OP134100UG
MilliporeSigma™ anti-IKKbeta Clone: 10AG2,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | OP134100UG-Each-of-1 | In Stock | ₹ 51,421.56 |
OP134100UG - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,421.56
GST (18%): ₹ 9,255.881
Total Price: ₹ 60,677.441
Antigen
IKKβ
Classification
Monoclonal
Conjugate
Unconjugated
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunoblot
Clone
10AG2
Formulation
In PBS, 0.2% gelatin, pH 7.4.
Immunogen
a recombinant protein consisting of full-length human IKKβ fused to a His·Tag™ sequence
Regulatory Status
RUO
Test Specificity
Recognizes the ∽87kDa IKKβ protein in Daudi cells.
Content And Storage
2°C to 8°C
Isotype
IgG1
Related Products
Description
- Specifically detects IKKβ Clone: 10AG2 in Human samples, and it is validated for Immuno Blotting NF-κB (nuclear factor κB) is sequestered in the cytoplasm by IκB family of inhibitory proteins that mask the nuclear localization signal of NF-κB thereby preventing translocation of NF-κB to the nucleus
- External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IκB releasing NF-κB dimers
- NF-κB dimer subsequently translocates to the nucleus and activates target genes
- Synthesis of IκBα is autoregulated
- IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ
- IKK1/α and IKK2/β are phosphorylated by NF-κB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively
- Recent studies have shown that IKK2/β not IKK1/α, is the target proinflammatory stimuli
- Targeted disruption of IKK2/β gene in mice also results in extensive liver damage from apotopsis and death as embryo.
Compare Similar Items
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Antigen: IKKβ
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunoblot
Clone: 10AG2
Formulation: In PBS, 0.2% gelatin, pH 7.4.
Immunogen: a recombinant protein consisting of full-length human IKKβ fused to a His·Tag™ sequence
Regulatory Status: RUO
Test Specificity: Recognizes the ∽87kDa IKKβ protein in Daudi cells.
Content And Storage: 2°C to 8°C
Isotype: IgG1
Antigen:
IKKβ
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunoblot
Clone:
10AG2
Formulation:
In PBS, 0.2% gelatin, pH 7.4.
Immunogen:
a recombinant protein consisting of full-length human IKKβ fused to a His·Tag™ sequence
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽87kDa IKKβ protein in Daudi cells.
Content And Storage:
2°C to 8°C
Isotype:
IgG1
Antigen: c-ErbB2/c-Neu
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Applications: Immunohistochemistry (Paraffin)
Clone: 9G6
Formulation: In 50mM sodium phosphate buffer, 0.2% gelatin, ≤0.1% Sodium Azide.
Immunogen: cells overexpressing human c-ErbB2/c-Neu
Regulatory Status: RUO
Test Specificity: __
Content And Storage: 2°-8°C
Isotype: IgG1
Antigen:
c-ErbB2/c-Neu
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin)
Clone:
9G6
Formulation:
In 50mM sodium phosphate buffer, 0.2% gelatin, ≤0.1% Sodium Azide.
Immunogen:
cells overexpressing human c-ErbB2/c-Neu
Regulatory Status:
RUO
Test Specificity:
__
Content And Storage:
2°-8°C
Isotype:
IgG1
Antigen: MDM2
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Clone: 4B11
Formulation: In 50mM sodium phosphate buffer, 50% glycerol.
Immunogen: full-length, recombinant human MDM2
Regulatory Status: RUO
Test Specificity: Recognizes the ∽90kDa (apparent MW) MDM2 protein in A549 cells. May also recognize the ∽60kDa and ∽90kDa isoforms of MDM2.
Content And Storage: −20°C
Isotype: IgG2a
Antigen:
MDM2
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Clone:
4B11
Formulation:
In 50mM sodium phosphate buffer, 50% glycerol.
Immunogen:
full-length, recombinant human MDM2
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽90kDa (apparent MW) MDM2 protein in A549 cells. May also recognize the ∽60kDa and ∽90kDa isoforms of MDM2.
Content And Storage:
−20°C
Isotype:
IgG2a
Antigen: MDM2
Classification: Monoclonal
Conjugate: Unconjugated
Host Species: Mouse
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Clone: 4B2C1.11
Formulation: In 50mM sodium phosphate buffer, 50% glycerol, pH 7.5.
Immunogen: recombinant, human MDM2
Regulatory Status: RUO
Test Specificity: Recognizes the ∽90kDa (apparent MW) MDM2 protein in A549 and MCF-7 cells and breast carcinoma tissue.
Content And Storage: −20°C
Isotype: IgG1
Antigen:
MDM2
Classification:
Monoclonal
Conjugate:
Unconjugated
Host Species:
Mouse
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Clone:
4B2C1.11
Formulation:
In 50mM sodium phosphate buffer, 50% glycerol, pH 7.5.
Immunogen:
recombinant, human MDM2
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽90kDa (apparent MW) MDM2 protein in A549 and MCF-7 cells and breast carcinoma tissue.
Content And Storage:
−20°C
Isotype:
IgG1