MABN247125
Aquaporin-4, Mouse anti-Rat, Human, Mouse, Clone: mECD, Millipore Sigma™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN247125-Each-of-1 | In Stock | ₹ 16,550.73 |
MABN247125 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,550.73
GST (18%): ₹ 2,979.131
Total Price: ₹ 19,529.861
Antigen
Aquaporin-4
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in PBS without preservatives.
Gene Symbols
AQP4
Immunogen
His-tagged full-length human recombinant Aquaporin-4.
Quantity
25 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001641
Target Species
Rat, Human, Mouse
Form
Purified
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Clone
mECD
Dilution
Flow Cytometry Analysis: A representative lot detected Aquaporin-4 in Flow Cytometry applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).Immunofluorescence Analysis: A representative lot detected Aquaporin-4 in Immunofluorescence applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).Immunoprecipitation Analysis: A representative lot immunoprecipitated Aquaporin-4 in Immunoprcipitation applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).
Gene Alias
AQP-4;Mercurial-insensitive water channel;MIWC;WCH4
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone mECD specifically detects Aquaporin-4 in human, mouse, and rat brain tissue sections. It targets an epitope with in the extracellular region.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG1 κ
Related Products
Description
- Anti-Aquaporin-4, clone mECD, Cat
- No
- MABN2471, is a highly specific mouse monoclonal antibody that targets Aquaporin-4 and has been tested for use in Flow Cytometry, Immunohistochemistry, Immunofluorescence, and Immunoprecipitation
- Aquaporin-4 (UniProt: P55087; also known as AQP-4, Mercurial-insensitive water channel, MIWC, WCH4) is encoded by the AGP4 gene (Gene ID: 361) in human
- Aquaporin-4 is a multi-pass membrane protein that forms a water-specific channel and serves as an osmoreceptor that regulates body water balance and mediates water flow within the central nervous system
- Its extracellular domains are localized to amino acids 58-64, 137-155, and 206-231); its transmembrane domains are in amino acids 37-57, 65-85, 116-136, 156-176, 185-205, and 232-252); and the cytoplasmic domain is in amino acids 1-36, 86-115, 177-184, and 253-323)
- Aquaporin-4 is largely expressed in the brain and the skeletal muscle and at lower levels in heart, kidney, and lung tissue
- Phosphorylation of Aquaporin-4 at Serine 180 by protein kinase C is shown to reduce conductance by about 50%, whereas phosphorylation at Serine 111 by protein kinase G in response to glutamate can increase conductance by about 40%
- Two isoforms of Aquaporin-4 have been described that are produced by alternative splicing
- Antibodies to Aquaporin-4 can serve as useful serum markers to distinguishing neuromyelitis optica (NMO) from multiple sclerosis
- Clone mECD is shown to induce clustering and internalization of Aquporin-4 and cause its redistribution, which is also observed with NMO-IgG
- Exposure to mECD antibody is also shown to cause coaggregation of astrocytic CD28B and Aquaporin-4
- (Ref.: Hinson, SR et al
- (2017)
- Proc
- Natl.Acad
- Sci
- USA 114(21); 5491-5496).
Compare Similar Items
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Antigen: Aquaporin-4
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in PBS without preservatives.
Gene Symbols: AQP4
Immunogen: His-tagged full-length human recombinant Aquaporin-4.
Quantity: 25 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001641
Target Species: Rat, Human, Mouse
Form: Purified
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Clone: mECD
Dilution: Flow Cytometry Analysis: A representative lot detected Aquaporin-4 in Flow Cytometry applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).Immunofluorescence Analysis: A representative lot detected Aquaporin-4 in Immunofluorescence applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).Immunoprecipitation Analysis: A representative lot immunoprecipitated Aquaporin-4 in Immunoprcipitation applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).
Gene Alias: AQP-4;Mercurial-insensitive water channel;MIWC;WCH4
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone mECD specifically detects Aquaporin-4 in human, mouse, and rat brain tissue sections. It targets an epitope with in the extracellular region.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Antigen:
Aquaporin-4
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in PBS without preservatives.
Gene Symbols:
AQP4
Immunogen:
His-tagged full-length human recombinant Aquaporin-4.
Quantity:
25 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001641
Target Species:
Rat, Human, Mouse
Form:
Purified
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Clone:
mECD
Dilution:
Flow Cytometry Analysis: A representative lot detected Aquaporin-4 in Flow Cytometry applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).Immunofluorescence Analysis: A representative lot detected Aquaporin-4 in Immunofluorescence applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).Immunoprecipitation Analysis: A representative lot immunoprecipitated Aquaporin-4 in Immunoprcipitation applications (Hinson, S.R., et. al. (2017). Proc Natl Acad Sci USA. 114(21):5491-5496).
Gene Alias:
AQP-4;Mercurial-insensitive water channel;MIWC;WCH4
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone mECD specifically detects Aquaporin-4 in human, mouse, and rat brain tissue sections. It targets an epitope with in the extracellular region.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Antigen: Tau
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: MAPT;MAPTL;MTBT1;TAU
Immunogen: KLH-conjugated linear peptide corresponding to 19 amino acids from the N-terminal half of human Microtubule-associated protein tau.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_058519
Target Species: Mouse, Human
Form: Purified
Applications: Immunohistochemistry, Western Blot
Clone: 2A1-2E1
Dilution: __
Gene Alias: Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 2A1-2E1 detects Microtubule-associated protein tau in human and murine brain. It targets an epitope within 19 amino acids from the N-termnal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Tau
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
MAPT;MAPTL;MTBT1;TAU
Immunogen:
KLH-conjugated linear peptide corresponding to 19 amino acids from the N-terminal half of human Microtubule-associated protein tau.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_058519
Target Species:
Mouse, Human
Form:
Purified
Applications:
Immunohistochemistry, Western Blot
Clone:
2A1-2E1
Dilution:
__
Gene Alias:
Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 2A1-2E1 detects Microtubule-associated protein tau in human and murine brain. It targets an epitope within 19 amino acids from the N-termnal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Tau
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: MAPT;MAPTL;MTBT1;TAU
Immunogen: KLH-conjugated linear peptide corresponding to 19 amino acids from the N-terminal half of human Microtubule-associated protein tau.
Quantity: 25 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_058519
Target Species: Mouse, Human
Form: Purified
Applications: Immunohistochemistry, Western Blot
Clone: 2A1-2E1
Dilution: __
Gene Alias: Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 2A1-2E1 detects Microtubule-associated protein tau in human and murine brain. It targets an epitope within 19 amino acids from the N-termnal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Tau
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
MAPT;MAPTL;MTBT1;TAU
Immunogen:
KLH-conjugated linear peptide corresponding to 19 amino acids from the N-terminal half of human Microtubule-associated protein tau.
Quantity:
25 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_058519
Target Species:
Mouse, Human
Form:
Purified
Applications:
Immunohistochemistry, Western Blot
Clone:
2A1-2E1
Dilution:
__
Gene Alias:
Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 2A1-2E1 detects Microtubule-associated protein tau in human and murine brain. It targets an epitope within 19 amino acids from the N-termnal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: NMDAR2B
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: GRIN2B;NMDAR2B
Immunogen: Full length purified human Glutamate receptor ionotropic, NMDA 2B (NMDAR2B).
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_000825
Target Species: Human, Mouse, Rat
Form: Purified
Applications: Western Blot
Clone: 11D1
Dilution: Western Blotting Analysis: A representative lot detected NMDAR2B in Western Blotting applications (Lu, W., et. al. (2017). Science. 355(6331)). Western Blotting Analysis: 4μg/mL from a representative lot detected NMDAR2B in mouse brain tissue lysate.
Gene Alias: Glutamate receptor ionotropic NMDA 2B;GluN2B;Glutamate [NMDA] receptor subunit epsilon-2;N-methyl D-aspartate receptor subtype 2B;NR2B;N-methyl-D-aspartate receptor subunit 3;NR3;hNR3
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 11D1 is a mouse monoclonal antibody that specifically detects NMDAR2B.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
NMDAR2B
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
GRIN2B;NMDAR2B
Immunogen:
Full length purified human Glutamate receptor ionotropic, NMDA 2B (NMDAR2B).
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_000825
Target Species:
Human, Mouse, Rat
Form:
Purified
Applications:
Western Blot
Clone:
11D1
Dilution:
Western Blotting Analysis: A representative lot detected NMDAR2B in Western Blotting applications (Lu, W., et. al. (2017). Science. 355(6331)). Western Blotting Analysis: 4μg/mL from a representative lot detected NMDAR2B in mouse brain tissue lysate.
Gene Alias:
Glutamate receptor ionotropic NMDA 2B;GluN2B;Glutamate [NMDA] receptor subunit epsilon-2;N-methyl D-aspartate receptor subtype 2B;NR2B;N-methyl-D-aspartate receptor subunit 3;NR3;hNR3
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 11D1 is a mouse monoclonal antibody that specifically detects NMDAR2B.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ