TFF1/pS2 Antibody (SPM313) - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248460-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP248460 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
TFF1/pS2
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols
TFF1
Immunogen
A synthetic peptide (around aa 57-84) of human TFF1/pS2 polypeptide (exact sequence is proprietary) (Uniprot: P04155)
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin)
Clone
SPM313
Dilution
Immunohistochemistry-Paraffin
Gene Alias
BCEIbreast cancer, estrogen-inducible sequence expressed in, Breast cancer estrogen-inducible protein, breast cancer estrogen-inducible sequence, D21S21, gastrointestinal trefoil protein pS2, hP1.A, HPS2, pNR-2, Polypeptide P1.A, Protein pS2, pS2, trefoil factor 1, trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A
Host Species
Mouse
Molecular Weight of Antigen
6.5 kDa
Quantity
7 mL
Research Discipline
Breast Cancer, Cancer
Gene ID (Entrez)
7031
Target Species
Human, Cynomolgus Monkey
Form
Purified
Related Products
Description
- TFF1/pS2 Monoclonal specifically detects TFF1/pS2 in Human, Cynomolgus Monkey samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
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Antigen: TFF1/pS2
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TFF1
Immunogen: A synthetic peptide (around aa 57-84) of human TFF1/pS2 polypeptide (exact sequence is proprietary) (Uniprot: P04155)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: SPM313
Dilution: Immunohistochemistry-Paraffin
Gene Alias: BCEIbreast cancer, estrogen-inducible sequence expressed in, Breast cancer estrogen-inducible protein, breast cancer estrogen-inducible sequence, D21S21, gastrointestinal trefoil protein pS2, hP1.A, HPS2, pNR-2, Polypeptide P1.A, Protein pS2, pS2, trefoil factor 1, trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A
Host Species: Mouse
Molecular Weight of Antigen: 6.5 kDa
Quantity: 7 mL
Research Discipline: Breast Cancer, Cancer
Gene ID (Entrez): 7031
Target Species: Human, Cynomolgus Monkey
Form: Purified
Antigen: TFF1/pS2
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TFF1
Immunogen: A synthetic peptide from the C-terminus of human TFF1/pS2 protein. (Uniprot: P04155)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: TFF1/1091
Dilution: Immunohistochemistry-Paraffin
Gene Alias: BCEIbreast cancer, estrogen-inducible sequence expressed in, Breast cancer estrogen-inducible protein, breast cancer estrogen-inducible sequence, D21S21, gastrointestinal trefoil protein pS2, hP1.A, HPS2, pNR-2, Polypeptide P1.A, Protein pS2, pS2, trefoil factor 1, trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A
Host Species: Mouse
Molecular Weight of Antigen: 6.5 kDa
Quantity: 7 mL
Research Discipline: Breast Cancer, Cancer
Gene ID (Entrez): 7031
Target Species: Human, Monkey
Form: Purified
Antigen: TGF-alpha
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TGFA
Immunogen: Recombinant human full-length TGF-alpha protein (Uniprot: P01135)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This antibody reacts with the C-terminus of TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. TGF (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: TGFA/1119
Dilution: Immunohistochemistry-Paraffin
Gene Alias: protransforming growth factor alpha, TFGA, transforming growth factor, alpha, transforming growth factor-alpha
Host Species: Mouse
Molecular Weight of Antigen: __
Quantity: 7 mL
Research Discipline: Angiogenesis, Cell Cycle and Replication, Signal Transduction
Gene ID (Entrez): 7039
Target Species: Human
Form: Purified