MA1721

GRK1 Monoclonal Antibody (D11), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 MA1721-Each-of-1 In Stock ₹ 42,737.22

MA1721 - Each of 1

₹ 42,737.22

In Stock

Quantity

1

Base Price: ₹ 42,737.22

GST (18%): ₹ 7,692.70

Total Price: ₹ 50,429.92

Antigen

GRK1

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

antibody with 0.05% sodium azide

Gene Accession No.

P28327, Q15835, Q9WVL4

Gene Symbols

GRK1

Immunogen

Full length human GRK1.

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Bovine, Human, Mouse

Product Type

Antibody

Isotype

IgG1

Applications

Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot

Clone

D11

Conjugate

Unconjugated

Gene

GRK1

Gene Alias

G protein-coupled receptor kinase 1; G protein-coupled receptpr kinase 1; GPRK1; G-protein coupled receptor kinase 1; G-protein receptor kinase 1; GRK 1a/b; GRK1; GRK1a; rhodopsin kinase; rhodopsin kinase GRK1; Rhok; RK

Host Species

Mouse

Purification Method

Protein G

Regulatory Status

RUO

Gene ID (Entrez)

24013, 281457, 6011

Content And Storage

-20° C, Avoid Freeze/Thaw Cycles

Form

Liquid

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Description

  • MA1-721 detects G-protein-associated rhodopsin kinase 1a/b (GRK1a/b) from human and bovine tissues
  • This antibody does not cross-react with other G protein-coupled kinases
  • MA1-721 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation experiments
  • By Western blot, this antibody detects an ∽60 kDa protein representing GRK 1a/b
  • MA1-721 detects both in vitro expressed splice variants by Western blot but was not able to detect significant amounts of GRK1b from human retina
  • Immunofluorescence staining of GRK1a/b in bovine retina with MA1-721 results in intense staining primarily in cone outer segments, but also in rod outer segments
  • Weak staining is observed in somata and synaptic terminals of cones and inner segments of rods
  • The MA1-721 immunogen is full length human GRK1a
  • This antibody recognizes an N-terminal epitope of human GRK1 which is conserved in both GRK1a and GRK1b
  • GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases
  • GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation
  • Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2)
  • GRK1 can be phosphorylated by PKA and this reduces the ability of GRK1 to phosphorylate rhodopsin in vitro
  • It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated.

Compare Similar Items

Show Difference

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Thermo Scientific

MA1721

--


Antigen:
GRK1

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
antibody with 0.05% sodium azide

Gene Accession No.:
P28327, Q15835, Q9WVL4

Gene Symbols:
GRK1

Immunogen:
Full length human GRK1.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Bovine, Human, Mouse

Product Type:
Antibody

Isotype:
IgG1

Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot

Clone:
D11

Conjugate:
Unconjugated

Gene:
GRK1

Gene Alias:
G protein-coupled receptor kinase 1; G protein-coupled receptpr kinase 1; GPRK1; G-protein coupled receptor kinase 1; G-protein receptor kinase 1; GRK 1a/b; GRK1; GRK1a; rhodopsin kinase; rhodopsin kinase GRK1; Rhok; RK

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
24013, 281457, 6011

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

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MA1723

--


Antigen:
RGS9

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide

Gene Accession No.:
O46469, O54828

Gene Symbols:
RGS9

Immunogen:
Full length, bacterially expressed RGS9-1.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Bovine, Mouse

Product Type:
Antibody

Isotype:
IgG1

Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot

Clone:
D7

Conjugate:
Unconjugated

Gene:
RGS9

Gene Alias:
GTPase accelerating protein for heterotrimeric G-proteins; MGC111763; MGC26458; PERRS; regulator of G protein signaling 9; regulator of G protein signaling 9; regulator of G-protein signaling 9; regulator of G-protein signaling 9; regulator of G-protein signalling 9; Rgs9; RGS9-1; Rgs9-2; RGS9L; ROS GAP

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
19739, 281453

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

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MA1724

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Antigen:
GCAP1

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide

Gene Accession No.:
P43080, P46065

Gene Symbols:
Guca1a

Immunogen:
Bacterial expressed full length GCAP-1.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Bovine, Human, Non-human Primate

Product Type:
Antibody

Isotype:
IgG2a

Applications:
Western Blot

Clone:
G2

Conjugate:
Unconjugated

Gene:
Guca1a

Gene Alias:
C6orf131; COD3; cone dystrophy 3; CORD14; GC-A; GCAP; GCAP 1; GCAP1; Guanylate cyclase activator 1A; guanylate cyclase activator 1a (retina); guanylate cyclase-activating protein, photoreceptor 1; guanylin 1, retina; guanylyl cyclase-activating protein; guanylyl cyclase-activating protein 1; GUCA; GUCA1; GUCA1A; mGCAP1

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
282243, 2978

Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles

Form:
Liquid

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MA172500

--


Antigen:
FCAR (soluble)

Classification:
Monoclonal

Concentration:
1 mg/mL

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
P24071

Gene Symbols:
Fcar

Immunogen:
Recombinant soluble CD89.

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1

Applications:
Flow Cytometry, Inhibition Assays, Radioimmune Assays (RIA)

Clone:
MIP7c

Conjugate:
Unconjugated

Gene:
Fcar

Gene Alias:
CD89; CTB-61M7.2; Fc alpha receptor; Fc fragment of IgA receptor; Fc fragment of IgA, receptor for; FcalphaRI; FCAR; IgA Fc receptor; immunoglobulin A Fc receptor; immunoglobulin A Fc receptor transcript variant 1; immunoglobulin A Fc receptor transcript variant 3; immunoglobulin A Fc receptor transcript variant 7; immunoglobulin A Fc receptor transcript variant 9; immunoglobulin A Fc receptor transcript variant deltaEC1; immunoglobulin A Fc receptor transcript variant deltaEC1 delta TM/C; immunoglobulin alpha Fc receptor

Host Species:
Mouse

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
2204

Content And Storage:
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Form:
Liquid