MABT33725UG
This mouse monoclonal TKS5, Mouse anti-Human, Clone: 9H2.1, Millipore Sigma™
Manufacturer: MilliporeSigma
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT33725UG-Each-of-1 | In Stock | ₹ 15,999.72 |
MABT33725UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,999.72
GST (18%): ₹ 2,879.95
Total Price: ₹ 18,879.67
Antigen
This mouse monoclonal TKS5
Classification
Monoclonal
Conjugate
Unconjugated
Gene Alias
Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
9H2.1
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen
GST/His-tagged recombinant fragment corresponding to 91 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity
25 μg
Research Discipline
Cell Structure
Test Specificity
Clone 9H2.1 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 91 amino acids crom the C-terminal half.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- This mouse monoclonal Anti-TKS5, clone 9H2.1, Cat
- No
- MABT337, is a mouse monoclonal antibody that detects SH3 and PX domain-containing protein 2A (TKS5) and has been tested for use in Western Blotting
- SH3 and PX domain-containing protein 2A (UniProt: Q5TCZ1; also known as Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains) is encoded by the SH3PXD2A (also known as FISH, KIAA0418, SH3MD1, TKS5) gene (Gene ID: 9644) in human
- Adapter protein TKS5 is a scaffolding protein that is required for podosome formation, degradation of the extracellular matrix, and for invasion in some cancer cells
- Three isoforms of TKS5 have been described that are produced by alternative splicing
- TKS5 is a cytoplasmic protein in normal cells, but it localizes to podosomes in SRC-transformed cells
- It is found in several cancer cell lines, particularly invasive breast carcinomas and melanomas
- TKS5 contains one PX (phx homology) domain and five SH3 domains
- The PX domain is required for podosome localization because of its ability to bind phosphoinosiltols, such as PtdIns3P and PtdIns(3,4)P2 and to lesser extent PtdIns5P and PtdIns(3,5)P2
- Its binding with ADAM12, ADAM15 and ADAM19 is mediated by the fifth SH3 domain
- The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region.
Compare Similar Items
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Antigen: This mouse monoclonal TKS5
Classification: Monoclonal
Conjugate: Unconjugated
Gene Alias: Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 9H2.1
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen: GST/His-tagged recombinant fragment corresponding to 91 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity: 25 μg
Research Discipline: Cell Structure
Test Specificity: Clone 9H2.1 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 91 amino acids crom the C-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
This mouse monoclonal TKS5
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Alias:
Adapter protein TKS5;Five SH3 domain-containing protein;SH3 multiple domains protein 1;Tyrosine kinase substrate with five SH3 domains;SH3 and PX domain-containing protein 2A
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
9H2.1
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen:
GST/His-tagged recombinant fragment corresponding to 91 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity:
25 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone 9H2.1 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 91 amino acids crom the C-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: phospho-cytokeratin-8 (K8) (Ser431)
Classification: Monoclonal
Conjugate: Unconjugated
Gene Alias: Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Applications: Immunofluorescence, Western Blot
Clone: 5B3
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: KRT8;CYK8
Immunogen: Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity: 100 μg
Research Discipline: Cell Structure
Test Specificity: Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
phospho-cytokeratin-8 (K8) (Ser431)
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Alias:
Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunofluorescence, Western Blot
Clone:
5B3
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
KRT8;CYK8
Immunogen:
Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity:
100 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: phospho-cytokeratin-8 (K8) (Ser431)
Classification: Monoclonal
Conjugate: Unconjugated
Gene Alias: Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Applications: Immunofluorescence, Western Blot
Clone: 5B3
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: KRT8;CYK8
Immunogen: Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity: 25 μg
Research Discipline: Cell Structure
Test Specificity: Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
phospho-cytokeratin-8 (K8) (Ser431)
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Alias:
Keratin;type II cytoskeletal 8;CK-8;Keratin-8;K8;Type-II keratin Kb80
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunofluorescence, Western Blot
Clone:
5B3
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
KRT8;CYK8
Immunogen:
Cytokeratin-8/18 purified from okadaic acid-treated HT29 cells.
Quantity:
25 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone 5B3 specifically detects cytokeratin-8 phosphorylated on serine 431.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Proteinase 3/PR3
Classification: Monoclonal
Conjugate: Unconjugated
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: ELISA, Flow Cytometry, Western Blot
Clone: MCPR3-2
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: Granule extract from HMC-1/PR3 mast cells expressing transfected human neutrophil PR3 (Sun, J., et al. (1998). J. Immunol. Methods. 211(1-2):111-123).
Quantity: 100 μg
Research Discipline: Cell Structure
Test Specificity: Clone MCPR3-2 detected wild-type PR3 and the catalytically inactive S176A PR3 mutant, but not neutrophil elastase or cathepsin G. Clone MCPR3-2 did not interfere with PR3 enzymatic activity or its interaction with α1-protease inhibitor/α1-PI (Sun, J., et al. (1998). J. Immunol. Methods. 211(1-2):111-123). The ratios of OD readings obtained with PR3-complexed clone MCPR3-2 to the corresponding ODs obtained with PR3-complexed clone MCPR3-3 (Mfr. No. MABF973) in ELISA-based serum PR3 autoantibodies (ANCAs) measurements correlate well with the neutralizing activity of ANCAs in patients serum samples (Silva, F., et al. (2010). J. Autoimmun. 35(4) 299-308).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Proteinase 3/PR3
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
ELISA, Flow Cytometry, Western Blot
Clone:
MCPR3-2
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
Granule extract from HMC-1/PR3 mast cells expressing transfected human neutrophil PR3 (Sun, J., et al. (1998). J. Immunol. Methods. 211(1-2):111-123).
Quantity:
100 μg
Research Discipline:
Cell Structure
Test Specificity:
Clone MCPR3-2 detected wild-type PR3 and the catalytically inactive S176A PR3 mutant, but not neutrophil elastase or cathepsin G. Clone MCPR3-2 did not interfere with PR3 enzymatic activity or its interaction with α1-protease inhibitor/α1-PI (Sun, J., et al. (1998). J. Immunol. Methods. 211(1-2):111-123). The ratios of OD readings obtained with PR3-complexed clone MCPR3-2 to the corresponding ODs obtained with PR3-complexed clone MCPR3-3 (Mfr. No. MABF973) in ELISA-based serum PR3 autoantibodies (ANCAs) measurements correlate well with the neutralizing activity of ANCAs in patients serum samples (Silva, F., et al. (2010). J. Autoimmun. 35(4) 299-308).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ