidase

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
2548

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG

Img

Thermo Scientific

FEMA550115

--


Antigen:
L-Plastin

Classification:
Recombinant Monoclonal

Concentration:
0.2 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
P13796

Gene Symbols:
LCP1

Immunogen:
A synthesized peptide derived from Human LCP1

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Flow Cytometry

Clone:
29G10

Conjugate:
Unconjugated

Gene:
LCP1

Gene Alias:
65 kDa macrophage protein, AW536232, bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)), cb245, CP64, D14Ertd310e, DKFZp781A23186, epididymis secretory protein Li 37, fj24b12, FLJ25423, FLJ26114, FLJ39956, HEL-S-37, LC64P, LCP1, LCP-1, leucocyte-specific plastin 1, L-fimbrin, LPL, L-plastin, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65), L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P), lymphocyte cytosolic plastin 1, lymphocyte cytosolic protein 1, lymphocyte cytosolic protein 1 (L-plastin), Lymphocyte cytosolic protein-1 (plasmin), plastin 2, plastin 2, L, plastin-2, Pls2, pp65, wu:fj24b12

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3936

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG