MABE1819100
XPD, Mouse anti-Human, Clone: 22TF2-2F6, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1819100-Each-of-1 | In Stock | ₹ 42,676.47 |
MABE1819100 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,676.47
GST (18%): ₹ 7,681.765
Total Price: ₹ 50,358.235
Antigen
XPD
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
ERCC2;XPD;XPDC
Immunogen
Ovalbumin-conjugated linear peptide corresponding to 32 amino acids from the C-terminal region of human General transcription and DNA repair factor IIH helicase subunit XPD (XPD/ERCC2).
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_000391.1
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
22TF2-2F6
Dilution
Western Blotting Analysis: A representative lot detected XPD in Western Blotting applications (Alekseev, S., et. al. (2017). Mol Cell. 65(3):504-514.e4).Immunocytochemistry Analysis: A representative lot detected XPD in Immunocytochmeistry applications (Vermeulen, W., et. al. (2000). Nat Genet. 26(3):307-13). .Immunoprecipitation Analysis: A representative lot immunoprecipitated XPD in Immunoprecipitation applications (Coin, F., et. al. (1998). Nat Genet. 20(2):184-8; Seroz, T., et. al. (2000). Nucleic Acids Res. 28(22):4506-13).
Gene Alias
General transcription and DNA repair factor IIH helicase subunit XPD;EC: 3.6.4.12;TFIIH subunit XPD;Basic transcription factor 2 80 kDa subunit;BTF2 p80;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;TFIIH basal transcription factor complex 80 kDa subunit;TFIIH 80 kDa subunit;TFIIH p80;Xeroderma pigmentosum group D-complementing protein
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 22TF2-2F6 detects General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) in human cells. It targets an epitope with in 32 amino acids from the C-terminal region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anti-XPD, clone 22TF2-2F6, Cat
- No
- MABE1819, is a highly specific mouse monoclonal antibody that targets human General transcription and DNA repair factor IIH helicase subunit XPD and has been tested for use in Immunocytochemistry, Immunoprecipitation, and Western Blotting
- General transcription and DNA repair factor IIH helicase subunit XPD (UniProt: P18074; also known as EC: 3.6.4.12, TFIIH subunit XPD, Basic transcription factor 2 80 kDa subunit, BTF2 p80, CXPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH 80 kDa subunit, TFIIH p80, Xeroderma pigmentosum group D-complementing protein) is encoded by the ERCC2 (also known as XPD, XPDC) gene (Gene ID: 2068) in human
- XPD is an ATP-dependent 5'-3' DNA helicase component of the general transcription and DNA repair factor IIH (TFIIH) core complex that is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA
- Its ATP-binding region is localized to amino acids 7-283 and its nuclear localization is in amino acids 682-695
- In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment
- In transcription, TFIIH plays an essential role in transcription initiation
- When the pre-initiation complex has been established, TFIIH is required for promoter opening and promoter escape
- Phosphorylation of the C-terminal tail of the largest subunit of RNA polymerase II by CDK-activating kinase (CAK) complex controls the initiation of transcription
- XPD acts by forming a bridge between CAK and the core-TFIIH complex
- Mutations in ERCC2 gene are known to cause Xeroderma pigmentosum complementation group D that is characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities
- The skin develops marked freckling and other pigmentation abnormalities.
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Show Difference
Antigen: XPD
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: ERCC2;XPD;XPDC
Immunogen: Ovalbumin-conjugated linear peptide corresponding to 32 amino acids from the C-terminal region of human General transcription and DNA repair factor IIH helicase subunit XPD (XPD/ERCC2).
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_000391.1
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 22TF2-2F6
Dilution: Western Blotting Analysis: A representative lot detected XPD in Western Blotting applications (Alekseev, S., et. al. (2017). Mol Cell. 65(3):504-514.e4).Immunocytochemistry Analysis: A representative lot detected XPD in Immunocytochmeistry applications (Vermeulen, W., et. al. (2000). Nat Genet. 26(3):307-13). .Immunoprecipitation Analysis: A representative lot immunoprecipitated XPD in Immunoprecipitation applications (Coin, F., et. al. (1998). Nat Genet. 20(2):184-8; Seroz, T., et. al. (2000). Nucleic Acids Res. 28(22):4506-13).
Gene Alias: General transcription and DNA repair factor IIH helicase subunit XPD;EC: 3.6.4.12;TFIIH subunit XPD;Basic transcription factor 2 80 kDa subunit;BTF2 p80;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;TFIIH basal transcription factor complex 80 kDa subunit;TFIIH 80 kDa subunit;TFIIH p80;Xeroderma pigmentosum group D-complementing protein
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 22TF2-2F6 detects General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) in human cells. It targets an epitope with in 32 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
XPD
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
ERCC2;XPD;XPDC
Immunogen:
Ovalbumin-conjugated linear peptide corresponding to 32 amino acids from the C-terminal region of human General transcription and DNA repair factor IIH helicase subunit XPD (XPD/ERCC2).
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_000391.1
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
22TF2-2F6
Dilution:
Western Blotting Analysis: A representative lot detected XPD in Western Blotting applications (Alekseev, S., et. al. (2017). Mol Cell. 65(3):504-514.e4).Immunocytochemistry Analysis: A representative lot detected XPD in Immunocytochmeistry applications (Vermeulen, W., et. al. (2000). Nat Genet. 26(3):307-13). .Immunoprecipitation Analysis: A representative lot immunoprecipitated XPD in Immunoprecipitation applications (Coin, F., et. al. (1998). Nat Genet. 20(2):184-8; Seroz, T., et. al. (2000). Nucleic Acids Res. 28(22):4506-13).
Gene Alias:
General transcription and DNA repair factor IIH helicase subunit XPD;EC: 3.6.4.12;TFIIH subunit XPD;Basic transcription factor 2 80 kDa subunit;BTF2 p80;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;TFIIH basal transcription factor complex 80 kDa subunit;TFIIH 80 kDa subunit;TFIIH p80;Xeroderma pigmentosum group D-complementing protein
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 22TF2-2F6 detects General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) in human cells. It targets an epitope with in 32 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: XPD
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: ERCC2;XPD;XPDC
Immunogen: Ovalbumin-conjugated linear peptide corresponding to 32 amino acids from the C-terminal region of human General transcription and DNA repair factor IIH helicase subunit XPD (XPD/ERCC2).
Quantity: 25 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_000391.1
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 22TF2-2F6
Dilution: Western Blotting Analysis: A representative lot detected XPD in Western Blotting applications (Alekseev, S., et. al. (2017). Mol Cell. 65(3):504-514.e4).Immunocytochemistry Analysis: A representative lot detected XPD in Immunocytochmeistry applications (Vermeulen, W., et. al. (2000). Nat Genet. 26(3):307-13). .Immunoprecipitation Analysis: A representative lot immunoprecipitated XPD in Immunoprecipitation applications (Coin, F., et. al. (1998). Nat Genet. 20(2):184-8; Seroz, T., et. al. (2000). Nucleic Acids Res. 28(22):4506-13).
Gene Alias: General transcription and DNA repair factor IIH helicase subunit XPD;EC: 3.6.4.12;TFIIH subunit XPD;Basic transcription factor 2 80 kDa subunit;BTF2 p80;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;TFIIH basal transcription factor complex 80 kDa subunit;TFIIH 80 kDa subunit;TFIIH p80;Xeroderma pigmentosum group D-complementing protein
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 22TF2-2F6 detects General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) in human cells. It targets an epitope with in 32 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
XPD
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
ERCC2;XPD;XPDC
Immunogen:
Ovalbumin-conjugated linear peptide corresponding to 32 amino acids from the C-terminal region of human General transcription and DNA repair factor IIH helicase subunit XPD (XPD/ERCC2).
Quantity:
25 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_000391.1
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
22TF2-2F6
Dilution:
Western Blotting Analysis: A representative lot detected XPD in Western Blotting applications (Alekseev, S., et. al. (2017). Mol Cell. 65(3):504-514.e4).Immunocytochemistry Analysis: A representative lot detected XPD in Immunocytochmeistry applications (Vermeulen, W., et. al. (2000). Nat Genet. 26(3):307-13). .Immunoprecipitation Analysis: A representative lot immunoprecipitated XPD in Immunoprecipitation applications (Coin, F., et. al. (1998). Nat Genet. 20(2):184-8; Seroz, T., et. al. (2000). Nucleic Acids Res. 28(22):4506-13).
Gene Alias:
General transcription and DNA repair factor IIH helicase subunit XPD;EC: 3.6.4.12;TFIIH subunit XPD;Basic transcription factor 2 80 kDa subunit;BTF2 p80;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;TFIIH basal transcription factor complex 80 kDa subunit;TFIIH 80 kDa subunit;TFIIH p80;Xeroderma pigmentosum group D-complementing protein
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 22TF2-2F6 detects General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) in human cells. It targets an epitope with in 32 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: phospho-HDAC1 (Ser406)
Classification: Monoclonal
Conjugate: KLH
Formulation: __
Gene Symbols: HDAC1, RPD3L1
Immunogen: KLH-conjugated linear peptide corresponding to 19 amino acids surrounding phosphoserine 406 from the C-terminal region of human Histone deacetylase 1.
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: Human, Bovine, Monkey, Rat, Rabbit
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: BT-15
Dilution: __
Gene Alias: Histone deacetylase 1;HD1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: Clone BT-15 is a mouse monoclonal antibody that specifically detects Histone deacetylase phosphorylated on serine 406 in mitotic synchronized cells. It targets an epitope within 19 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2 to 8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
phospho-HDAC1 (Ser406)
Classification:
Monoclonal
Conjugate:
KLH
Formulation:
__
Gene Symbols:
HDAC1, RPD3L1
Immunogen:
KLH-conjugated linear peptide corresponding to 19 amino acids surrounding phosphoserine 406 from the C-terminal region of human Histone deacetylase 1.
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
Human, Bovine, Monkey, Rat, Rabbit
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
BT-15
Dilution:
__
Gene Alias:
Histone deacetylase 1;HD1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
Clone BT-15 is a mouse monoclonal antibody that specifically detects Histone deacetylase phosphorylated on serine 406 in mitotic synchronized cells. It targets an epitope within 19 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2 to 8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: phospho-HDAC1 (Ser406)
Classification: Monoclonal
Conjugate: KLH
Formulation: __
Gene Symbols: HDAC1, RPD3L1
Immunogen: KLH-conjugated linear peptide corresponding to 19 amino acids surrounding phosphoserine 406 from the C-terminal region of human Histone deacetylase 1.
Quantity: 25 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: Human, Bovine, Monkey, Rat, Rabbit
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: BT-15
Dilution: __
Gene Alias: Histone deacetylase 1;HD1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: Clone BT-15 is a mouse monoclonal antibody that specifically detects Histone deacetylase phosphorylated on serine 406 in mitotic synchronized cells. It targets an epitope within 19 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2 to 8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
phospho-HDAC1 (Ser406)
Classification:
Monoclonal
Conjugate:
KLH
Formulation:
__
Gene Symbols:
HDAC1, RPD3L1
Immunogen:
KLH-conjugated linear peptide corresponding to 19 amino acids surrounding phosphoserine 406 from the C-terminal region of human Histone deacetylase 1.
Quantity:
25 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
Human, Bovine, Monkey, Rat, Rabbit
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
BT-15
Dilution:
__
Gene Alias:
Histone deacetylase 1;HD1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
Clone BT-15 is a mouse monoclonal antibody that specifically detects Histone deacetylase phosphorylated on serine 406 in mitotic synchronized cells. It targets an epitope within 19 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2 to 8°C from date of receipt.
Isotype:
IgG2b κ