MABT33625UG
TKS5, Mouse anti-Human, Clone: 13H6.3, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT33625UG-Each-of-1 | In Stock | ₹ 16,550.73 |
MABT33625UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,550.73
GST (18%): ₹ 2,979.131
Total Price: ₹ 19,529.861
Antigen
TKS5
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen
GST/His-tagged recombinant fragment corresponding to 60 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity
25 μg
Research Discipline
Cell Structure
Test Specificity
Clone 13H6.3 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 60 amino acids crom the C-terminal half.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
13H6.3
Dilution
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TKS5 in human breast cancer tissue.
Gene Alias
Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Anti-TKS5, clone 13H6.3, Cat
- No
- MABT336, ia a mouse monoclonal antibody that detects TKS5 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- SH3 and PX domain-containing protein 2A (UniProt: Q5TCZ1; also known as Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains) is encoded by the SH3PXD2A (also known as FISH, KIAA0418, SH3MD1, TKS5) gene (Gene ID: 9644) in human
- Adapter protein TKS5 is a scaffolding protein that is required for podosome formation, degradation of the extracellular matrix, and for invasion in some cancer cells
- Three isoforms of TKS5 have been described that are produced by alternative splicing
- TKS5 is a cytoplasmic protein in normal cells, but it localizes to podosomes in SRC-transformed cells
- It is found in several cancer cell lines, particularly invasive breast carcinomas and melanomas
- TKS5 contains one PX (phx homology) domain and five SH3 domains
- The PX domain is required for podosome localization because of its ability to bind phosphoinosiltols, such as PtdIns3P and PtdIns(3,4)P2 and to lesser extent PtdIns5P and PtdIns(3,5)P2
- Its binding with ADAM12, ADAM15 and ADAM19 is mediated by the fifth SH3 domain
- The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region.
Compare Similar Items
Show Difference
Antigen: TKS5
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen: GST/His-tagged recombinant fragment corresponding to 60 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity: 25 μg
Research Discipline: Cell Structure
Test Specificity: Clone 13H6.3 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 60 amino acids crom the C-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 13H6.3
Dilution: Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TKS5 in human breast cancer tissue.
Gene Alias: Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
TKS5
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen:
GST/His-tagged recombinant fragment corresponding to 60 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity:
25 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone 13H6.3 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 60 amino acids crom the C-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
13H6.3
Dilution:
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TKS5 in human breast cancer tissue.
Gene Alias:
Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: This mouse monoclonal TKS5
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen: GST/His-tagged recombinant fragment corresponding to 91 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity: 25 μg
Research Discipline: Cell Structure
Test Specificity: Clone 9H2.1 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 91 amino acids crom the C-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot
Clone: 9H2.1
Dilution: __
Gene Alias: Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
This mouse monoclonal TKS5
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen:
GST/His-tagged recombinant fragment corresponding to 91 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity:
25 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone 9H2.1 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 91 amino acids crom the C-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
9H2.1
Dilution:
__
Gene Alias:
Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: phospho-cytokeratin-8 (K8) (Ser431)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: KRT8;CYK8
Immunogen: Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity: 100 μg
Research Discipline: Cell Structure
Test Specificity: Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunofluorescence, Western Blot
Clone: 5B3
Dilution: Immunofluorescence Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Immunofluorescence applications (Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).Western Blotting Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Western Blotting applications (Yoon, K.H., et. al. (2001). J Cell Biol. 153(3):503-16; Ridge, K.M., et. al. (2005). J Biol Chem. 280(34):30400-5; Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).
Gene Alias: Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
phospho-cytokeratin-8 (K8) (Ser431)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
KRT8;CYK8
Immunogen:
Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity:
100 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunofluorescence, Western Blot
Clone:
5B3
Dilution:
Immunofluorescence Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Immunofluorescence applications (Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).Western Blotting Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Western Blotting applications (Yoon, K.H., et. al. (2001). J Cell Biol. 153(3):503-16; Ridge, K.M., et. al. (2005). J Biol Chem. 280(34):30400-5; Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).
Gene Alias:
Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Antigen: phospho-cytokeratin-8 (K8) (Ser431)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: KRT8;CYK8
Immunogen: Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity: 25 μg
Research Discipline: Cell Structure
Test Specificity: Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunofluorescence, Western Blot
Clone: 5B3
Dilution: Immunofluorescence Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Immunofluorescence applications (Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).Western Blotting Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Western Blotting applications (Yoon, K.H., et. al. (2001). J Cell Biol. 153(3):503-16; Ridge, K.M., et. al. (2005). J Biol Chem. 280(34):30400-5; Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).
Gene Alias: Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
phospho-cytokeratin-8 (K8) (Ser431)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
KRT8;CYK8
Immunogen:
Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity:
25 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunofluorescence, Western Blot
Clone:
5B3
Dilution:
Immunofluorescence Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Immunofluorescence applications (Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).Western Blotting Analysis: A representative lot detected phospho-cytokeratin-8 (K8) (Ser431) in Western Blotting applications (Yoon, K.H., et. al. (2001). J Cell Biol. 153(3):503-16; Ridge, K.M., et. al. (2005). J Biol Chem. 280(34):30400-5; Ku, N.O., et. al. (1997). J Biol Chem. 272(11):7556-64).
Gene Alias:
Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified