MABN2398100
Klotho, Rat anti-Human, Clone: KL-115, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN2398100-Each-of-1 | In Stock | ₹ 41,308.37 |
MABN2398100 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,308.37
GST (18%): ₹ 7,435.507
Total Price: ₹ 48,743.877
Antigen
Klotho
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Rat monoclonal antibody in ascites with 0.1% sodium azide with 50% glycerol.
Gene Symbols
KL
Immunogen
GST-tagged recombinant fragment corresponding to 207 amino acids from the extracellular domain from the N-terminal region of human Klotho.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_004786
Target Species
Human
Isotype
IgG2a κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
KL-115
Dilution
Western Blotting Analysis: A represetative lot detected Klotho in Western Blotting applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunocytochemistry Analysis: A represetative lot detected Klotho in Immunocytochemistry applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunoprecipitation Analysis: A represetative lot immunoprecipitated Klotho in Immunoprecipitation applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).
Gene Alias
EC: 3.2.1.31;KL
Host Species
Rat
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone KL-115 is a rat monoclonal antibody that specifically detects human Klotho. It targets an epitope with in 107 amino acids from the KL1 domain from the N-terminal region.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Related Products
Description
- Anti-Klotho, clone KL-115, Cat
- No
- MABN2398, is a highly specific rat monoclonal antibody that targets klotho and has been tested in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, and Western Blotting
- Klotho (UniProt: Q9UEF7; also known as EC: 3.2.1.31) is encoded by the KL gene (Gene ID:9365) in human
- Klotho is a homodimeric, highly N-glycosylated, single-pass type I membrane protein that is present in kidney, placenta, small intestine, and prostate tissue
- In kidney it is predominantly present in cortical renal tubules
- A soluble secreted form (isoform 2, ∽ 64 kDa) is present in serum and cerebrospinal fluid
- The Klotho peptide generated by cleavage of the membrane-bound isoform (Isoform 1) is considered as an anti-aging circulating hormone that is reported to extend life span by inhibiting insulin/IGF1 signaling
- It also acts as a cofactor for interaction of FGF23 with FGF R1, which negatively regulates the activity of 1-alpha-hydroxylase, the rate limiting enzyme in the synthesis of 1,25(OH)2D3
- Klotho is synthesized with a signal peptide (aa 1-33), which is subsequently cleaved off to generate the mature form that has an extracellular domain (aa 31-981), a short transmembrane domain (aa 982-1002), and a short cytoplasmic tail (aa 1003-1012)
- Deficiency of Klotho is reported to shorten life-span in animal models with a myriad of disorders associated with old age, such as arteriosclerosis, osteoporosis, and skin atrophy
- Klotho deficient mice also display severe hyperphosphatemia and soft tissue calcification
- On the contrary, over-expression of Klotho is shown to extend life-span in murine models by about 30% with side effects, such as mild insulin resistance and enhanced resistance to oxidative stress
- Defects in KL gene has been linked to chronic renal failure complications.
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Antigen: Klotho
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Rat monoclonal antibody in ascites with 0.1% sodium azide with 50% glycerol.
Gene Symbols: KL
Immunogen: GST-tagged recombinant fragment corresponding to 207 amino acids from the extracellular domain from the N-terminal region of human Klotho.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_004786
Target Species: Human
Isotype: IgG2a κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: KL-115
Dilution: Western Blotting Analysis: A represetative lot detected Klotho in Western Blotting applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunocytochemistry Analysis: A represetative lot detected Klotho in Immunocytochemistry applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunoprecipitation Analysis: A represetative lot immunoprecipitated Klotho in Immunoprecipitation applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).
Gene Alias: EC: 3.2.1.31;KL
Host Species: Rat
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone KL-115 is a rat monoclonal antibody that specifically detects human Klotho. It targets an epitope with in 107 amino acids from the KL1 domain from the N-terminal region.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen:
Klotho
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Rat monoclonal antibody in ascites with 0.1% sodium azide with 50% glycerol.
Gene Symbols:
KL
Immunogen:
GST-tagged recombinant fragment corresponding to 207 amino acids from the extracellular domain from the N-terminal region of human Klotho.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_004786
Target Species:
Human
Isotype:
IgG2a κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
KL-115
Dilution:
Western Blotting Analysis: A represetative lot detected Klotho in Western Blotting applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunocytochemistry Analysis: A represetative lot detected Klotho in Immunocytochemistry applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunoprecipitation Analysis: A represetative lot immunoprecipitated Klotho in Immunoprecipitation applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).
Gene Alias:
EC: 3.2.1.31;KL
Host Species:
Rat
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone KL-115 is a rat monoclonal antibody that specifically detects human Klotho. It targets an epitope with in 107 amino acids from the KL1 domain from the N-terminal region.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen: Klotho
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Rat monoclonal antibody in ascites with 0.1% sodium azide with 50% glycerol.
Gene Symbols: KL
Immunogen: GST-tagged recombinant fragment corresponding to 207 amino acids from the extracellular domain from the N-terminal region of human Klotho.
Quantity: 25 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_004786
Target Species: Human
Isotype: IgG2a κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: KL-115
Dilution: Western Blotting Analysis: A represetative lot detected Klotho in Western Blotting applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunocytochemistry Analysis: A represetative lot detected Klotho in Immunocytochemistry applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunoprecipitation Analysis: A represetative lot immunoprecipitated Klotho in Immunoprecipitation applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).
Gene Alias: EC: 3.2.1.31;KL
Host Species: Rat
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone KL-115 is a rat monoclonal antibody that specifically detects human Klotho. It targets an epitope with in 207 amino acids from the KL1 domain from the N-terminal region.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen:
Klotho
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Rat monoclonal antibody in ascites with 0.1% sodium azide with 50% glycerol.
Gene Symbols:
KL
Immunogen:
GST-tagged recombinant fragment corresponding to 207 amino acids from the extracellular domain from the N-terminal region of human Klotho.
Quantity:
25 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_004786
Target Species:
Human
Isotype:
IgG2a κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
KL-115
Dilution:
Western Blotting Analysis: A represetative lot detected Klotho in Western Blotting applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunocytochemistry Analysis: A represetative lot detected Klotho in Immunocytochemistry applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).Immunoprecipitation Analysis: A represetative lot immunoprecipitated Klotho in Immunoprecipitation applications (Maltare, A., et. al. (2014). Monoclon Antib Immunodiagn Immunoother. 33(6):420-7).
Gene Alias:
EC: 3.2.1.31;KL
Host Species:
Rat
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone KL-115 is a rat monoclonal antibody that specifically detects human Klotho. It targets an epitope with in 207 amino acids from the KL1 domain from the N-terminal region.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen: HSD17B10
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: HSD17B10;ERAB;HADH2;MRPP2;SCHAD;SDR5C1;XH98G2
Immunogen: GST-tagged full length recombinant human 3-hydroxyacyl-CoA dehydrogenase type-2 protein (ERAB/HADH).
Quantity: 25 μg
Research Discipline: Neuroscience
Gene ID (Entrez): __
Target Species: Mouse, Human
Isotype: IgG1 κ
Applications: Immunomicroscopy, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: 5F3
Dilution: __
Gene Alias: 3-hydroxyacyl-CoA dehydrogenase type-2;17-beta-hydroxysteroid dehydrogenase 10;17-beta-HSD 10;3-hydroxy-2-methylbutyryl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type II;Endoplasmic reticulum-associated amyloid beta-peptide-binding protein;Mitochondrial ribonuclease P protein 2;Mitochondrial RNase P protein 2;Short-chain type dehydrogenase/reductase XH98G2;Type II HADH
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 5F3 detects 3-hydroxyacyl-CoA dehydrogenase type-2 in human and murine cells.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Antigen:
HSD17B10
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
HSD17B10;ERAB;HADH2;MRPP2;SCHAD;SDR5C1;XH98G2
Immunogen:
GST-tagged full length recombinant human 3-hydroxyacyl-CoA dehydrogenase type-2 protein (ERAB/HADH).
Quantity:
25 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
__
Target Species:
Mouse, Human
Isotype:
IgG1 κ
Applications:
Immunomicroscopy, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
5F3
Dilution:
__
Gene Alias:
3-hydroxyacyl-CoA dehydrogenase type-2;17-beta-hydroxysteroid dehydrogenase 10;17-beta-HSD 10;3-hydroxy-2-methylbutyryl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type II;Endoplasmic reticulum-associated amyloid beta-peptide-binding protein;Mitochondrial ribonuclease P protein 2;Mitochondrial RNase P protein 2;Short-chain type dehydrogenase/reductase XH98G2;Type II HADH
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 5F3 detects 3-hydroxyacyl-CoA dehydrogenase type-2 in human and murine cells.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Antigen: __
Classification: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Isotype: __
Applications: __
Clone: __
Dilution: __
Gene Alias: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Antigen:
__
Classification:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Isotype:
__
Applications:
__
Clone:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__