NBP275731
MTAP Antibody (MTAP/1813) - Azide and BSA Free, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP275731-Each-of-1 | In Stock | ₹ 55,485.66 |
NBP275731 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,485.66
GST (18%): ₹ 9,987.419
Total Price: ₹ 65,473.079
Antigen
MTAP
Classification
Monoclonal
Concentration
0.2 mg/ml
Dilution
Western Blot : 0.5-2 ug/ml, ELISA 2 - 4 ug/mL, Immunohistochemistry 1 - 2 ug/mL, Immunohistochemistry-Paraffin : 1-2 ug/ml, Protein Array
Gene Alias
5'-methylthioadenosine phosphorylase, c86fus, EC 2.4.2.28, methylthioadenosine phosphorylase, MSAPMeSAdo phosphorylase, MTA phosphorylase, MTAPase, S-methyl-5'-thioadenosine phosphorylase
Host Species
Mouse
Molecular Weight of Antigen
31 kDa
Quantity
100 μg
Gene ID (Entrez)
4507.0
Target Species
Human
Form
Purified
Applications
Western Blot, ELISA, Immunohistochemistry (Paraffin)
Clone
MTAP/1813
Conjugate
Unconjugated
Formulation
10 mM PBS with No Preservative
Gene Symbols
MTAP
Immunogen
Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary) (Uniprot: Q13126)
Purification Method
Protein A or G purified
Primary or Secondary
Primary
Test Specificity
Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
Content And Storage
Store at 4°C.
Isotype
IgG2b κ
Description
- MTAP Monoclonal specifically detects MTAP in Human samples
- It is validated for Western Blot, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.
Compare Similar Items
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Antigen: MTAP
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Western Blot : 0.5-2 ug/ml, ELISA 2 - 4 ug/mL, Immunohistochemistry 1 - 2 ug/mL, Immunohistochemistry-Paraffin : 1-2 ug/ml, Protein Array
Gene Alias: 5'-methylthioadenosine phosphorylase, c86fus, EC 2.4.2.28, methylthioadenosine phosphorylase, MSAPMeSAdo phosphorylase, MTA phosphorylase, MTAPase, S-methyl-5'-thioadenosine phosphorylase
Host Species: Mouse
Molecular Weight of Antigen: 31 kDa
Quantity: 100 μg
Gene ID (Entrez): 4507.0
Target Species: Human
Form: Purified
Applications: Western Blot, ELISA, Immunohistochemistry (Paraffin)
Clone: MTAP/1813
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Symbols: MTAP
Immunogen: Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary) (Uniprot: Q13126)
Purification Method: Protein A or G purified
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
MTAP
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Western Blot : 0.5-2 ug/ml, ELISA 2 - 4 ug/mL, Immunohistochemistry 1 - 2 ug/mL, Immunohistochemistry-Paraffin : 1-2 ug/ml, Protein Array
Gene Alias:
5'-methylthioadenosine phosphorylase, c86fus, EC 2.4.2.28, methylthioadenosine phosphorylase, MSAPMeSAdo phosphorylase, MTA phosphorylase, MTAPase, S-methyl-5'-thioadenosine phosphorylase
Host Species:
Mouse
Molecular Weight of Antigen:
31 kDa
Quantity:
100 μg
Gene ID (Entrez):
4507.0
Target Species:
Human
Form:
Purified
Applications:
Western Blot, ELISA, Immunohistochemistry (Paraffin)
Clone:
MTAP/1813
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Symbols:
MTAP
Immunogen:
Recombinant human MTAP protein fragment (aa97-196) (exact sequence is proprietary) (Uniprot: Q13126)
Purification Method:
Protein A or G purified
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ
Antigen: OCT2
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Alias: homeobox protein, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, OCT2Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, OTF2POU domain class 2, transcription factor 2, POU class 2 homeobox 2, POU domain, class 2, transcription factor 2
Host Species: Mouse
Molecular Weight of Antigen: 60 kDa
Quantity: 100 μg
Gene ID (Entrez): 5452.0
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: OCT2/2136
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Symbols: POU2F2
Immunogen: Recombinant fragment of human OCT2 protein (around aa 112-297) (exact sequence is proprietary) (Uniprot: P09086)
Purification Method: Protein A or G purified
Primary or Secondary: Primary
Test Specificity: OCT2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. OCT2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of OCT2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of OCT2. Several studies of OCT2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for OCT2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.
Content And Storage: Store at 4°C.
Isotype: IgG1 κ
Antigen:
OCT2
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Alias:
homeobox protein, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, OCT2Oct-2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, OTF2POU domain class 2, transcription factor 2, POU class 2 homeobox 2, POU domain, class 2, transcription factor 2
Host Species:
Mouse
Molecular Weight of Antigen:
60 kDa
Quantity:
100 μg
Gene ID (Entrez):
5452.0
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
OCT2/2136
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Symbols:
POU2F2
Immunogen:
Recombinant fragment of human OCT2 protein (around aa 112-297) (exact sequence is proprietary) (Uniprot: P09086)
Purification Method:
Protein A or G purified
Primary or Secondary:
Primary
Test Specificity:
OCT2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. OCT2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of OCT2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of OCT2. Several studies of OCT2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for OCT2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.
Content And Storage:
Store at 4°C.
Isotype:
IgG1 κ
Antigen: Perforin
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Alias: Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin
Host Species: Mouse
Molecular Weight of Antigen: 75 kDa
Quantity: 100 μg
Gene ID (Entrez): 5551.0
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: PRF1/2468
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Symbols: PRF1
Immunogen: Recombinant human Perforin protein fragment (around aa 413-552) (exact sequence is proprietary) (Uniprot: P14222)
Purification Method: Protein A or G purified
Primary or Secondary: Primary
Test Specificity: Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
Perforin
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Alias:
Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin
Host Species:
Mouse
Molecular Weight of Antigen:
75 kDa
Quantity:
100 μg
Gene ID (Entrez):
5551.0
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
PRF1/2468
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Symbols:
PRF1
Immunogen:
Recombinant human Perforin protein fragment (around aa 413-552) (exact sequence is proprietary) (Uniprot: P14222)
Purification Method:
Protein A or G purified
Primary or Secondary:
Primary
Test Specificity:
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ
Antigen: StAR
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Alias: cholesterol trafficker, mitochondrial steroid acute regulatory protein, StAR, StARD1, STARD1StAR-related lipid transfer (START) domain containing 1, START domain containing 1, START domain-containing protein 1, steroid acute regulatory protein, steroidogenic acute regulator, steroidogenic acute regulatory protein, steroidogenic acute regulatory protein, mitochondrial
Host Species: Mouse
Molecular Weight of Antigen: 30 kDa
Quantity: 100 μg
Gene ID (Entrez): 6770.0
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: STAR/2140
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Symbols: STAR
Immunogen: Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Purification Method: Protein A or G purified
Primary or Secondary: Primary
Test Specificity: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
StAR
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Alias:
cholesterol trafficker, mitochondrial steroid acute regulatory protein, StAR, StARD1, STARD1StAR-related lipid transfer (START) domain containing 1, START domain containing 1, START domain-containing protein 1, steroid acute regulatory protein, steroidogenic acute regulator, steroidogenic acute regulatory protein, steroidogenic acute regulatory protein, mitochondrial
Host Species:
Mouse
Molecular Weight of Antigen:
30 kDa
Quantity:
100 μg
Gene ID (Entrez):
6770.0
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
STAR/2140
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Symbols:
STAR
Immunogen:
Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Purification Method:
Protein A or G purified
Primary or Secondary:
Primary
Test Specificity:
Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ