MA124750

Cyclin D1 Monoclonal Antibody (DCS-6), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 MA124750-Each-of-1 In Stock ₹ 46,587.42

MA124750 - Each of 1

₹ 46,587.42

In Stock

Quantity

1

Base Price: ₹ 46,587.42

GST (18%): ₹ 8,385.736

Total Price: ₹ 54,973.156

Antigen

Cyclin D1

Classification

Monoclonal

Concentration

2.4 mg/mL

Formulation

Ascites with 15mM sodium azide

Gene Accession No.

P24385, P25322, P39948

Gene Symbols

CCND1

Immunogen

Recombinant, full length human protein.

Regulatory Status

RUO

Gene ID (Entrez)

12443, 58919, 595

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone

DCS-6

Conjugate

Unconjugated

Gene

CCND1

Gene Alias

AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31

Host Species

Mouse

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Non-human Primate, Rat

Product Type

Antibody

Isotype

IgG2a

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Description

  • This antibody does not cross-react with other D-type cyclins
  • Store product as a concentrated solution
  • Centrifuge briefly prior to opening the vial
  • Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein
  • Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL)
  • In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation
  • In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11
  • Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation
  • D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1
  • Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation
  • Cyclin D1 destabilization participates in G1/S phase arrest
  • The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle
  • Cyclins function as regulators of CDK kinases
  • Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event
  • Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition
  • The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb
  • Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis
  • Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.

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Thermo Scientific

MA124750

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Antigen:
Cyclin D1

Classification:
Monoclonal

Concentration:
2.4 mg/mL

Formulation:
Ascites with 15mM sodium azide

Gene Accession No.:
P24385, P25322, P39948

Gene Symbols:
CCND1

Immunogen:
Recombinant, full length human protein.

Regulatory Status:
RUO

Gene ID (Entrez):
12443, 58919, 595

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
DCS-6

Conjugate:
Unconjugated

Gene:
CCND1

Gene Alias:
AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31

Host Species:
Mouse

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Non-human Primate, Rat

Product Type:
Antibody

Isotype:
IgG2a

Img

Thermo Scientific

MA124907

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Antigen:
Actin

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
0.01M PBS with 1% BSA and 15mM sodium azide; pH 7.4

Gene Accession No.:
O18840, P08023, P29751, P48975, P60706, P60709, P60710, P60711, P60712, P60713, P62736, P62737, P62738, P62739, P62740, P63258, P63259, P63260, P63261, P63267, P63268, P63269, P63270, P68032, P68033, P68034, P68035, P68133, P68134, P68135, P68136, P68137, P68138, P68139, Q3ZC07, Q5E9B5, Q5ZMQ2, Q6QAQ1, Q71FK5

Gene Symbols:
Acta1, ACTA2, ACTB, ACTC1, ACTG1, ACTG2

Immunogen:
Synthetic peptide: SGPSIVHRKCF (human) attached to a Multiple Antigen Peptide (MAP) backbone

Regulatory Status:
RUO

Gene ID (Entrez):
100009271, 100009272, 100009506, 100135470, 100152267, 100154254, 100340339, 100350318, 100520667, 100689477, 100716255, 100716933, 100722917, 100731713, 100731953, 100758575, 100764022, 100766388, 100768744, 100768972, 100860883, 101107662, 101111554, 101114256, 101121051, 101844587, 102170606, 102178279, 102179831, 102182476, 102191486, 11459, 11461, 11464, 11465, 11468, 11475, 25365, 280979, 281592, 281595, 287876, 29275, 29437, 396084, 396526, 397653, 403580, 404122, 414396, 415296, 421534, 423298, 423787, 443052, 443340, 475792, 475923, 477587, 478250, 488984, 515610, 533219, 58, 59, 60, 70, 71, 72, 733615, 81633, 81822

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

Applications:
Immunocytochemistry, Western Blot

Clone:
AC-40

Conjugate:
Cyanine3

Gene:
ACTG1

Gene Alias:
0610041G09Rik; 5C actin; A; A4V404_DROME; AA959943; a-actin; AAT6; Ac5C; act; act 5C; ACT1_DROME; Act4; ACT-4; Act5; ACT-5; Act5c; Act-5C; Act5C-PA; Act5C-PB; Act5C-PC; Act5C-PD; Act5C-PE; acta; ACTA1; ACTA1 protein; acta1.S; acta2; Acta-2; ACTA3; ACTB; actb.L; ACTC; ACTC1; Actc-1; ACTE; Actg; ACTG1; Actg2; ACTGE; Actin; actin 5 C; actin 5c; actin A1; actin alpha 1; actin alpha 1, skeletal muscle; actin alpha 2, smooth muscle; actin alpha cardiac; actin alpha cardiac 1; actin alpha cardiac muscle 1; actin beta; actin gamma 1; actin gamma 2, smooth muscle; actin homolog; actin, alpha 1, skeletal muscle; actin, alpha 1, skeletal muscle S homeolog; actin, alpha 2, smooth muscle, aorta; actin, alpha cardiac muscle 1; Actin, alpha cardiac muscle 1, intermediate form; Actin, alpha skeletal muscle; actin, alpha skeletal muscle S homeolog; Actin, alpha skeletal muscle, intermediate form; actin, alpha, cardiac 1; actin, alpha, cardiac muscle; actin, alpha, cardiac muscle 1; actin, alpha, vascular smooth muscle; Actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; actin, beta; actin, beta L homeolog; actin, beta, cytoplasmic; actin, cytoplasmic 1; Actin, cytoplasmic 1, N-terminally processed; Actin, cytoplasmic 2; Actin, cytoplasmic 2, N-terminally processed; Actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1; actin, gamma 1 propeptide; actin, gamma 2; actin, gamma 2, smooth muscle, enteric; actin, gamma, cytoplasmic 1; actin, gamma-enteric smooth muscle; Actin, gamma-enteric smooth muscle, intermediate form; Actin/BAP47; Actin5C; Actin-5C; actin-like protein; Actl; ACTL3; Acts; ACTSA; ACTSG; Actsk-1; Actvs; Actx; AL023024; alpha 1 skeletal muscle actin; alpha actin; alpha actin 1; alpha actin 2; alpha-actin; alpha-actin cardiac; alpha-actin-1; Alpha-actin-2; alpha-actin-3; alphac-actin; Alpha-cardiac actin; alphaSMA; alpha-sma; alpha-smooth muscle actin; anon-EST:fe2D2; anon-fast-evolving-2D2; ArpA; ASD5; asma; a-SMA; Atcb; Bact; Bact; actin; B-actin; Bap47; beta actin; beta cytoskeletal actin; beta-actin; beta-actin FE-3; beta-actin/Bap47; BRWS1; BRWS2; cardiac actin; cardiac muscle alpha actin 1; cell growth-inhibiting gene 46 protein; cellular cytoskeletal beta-actin; CFTD; CFTD1; CFTDM; CG4027; CG4027-PA; CG4027-PB; CG4027-PC; CG4027-PD; CG4027-PE; chrX:5748184..5748304; CMD1R; CMH11; cyt5C; cytoplasmic 1; cytoplasmic 2; cytoplasmic actin; cytoplasmic beta-actin; cytoplasmic type 5; cytoskeletal beta actin; cytoskeletal gamma-actin; cytoskeletal protein; deafness, autosomal dominant 20; deafness, autosomal dominant 26; DFNA20; DFNA26; Dm-actin5C; Dmel\CG4027; Dmel_CG4027; E430023M04Rik; E51; epididymis luminal protein 176; F-actin; G-actin; gamma 1 propeptide; gamma non-muscle actin; gamma-2-actin; Gamma-actin; gamma-enteric smooth muscle actin; GIG46; HEL-176; hypothetical protein LOC515610; I79_002310; I79_013242; I79_019066; l(1)G0009; l(1)G0010; l(1)G0025; l(1)G0079; l(1)G0117; l(1)G0177; l(1)G0245; l(1)G0330; l(1)G0420; l(1)G0486; LOW QUALITY PROTEIN: actin, alpha skeletal muscle; LOW QUALITY PROTEIN: actin, aortic smooth muscle; LVNC4; M32055; mpfd; MYMY5; NEM1; NEM2; NEM3; nemaline myopathy type 3; pan actin; PS1TP5-binding protein 1; PS1TP5BP1; RE02927p; RP5-1068B5.2; SHPM; similar to b-actin; similar to beta actin; skeletal alpha actin; sma; SMalphaA; SMGA; smooth muscle alpha-actin; smooth muscle gamma-actin; T11; type 5; unnamed protein product; vascular smooth muscle alpha-actin; VSCM; wu:fb63d03; XELAEV_18029136mg; XELAEV_18045052mg

Host Species:
Mouse

Quantity:
50 μL

Primary or Secondary:
Primary

Target Species:
Bovine, Canine, Chicken, Fish, Goat, Guinea Pig, Hamster, Human, Mouse, Ovine, Porcine, Rabbit, Rat

Product Type:
Antibody

Isotype:
IgG2a

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MA124966

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Antigen:
beta Amyloid

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
P05067

Gene Symbols:
APP

Immunogen:
Synthetic peptide corresponding to residues 1-17 of human beta Amyloid.

Regulatory Status:
RUO

Gene ID (Entrez):
351

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
DE2B4

Conjugate:
Unconjugated

Gene:
APP

Gene Alias:
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid β; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTF gamma; CTF-alpha; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; OTTHUMP00000096096; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; PreA4 751; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2

Host Species:
Mouse

Quantity:
50 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1

Img

Thermo Scientific

MA1250

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Antigen:
CHOP

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide

Gene Accession No.:
P35638, P35639

Gene Symbols:
DDIT3

Immunogen:
A bacterially expressed, mouse CHOP fusion protein.

Regulatory Status:
RUO

Gene ID (Entrez):
13198, 1649

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
9C8

Conjugate:
Unconjugated

Gene:
DDIT3

Gene Alias:
C/EBP homologous protein; C/EBP homoologous protein 10; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP10; CHOP-10; Ddit3; DDIT-3; ddit3.L; DNA damage inducible transcript 3; DNA damage inducible transcript 3 L homeolog; DNA damage-inducible transcript 3 protein; DNA-damage inducible transcript 3; DNA-damage-inducible transcript 3; GADD153; growth arrest and DNA damage-inducible; growth arrest and DNA damage-inducible protein GADD153; Growth arrest and DNA-damage-inducible protein GADD153; MGC4154; transcription factor GADD153; Xchop; XELAEV_18013440mg

Host Species:
Mouse

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG2b