NBP248103

TTF-1/ NKX2-1 Antibody (8G7G3/1) - IHC-Prediluted, Novus Biologicals™

Manufacturer: Novus Biologicals

Select a Size

Pack Size SKU Availability Price
Each of 1 NBP248103-Each-of-1 In Stock ₹ 44,833.44

NBP248103 - Each of 1

₹ 44,833.44

In Stock

Quantity

1

Base Price: ₹ 44,833.44

GST (18%): ₹ 8,070.019

Total Price: ₹ 52,903.459

Antigen

TTF-1 / NKX2-1

Classification

Monoclonal

Conjugate

Unconjugated

Formulation

10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Gene Symbols

NKX2-1

Immunogen

Rat full length TTF-1/ NKX2-1 recombinant protein (Uniprot: P43699)

Purification Method

Protein A or G purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Content And Storage

Store at 4C.

Isotype

IgG1 κ

Applications

Immunohistochemistry (Paraffin)

Clone

8G7G3/1

Dilution

Immunohistochemistry-Paraffin

Gene Alias

benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2

Host Species

Mouse

Molecular Weight of Antigen

40 kDa

Quantity

7 mL

Research Discipline

Membrane Trafficking and Chaperones, Tumor Biomarkers

Gene ID (Entrez)

7080

Target Species

Human, Mouse, Rat

Form

Purified

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Description

  • TTF-1 / NKX2-1 Monoclonal specifically detects TTF-1 / NKX2-1 in Human, Mouse, Rat samples
  • It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

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Novus Biologicals

NBP248103

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Antigen:
TTF-1 / NKX2-1

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Gene Symbols:
NKX2-1

Immunogen:
Rat full length TTF-1/ NKX2-1 recombinant protein (Uniprot: P43699)

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Content And Storage:
Store at 4C.

Isotype:
IgG1 κ

Applications:
Immunohistochemistry (Paraffin)

Clone:
8G7G3/1

Dilution:
Immunohistochemistry-Paraffin

Gene Alias:
benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2

Host Species:
Mouse

Molecular Weight of Antigen:
40 kDa

Quantity:
7 mL

Research Discipline:
Membrane Trafficking and Chaperones, Tumor Biomarkers

Gene ID (Entrez):
7080

Target Species:
Human, Mouse, Rat

Form:
Purified

Img

Novus Biologicals

NBP248104

--


Antigen:
TTF-1 / NKX2-1

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Gene Symbols:
NKX2-1

Immunogen:
Recombinant TTF-1/ NKX2-1 protein (Uniprot: P43699)

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

Content And Storage:
Store at 4C.

Isotype:
IgG1 κ

Applications:
Immunohistochemistry (Paraffin)

Clone:
NX2.1/690

Dilution:
Immunohistochemistry-Paraffin

Gene Alias:
benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2

Host Species:
Mouse

Molecular Weight of Antigen:
40 kDa

Quantity:
7 mL

Research Discipline:
Membrane Trafficking and Chaperones, Tumor Biomarkers

Gene ID (Entrez):
7080

Target Species:
Human, Mouse, Rat

Form:
Purified

Img

Novus Biologicals

NBP248105

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Antigen:
HLA DR/DP

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Gene Symbols:
HLA-DRA

Immunogen:
Human REH cells

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR and DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36kDa) and a chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

Content And Storage:
Store at 4C.

Isotype:
IgG3 κ

Applications:
Immunohistochemistry (Paraffin)

Clone:
Bra-14

Dilution:
Immunohistochemistry-Paraffin

Gene Alias:
FLJ51114, histocompatibility antigen HLA-DR alpha, HLA class II histocompatibility antigen, DR alpha chain, HLA-DRA1, major histocompatibility complex, class II, DR alpha, MHC cell surface glycoprotein, MHC class II antigen DRA, MLRW

Host Species:
Mouse

Molecular Weight of Antigen:
__

Quantity:
7 mL

Research Discipline:
Adaptive Immunity, Cell Biology, Diabetes Research, Immunology

Gene ID (Entrez):
3122

Target Species:
Human

Form:
Purified

Img

Novus Biologicals

NBP248107

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Antigen:
Complement C4b/d

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Gene Symbols:
C4B

Immunogen:
Recombinant human Complement 4d protein

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
This monoclonal antibody is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.

Content And Storage:
Store at 4C.

Isotype:
IgG1 κ

Applications:
Immunohistochemistry (Paraffin)

Clone:
SPM545

Dilution:
Immunohistochemistry-Paraffin

Gene Alias:
basic C4, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4B1, C4B12, C4B2, C4B3, C4FMGC164979, CH, Chido form of C4, CO4C4B5, complement C4-B, complement C4B1a, complement component 4B, complement component 4B (Chido blood group), CPAMD3FLJ60561, EC 2.1.1.144, EC 2.7.11

Host Species:
Mouse

Molecular Weight of Antigen:
192 kDa

Quantity:
7 mL

Research Discipline:
__

Gene ID (Entrez):
721

Target Species:
Human

Form:
Purified