NBP248160
Androgen R/NR3C4 Antibody (SPM335) - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248160-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP248160 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
Androgen R/NR3C4
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols
AR
Immunogen
A synthetic peptide, aa 302-318 (STEDTAEYSPFKGGYTK) of human Androgen R/NR3C4 (Uniprot: P10275)
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This monoclonal antibody is superb for staining of formalin/paraffin tissues.
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin)
Clone
SPM335
Dilution
Immunohistochemistry-Paraffin
Gene Alias
AIS, androgen receptor, DHTRTFM, Dihydrotestosterone receptorHYSP1, HUMARA, NR3C4KD, Nuclear receptor subfamily 3 group C member 4, SMAX1SBMA, spinal and bulbar muscular atrophy
Host Species
Mouse
Molecular Weight of Antigen
110 kDa
Quantity
7 mL
Research Discipline
Breast Cancer, Cancer, Cellular Markers
Gene ID (Entrez)
367
Target Species
Human, Mouse (Negative)
Form
Purified
Related Products
Description
- Androgen R/NR3C4 Monoclonal specifically detects Androgen R/NR3C4 in Human, Mouse (Negative) samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
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Antigen: Androgen R/NR3C4
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: AR
Immunogen: A synthetic peptide, aa 302-318 (STEDTAEYSPFKGGYTK) of human Androgen R/NR3C4 (Uniprot: P10275)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This monoclonal antibody is superb for staining of formalin/paraffin tissues.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: SPM335
Dilution: Immunohistochemistry-Paraffin
Gene Alias: AIS, androgen receptor, DHTRTFM, Dihydrotestosterone receptorHYSP1, HUMARA, NR3C4KD, Nuclear receptor subfamily 3 group C member 4, SMAX1SBMA, spinal and bulbar muscular atrophy
Host Species: Mouse
Molecular Weight of Antigen: 110 kDa
Quantity: 7 mL
Research Discipline: Breast Cancer, Cancer, Cellular Markers
Gene ID (Entrez): 367
Target Species: Human, Mouse (Negative)
Form: Purified
Antigen:
Androgen R/NR3C4
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
AR
Immunogen:
A synthetic peptide, aa 302-318 (STEDTAEYSPFKGGYTK) of human Androgen R/NR3C4 (Uniprot: P10275)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 110kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin. This monoclonal antibody is superb for staining of formalin/paraffin tissues.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin)
Clone:
SPM335
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
AIS, androgen receptor, DHTRTFM, Dihydrotestosterone receptorHYSP1, HUMARA, NR3C4KD, Nuclear receptor subfamily 3 group C member 4, SMAX1SBMA, spinal and bulbar muscular atrophy
Host Species:
Mouse
Molecular Weight of Antigen:
110 kDa
Quantity:
7 mL
Research Discipline:
Breast Cancer, Cancer, Cellular Markers
Gene ID (Entrez):
367
Target Species:
Human, Mouse (Negative)
Form:
Purified
Antigen: Cytochrome c
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: CYCS
Immunogen: Recombinant full-length human Cytochrome c protein (Uniprot: P99999)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This monoclonal antibody recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Content And Storage: Store at 4C.
Isotype: IgG2b κ
Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone: CYCS/1010
Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias: CYCHCS, cytochrome c, cytochrome c, somatic, THC4
Host Species: Mouse
Molecular Weight of Antigen: 15 kDa
Quantity: 7 mL
Research Discipline: Apoptosis, Cellular Markers, Cholesterol Metabolism, Core ESC Like Genes, Lipid and Metabolism, Mitochondrial Markers, Stem Cell Markers
Gene ID (Entrez): 54205
Target Species: Human, Rat
Form: Purified
Antigen:
Cytochrome c
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
CYCS
Immunogen:
Recombinant full-length human Cytochrome c protein (Uniprot: P99999)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This monoclonal antibody recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Content And Storage:
Store at 4C.
Isotype:
IgG2b κ
Applications:
Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone:
CYCS/1010
Dilution:
Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias:
CYCHCS, cytochrome c, cytochrome c, somatic, THC4
Host Species:
Mouse
Molecular Weight of Antigen:
15 kDa
Quantity:
7 mL
Research Discipline:
Apoptosis, Cellular Markers, Cholesterol Metabolism, Core ESC Like Genes, Lipid and Metabolism, Mitochondrial Markers, Stem Cell Markers
Gene ID (Entrez):
54205
Target Species:
Human, Rat
Form:
Purified
Antigen: Cytochrome c
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: CYCS
Immunogen: Synthetic peptides corresponding to amino acid 1-80, 81-104 and 66-104 of pigeon cytochrome c (7H8.2C12); Recombinant full-length human CYCS protein (CYCS/1010) (Uniprot: P99999)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This monoclonal antibody recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Content And Storage: Store at 4C.
Isotype: IgG2b κ
Applications: Immunohistochemistry (Paraffin)
Clone: 7H8.2C12 + CYCS/1010
Dilution: Immunohistochemistry-Paraffin
Gene Alias: CYCHCS, cytochrome c, cytochrome c, somatic, THC4
Host Species: Mouse
Molecular Weight of Antigen: 15 kDa
Quantity: 7 mL
Research Discipline: Apoptosis, Cellular Markers, Cholesterol Metabolism, Core ESC Like Genes, Lipid and Metabolism, Mitochondrial Markers, Stem Cell Markers
Gene ID (Entrez): 54205
Target Species: Human, Rat
Form: Purified
Antigen:
Cytochrome c
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
CYCS
Immunogen:
Synthetic peptides corresponding to amino acid 1-80, 81-104 and 66-104 of pigeon cytochrome c (7H8.2C12); Recombinant full-length human CYCS protein (CYCS/1010) (Uniprot: P99999)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This monoclonal antibody recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Content And Storage:
Store at 4C.
Isotype:
IgG2b κ
Applications:
Immunohistochemistry (Paraffin)
Clone:
7H8.2C12 + CYCS/1010
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
CYCHCS, cytochrome c, cytochrome c, somatic, THC4
Host Species:
Mouse
Molecular Weight of Antigen:
15 kDa
Quantity:
7 mL
Research Discipline:
Apoptosis, Cellular Markers, Cholesterol Metabolism, Core ESC Like Genes, Lipid and Metabolism, Mitochondrial Markers, Stem Cell Markers
Gene ID (Entrez):
54205
Target Species:
Human, Rat
Form:
Purified
Antigen: MAGE 1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: MAGEA1
Immunogen: Recombinant human MAGE 1 protein (Uniprot: P43355)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 42-46kDa, identified as MAGE-1. This monoclonal antibody does not cross-react with other members of MAGE-family. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: MZ2E/838
Dilution: Immunohistochemistry-Paraffin
Gene Alias: Antigen MZ2-E, Cancer/testis antigen 1.1, cancer/testis antigen family 1, member 1, CT1.1melanoma antigen family A 1, MAGE-1 antigen, MAGE1A, MAGE1melanoma antigen MAGE-1, melanoma antigen family A, 1 (directs expression of antigen MZ2-E), melanoma-associated antigen 1, melanoma-associated antigen MZ2-E, MGC9326
Host Species: Mouse
Molecular Weight of Antigen: __
Quantity: 7 mL
Research Discipline: Apoptosis, Cancer, Melanoma Cell Markers, Tumor Suppressors
Gene ID (Entrez): 4100
Target Species: Human
Form: Purified
Antigen:
MAGE 1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
MAGEA1
Immunogen:
Recombinant human MAGE 1 protein (Uniprot: P43355)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 42-46kDa, identified as MAGE-1. This monoclonal antibody does not cross-react with other members of MAGE-family. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin)
Clone:
MZ2E/838
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
Antigen MZ2-E, Cancer/testis antigen 1.1, cancer/testis antigen family 1, member 1, CT1.1melanoma antigen family A 1, MAGE-1 antigen, MAGE1A, MAGE1melanoma antigen MAGE-1, melanoma antigen family A, 1 (directs expression of antigen MZ2-E), melanoma-associated antigen 1, melanoma-associated antigen MZ2-E, MGC9326
Host Species:
Mouse
Molecular Weight of Antigen:
__
Quantity:
7 mL
Research Discipline:
Apoptosis, Cancer, Melanoma Cell Markers, Tumor Suppressors
Gene ID (Entrez):
4100
Target Species:
Human
Form:
Purified