NBP275737
Perforin Antibody (PRF1/2468) - Azide and BSA Free, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP275737-Each-of-1 | In Stock | ₹ 60,490.92 |
NBP275737 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 60,490.92
GST (18%): ₹ 10,888.366
Total Price: ₹ 71,379.286
Antigen
Perforin
Classification
Monoclonal
Concentration
0.2 mg/ml
Dilution
Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.
P14222
Gene Symbols
PRF1
Immunogen
Recombinant human Perforin protein fragment (around aa 413-552) (exact sequence is proprietary) (Uniprot: P14222)
Purification Method
Protein A or G purified
Research Discipline
Adaptive Immunity, Apoptosis, Immunology, Innate Immunity
Gene ID (Entrez)
5551.0
Target Species
Human
Form
Purified
Applications
Immunohistochemistry (Paraffin)
Clone
PRF1/2468
Conjugate
Unconjugated
Formulation
10 mM PBS with No Preservative
Gene Alias
Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin
Host Species
Mouse
Molecular Weight of Antigen
75 kDa
Quantity
100 μg
Primary or Secondary
Primary
Test Specificity
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Content And Storage
Store at 4°C.
Isotype
IgG2b κ
Related Products
Description
- Perforin Monoclonal specifically detects Perforin in Human samples
- It is validated for ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array.
Compare Similar Items
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Antigen: Perforin
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.: P14222
Gene Symbols: PRF1
Immunogen: Recombinant human Perforin protein fragment (around aa 413-552) (exact sequence is proprietary) (Uniprot: P14222)
Purification Method: Protein A or G purified
Research Discipline: Adaptive Immunity, Apoptosis, Immunology, Innate Immunity
Gene ID (Entrez): 5551.0
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: PRF1/2468
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Alias: Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin
Host Species: Mouse
Molecular Weight of Antigen: 75 kDa
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
Perforin
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.:
P14222
Gene Symbols:
PRF1
Immunogen:
Recombinant human Perforin protein fragment (around aa 413-552) (exact sequence is proprietary) (Uniprot: P14222)
Purification Method:
Protein A or G purified
Research Discipline:
Adaptive Immunity, Apoptosis, Immunology, Innate Immunity
Gene ID (Entrez):
5551.0
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
PRF1/2468
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Alias:
Cytolysin, FLH2, HPLH2, HPLH2lymphocyte pore forming protein, Lymphocyte pore-forming protein, MGC65093, P1PFN1, perforin 1 (pore forming protein), perforin-1, PFPcytolysin
Host Species:
Mouse
Molecular Weight of Antigen:
75 kDa
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ
Antigen: StAR
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.: __
Gene Symbols: STAR
Immunogen: Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Purification Method: Protein A or G purified
Research Discipline: Cancer
Gene ID (Entrez): 6770.0
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: STAR/2140
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Alias: cholesterol trafficker, mitochondrial steroid acute regulatory protein, StAR, StARD1, STARD1StAR-related lipid transfer (START) domain containing 1, START domain containing 1, START domain-containing protein 1, steroid acute regulatory protein, steroidogenic acute regulator, steroidogenic acute regulatory protein, steroidogenic acute regulatory protein, mitochondrial
Host Species: Mouse
Molecular Weight of Antigen: 30 kDa
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
StAR
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.:
__
Gene Symbols:
STAR
Immunogen:
Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Purification Method:
Protein A or G purified
Research Discipline:
Cancer
Gene ID (Entrez):
6770.0
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
STAR/2140
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Alias:
cholesterol trafficker, mitochondrial steroid acute regulatory protein, StAR, StARD1, STARD1StAR-related lipid transfer (START) domain containing 1, START domain containing 1, START domain-containing protein 1, steroid acute regulatory protein, steroidogenic acute regulator, steroidogenic acute regulatory protein, steroidogenic acute regulatory protein, mitochondrial
Host Species:
Mouse
Molecular Weight of Antigen:
30 kDa
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ
Antigen: StAR
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.: __
Gene Symbols: STAR
Immunogen: Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Purification Method: Protein A or G purified
Research Discipline: Cancer
Gene ID (Entrez): 6770.0
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: STAR/2154
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Alias: cholesterol trafficker, mitochondrial steroid acute regulatory protein, StAR, StARD1, STARD1StAR-related lipid transfer (START) domain containing 1, START domain containing 1, START domain-containing protein 1, steroid acute regulatory protein, steroidogenic acute regulator, steroidogenic acute regulatory protein, steroidogenic acute regulatory protein, mitochondrial
Host Species: Mouse
Molecular Weight of Antigen: 30 kDa
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Content And Storage: Store at 4°C.
Isotype: IgG1 κ
Antigen:
StAR
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.:
__
Gene Symbols:
STAR
Immunogen:
Recombinant fragment (around aa 39-108) of human StAR protein (exact sequence is proprietary) (Uniprot: P49675)
Purification Method:
Protein A or G purified
Research Discipline:
Cancer
Gene ID (Entrez):
6770.0
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
STAR/2154
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Alias:
cholesterol trafficker, mitochondrial steroid acute regulatory protein, StAR, StARD1, STARD1StAR-related lipid transfer (START) domain containing 1, START domain containing 1, START domain-containing protein 1, steroid acute regulatory protein, steroidogenic acute regulator, steroidogenic acute regulatory protein, steroidogenic acute regulatory protein, mitochondrial
Host Species:
Mouse
Molecular Weight of Antigen:
30 kDa
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.
Content And Storage:
Store at 4°C.
Isotype:
IgG1 κ
Antigen: TROP-2
Classification: Monoclonal
Concentration: 0.2 mg/ml
Dilution: Western Blot 0.5-1 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.: P09758
Gene Symbols: TACSTD2
Immunogen: Recombinant fragment of human TROP-2 protein (around aa 31-274) (exact sequence is proprietary) (Uniprot: P09758 )
Purification Method: Protein A or G purified
Research Discipline: Signal Transduction
Gene ID (Entrez): 4070.0
Target Species: Human
Form: Purified
Applications: Western Blot, Immunohistochemistry (Paraffin)
Clone: TACSTD2/2151
Conjugate: Unconjugated
Formulation: 10 mM PBS with No Preservative
Gene Alias: Cell surface glycoprotein Trop-2, EGP1, EGP-1, epithelial glycoprotein-1, GA733-1GP50, gastrointestinal tumor-associated antigen GA7331, M1S1cell surface glycoprotein TROP2, Membrane component chromosome 1 surface marker 1, membrane component, chromosome 1, surface marker 1, Pancreatic carcinoma marker protein GA733-1, pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733, TROP2GA7331, tumor-associated calcium signal transducer 2
Host Species: Mouse
Molecular Weight of Antigen: 40 kDa
Quantity: 100 μg
Primary or Secondary: Primary
Test Specificity: TROP-2 is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thyroglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. It plays a role in transducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells.
Content And Storage: Store at 4°C.
Isotype: IgG2b κ
Antigen:
TROP-2
Classification:
Monoclonal
Concentration:
0.2 mg/ml
Dilution:
Western Blot 0.5-1 ug/ml, Immunohistochemistry-Paraffin 1-2 ug/ml
Gene Accession No.:
P09758
Gene Symbols:
TACSTD2
Immunogen:
Recombinant fragment of human TROP-2 protein (around aa 31-274) (exact sequence is proprietary) (Uniprot: P09758 )
Purification Method:
Protein A or G purified
Research Discipline:
Signal Transduction
Gene ID (Entrez):
4070.0
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Clone:
TACSTD2/2151
Conjugate:
Unconjugated
Formulation:
10 mM PBS with No Preservative
Gene Alias:
Cell surface glycoprotein Trop-2, EGP1, EGP-1, epithelial glycoprotein-1, GA733-1GP50, gastrointestinal tumor-associated antigen GA7331, M1S1cell surface glycoprotein TROP2, Membrane component chromosome 1 surface marker 1, membrane component, chromosome 1, surface marker 1, Pancreatic carcinoma marker protein GA733-1, pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733, TROP2GA7331, tumor-associated calcium signal transducer 2
Host Species:
Mouse
Molecular Weight of Antigen:
40 kDa
Quantity:
100 μg
Primary or Secondary:
Primary
Test Specificity:
TROP-2 is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thyroglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. It plays a role in transducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells.
Content And Storage:
Store at 4°C.
Isotype:
IgG2b κ