IM29L100UG
MilliporeSigma™ anti-PAI-1 Clone: 2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | IM29L100UG-Each-of-1 | In Stock | ₹ 44,891.60 |
IM29L100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,891.60
GST (18%): ₹ 8,080.488
Total Price: ₹ 52,972.088
Antigen
PAI-1
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Immunoprecipitation, Neutralization
Clone
2
Formulation
Lyophilized from a volatile buffer, 100μg BSA.
Immunogen
partially purified PAI-1 from conditioned medium of dexamethasone-treated HT1080 human cells
Regulatory Status
RUO
Test Specificity
Recognizes both active and latent forms of the ∽50kDa PAI-1 protein in conditioned media from dexamethasone-treated HT-1080 cells. Sold under license of U.S. Patent 5,422,245.
Content And Storage
2°C to 8°C
Isotype
IgG1
Related Products
Description
- Specifically detects PAI-1 Clone: 2 in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Neutralization Plasminogen activator inhibitor 1 (PAI-1) is a secreted glycoprotein of approximately 50kDa, which functions as the primary regulator of uPA and tPA activity
- PAI-1 and the related inhibitor, PAI-2, are members of the serine proteinase inhibitor (serpin) gene superfamily
- PAI-1 is produced by a variety of cell types and is present in normal human plasma
- It exists as two conformationally distinct forms, latent and active
- The active form binds to uPA in a 1:1 complex resulting in the inhibition of proteolytic activity
- Active PAI-1 rapidly converts to the latent form but can be stabilized in the active conformation by binding to the cell adhesion glycoprotein, vitronectin
- Latent PAI-1 can be activated in vitro by exposure to denaturants such as SDS or guanidine
- PAI-1 levels are increased in a number of disease states including coronary artery disease, venous thrombosis, obesity and various types of cancer
- Recent studies indicate that elevated PAI-1 may be a useful prognostic marker for several types of cancers, particularly breast and lung.
Compare Similar Items
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Antigen: PAI-1
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Neutralization
Clone: 2
Formulation: Lyophilized from a volatile buffer, 100μg BSA.
Immunogen: partially purified PAI-1 from conditioned medium of dexamethasone-treated HT1080 human cells
Regulatory Status: RUO
Test Specificity: Recognizes both active and latent forms of the ∽50kDa PAI-1 protein in conditioned media from dexamethasone-treated HT-1080 cells. Sold under license of U.S. Patent 5,422,245.
Content And Storage: 2°C to 8°C
Isotype: IgG1
Antigen:
PAI-1
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Neutralization
Clone:
2
Formulation:
Lyophilized from a volatile buffer, 100μg BSA.
Immunogen:
partially purified PAI-1 from conditioned medium of dexamethasone-treated HT1080 human cells
Regulatory Status:
RUO
Test Specificity:
Recognizes both active and latent forms of the ∽50kDa PAI-1 protein in conditioned media from dexamethasone-treated HT-1080 cells. Sold under license of U.S. Patent 5,422,245.
Content And Storage:
2°C to 8°C
Isotype:
IgG1
Antigen: MMP-2
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Bovine, Human, Mouse, Rat
Form: Purified
Applications: Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone: 42-5D11
Formulation: In 100mM sodium phosphate buffer, 0.1% BSA, pH 7.0
Immunogen: a synthetic peptide (VTPRDKPMGPLLVATF) corresponding to amino acids 468-483 of human MMP-2
Regulatory Status: RUO
Test Specificity: Recognizes the ∽72kDa latent and the ∽66kDa active forms of the MMP-2.
Content And Storage: −20°C
Isotype: IgG1
Antigen:
MMP-2
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Bovine, Human, Mouse, Rat
Form:
Purified
Applications:
Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone:
42-5D11
Formulation:
In 100mM sodium phosphate buffer, 0.1% BSA, pH 7.0
Immunogen:
a synthetic peptide (VTPRDKPMGPLLVATF) corresponding to amino acids 468-483 of human MMP-2
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽72kDa latent and the ∽66kDa active forms of the MMP-2.
Content And Storage:
−20°C
Isotype:
IgG1
Antigen: MMP-1
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Clone: 41-1E5
Formulation: In 100mM sodium phosphate buffer, 0.1% BSA, pH 7.0, ≤0.1% Sodium Azide.
Immunogen: a synthetic peptide (VQGQNVLHGYPKDIYSSFG) corresponding to amino acids 332-350 of human MMP-1
Regulatory Status: RUO
Test Specificity: __
Content And Storage: -20°C
Isotype: IgG
Antigen:
MMP-1
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Clone:
41-1E5
Formulation:
In 100mM sodium phosphate buffer, 0.1% BSA, pH 7.0, ≤0.1% Sodium Azide.
Immunogen:
a synthetic peptide (VQGQNVLHGYPKDIYSSFG) corresponding to amino acids 332-350 of human MMP-1
Regulatory Status:
RUO
Test Specificity:
__
Content And Storage:
-20°C
Isotype:
IgG
Antigen: MT1-MMP
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone: 114-6G6
Formulation: In 100mM sodium phosphate buffer, 0.1% BSA, pH 7.0.
Immunogen: a synthetic peptide (REVPYAYIREGHEK) corresponding to amino acids 160-173 in the catalytic domain of human MT1-MMP
Regulatory Status: RUO
Test Specificity: Recognizes the ∽60-66kDa MTI-MMP protein in HT-1080 cells and ConA-treated MD-MB-231 cells.
Content And Storage: −20°C
Isotype: IgG1
Antigen:
MT1-MMP
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone:
114-6G6
Formulation:
In 100mM sodium phosphate buffer, 0.1% BSA, pH 7.0.
Immunogen:
a synthetic peptide (REVPYAYIREGHEK) corresponding to amino acids 160-173 in the catalytic domain of human MT1-MMP
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽60-66kDa MTI-MMP protein in HT-1080 cells and ConA-treated MD-MB-231 cells.
Content And Storage:
−20°C
Isotype:
IgG1