MABF218225
CD46, Mouse anti-Human, Clone: TRA-2-10, Millipore Sigma™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF218225-Each-of-1 | In Stock | ₹ 16,456.61 |
MABF218225 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
CD46
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in PBS without preservatives.
Gene Symbols
CD46;MCP;MIC10
Immunogen
2102Ep human embryonal carcinoma cells.
Quantity
25 μL
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_002380
Target Species
Human
Form
Purified
Applications
Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone
TRA-2-10
Dilution
Inhibition Analysis: A representative lot blocked Measles virus infection in BC1 cells. (Manchester, M., et. al. (1995). Proc Natl Acad Sci U S A. 92(6):2303-7). Immunohistochemistry Analysis: A representative lot detected CD46 in Immunohistochemistry applications (Kemper, C., et. al. (2001). Clin Exp Immunol. 124(2):180-9).Immunoprecipitation Analysis: A representative lot immunoprecipitated CD46 in Immunoprecipitation applications (Andrews, P.W., et. al. (1985). Ann Hum Genet. 49(Pt 1):31-9).Flow Cytometry Analysis: A representative lot detected CD46 in Flow Cytometry applications (Manchester, M., et. al. (1995). Proc Natl Acad Sci U S A. 92(6):2303-7).
Gene Alias
Membrane cofactor protein;TLX;Trophoblast leukocyte common antigen
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone TRA-2-10 specifically detects CD46 in human cells.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG1 κ
Related Products
Description
- Anti-CD46, clone TRA-2-10, Cat
- No
- MABF2182, is a mouse monoclonal antibody that detects Membrane cofactor protein (CD46) and has been for use in Flow Cytometry, Immunoprecipitation, Immunohistochemistry, and Inhibition assay
- Membrane cofactor protein (UniProt: P15529; also known as TLX, Trophoblast leukocyte common antigen, CD46) is encoded by the CD46 (also known as MCP; MIC10) gene (Gene ID: 4179) in human
- CD46 is a single-pass type I membrane protein that is expressed by all cells except erythrocytes
- It acts as a cofactor for complement factor I, a serine protease that protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue
- It also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells
- CD46 is synthesized with a signal peptide (aa 1-34), which is cleaved off in the mature form
- The mature form contains an extracellular domain (aa 35-343), a transmembrane domain (aa 344-366), and a cytoplasmic domain (aa 367-392)
- It also contains four Sushi domains where Sushi domains 1 and 2 are required for interaction with human adenovirus B PIV/FIBER protein and with Measles Virus H protein, domains 2 and 3 are essential for Herpes virus 6 binding, and domains 3 and 4 are required for interaction with Streptococcus Pyrogens M protein and are the most important for interaction with C3b and C4b
- CD46 can be glycosylated on Asn 83, 114, and 273 and N-glycosylation on Asn 114 and 273 are required for its cytoprotective function
- N-glycosylation on Asn 114 is also required for Measles virus binding and N-glycosylation on Asn-273 is required for Neisseria binding
- CD46 can also be extensively O-glycosylated in the Ser/Thr-rich domain, which is required for Neisseria binding, but not for Measles virus binding
- Mutations in CD46 gene have been linked to hemolytic uremic syndrome atypical 2 that has been characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal failure.
Compare Similar Items
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Antigen: CD46
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in PBS without preservatives.
Gene Symbols: CD46;MCP;MIC10
Immunogen: 2102Ep human embryonal carcinoma cells.
Quantity: 25 μL
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_002380
Target Species: Human
Form: Purified
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone: TRA-2-10
Dilution: Inhibition Analysis: A representative lot blocked Measles virus infection in BC1 cells. (Manchester, M., et. al. (1995). Proc Natl Acad Sci U S A. 92(6):2303-7). Immunohistochemistry Analysis: A representative lot detected CD46 in Immunohistochemistry applications (Kemper, C., et. al. (2001). Clin Exp Immunol. 124(2):180-9).Immunoprecipitation Analysis: A representative lot immunoprecipitated CD46 in Immunoprecipitation applications (Andrews, P.W., et. al. (1985). Ann Hum Genet. 49(Pt 1):31-9).Flow Cytometry Analysis: A representative lot detected CD46 in Flow Cytometry applications (Manchester, M., et. al. (1995). Proc Natl Acad Sci U S A. 92(6):2303-7).
Gene Alias: Membrane cofactor protein;TLX;Trophoblast leukocyte common antigen
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone TRA-2-10 specifically detects CD46 in human cells.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Antigen:
CD46
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in PBS without preservatives.
Gene Symbols:
CD46;MCP;MIC10
Immunogen:
2102Ep human embryonal carcinoma cells.
Quantity:
25 μL
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_002380
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone:
TRA-2-10
Dilution:
Inhibition Analysis: A representative lot blocked Measles virus infection in BC1 cells. (Manchester, M., et. al. (1995). Proc Natl Acad Sci U S A. 92(6):2303-7). Immunohistochemistry Analysis: A representative lot detected CD46 in Immunohistochemistry applications (Kemper, C., et. al. (2001). Clin Exp Immunol. 124(2):180-9).Immunoprecipitation Analysis: A representative lot immunoprecipitated CD46 in Immunoprecipitation applications (Andrews, P.W., et. al. (1985). Ann Hum Genet. 49(Pt 1):31-9).Flow Cytometry Analysis: A representative lot detected CD46 in Flow Cytometry applications (Manchester, M., et. al. (1995). Proc Natl Acad Sci U S A. 92(6):2303-7).
Gene Alias:
Membrane cofactor protein;TLX;Trophoblast leukocyte common antigen
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone TRA-2-10 specifically detects CD46 in human cells.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Antigen: Dengue Virus 2 NS1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: __
Immunogen: Purified recombinant Dengue virus 2 NS1 protein expressed in mammalian cells.
Quantity: 100 μg
Research Discipline: Inflammation and Immunology
Gene ID (Entrez): __
Target Species: Virus
Form: Purified
Applications: ELISA, Flow Cytometry
Clone: 243
Dilution: __
Gene Alias: DENV NS1 protein
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: Clone 243 is a mouse monoclonal antibody that specifically detects Dengue virus 2 NS1 protein. It targets an epitope within 18 amino acids from the beta-ladder region.
Content And Storage: Stable for 1 year at 2 to 8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Dengue Virus 2 NS1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
__
Immunogen:
Purified recombinant Dengue virus 2 NS1 protein expressed in mammalian cells.
Quantity:
100 μg
Research Discipline:
Inflammation and Immunology
Gene ID (Entrez):
__
Target Species:
Virus
Form:
Purified
Applications:
ELISA, Flow Cytometry
Clone:
243
Dilution:
__
Gene Alias:
DENV NS1 protein
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
Clone 243 is a mouse monoclonal antibody that specifically detects Dengue virus 2 NS1 protein. It targets an epitope within 18 amino acids from the beta-ladder region.
Content And Storage:
Stable for 1 year at 2 to 8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Dengue Virus 2 NS1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: __
Immunogen: Purified recombinant Dengue virus 2 NS1 protein expressed in mammalian cells.
Quantity: 25 μg
Research Discipline: Inflammation and Immunology
Gene ID (Entrez): __
Target Species: Virus
Form: Purified
Applications: ELISA, Flow Cytometry
Clone: 243
Dilution: __
Gene Alias: DENV NS1 protein
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: Clone 243 is a mouse monoclonal antibody that specifically detects Dengue virus 2 NS1 protein. It targets an epitope within 18 amino acids from the beta-ladder region.
Content And Storage: Stable for 1 year at 2 to 8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Dengue Virus 2 NS1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
__
Immunogen:
Purified recombinant Dengue virus 2 NS1 protein expressed in mammalian cells.
Quantity:
25 μg
Research Discipline:
Inflammation and Immunology
Gene ID (Entrez):
__
Target Species:
Virus
Form:
Purified
Applications:
ELISA, Flow Cytometry
Clone:
243
Dilution:
__
Gene Alias:
DENV NS1 protein
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
Clone 243 is a mouse monoclonal antibody that specifically detects Dengue virus 2 NS1 protein. It targets an epitope within 18 amino acids from the beta-ladder region.
Content And Storage:
Stable for 1 year at 2 to 8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Dengue Virus 4 NS1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: __
Immunogen: Purified recombinant Dengue virus NS1 protein expressed in mammalian cells.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Virus
Form: Purified
Applications: ELISA, Flow Cytometry
Clone: 626
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
Dengue Virus 4 NS1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
Purified recombinant Dengue virus NS1 protein expressed in mammalian cells.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Virus
Form:
Purified
Applications:
ELISA, Flow Cytometry
Clone:
626
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ