PA14648
Amyloid Precursor Protein Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA14648-Each-of-1 | In Stock | ₹ 50,480.40 |
PA14648 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,480.40
GST (18%): ₹ 9,086.472
Total Price: ₹ 59,566.872
Antigen
Amyloid Precursor Protein
Classification
Polyclonal
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
P05067, P08592, P12023
Gene Symbols
APP
Immunogen
Synthetic peptide corresponding to the C-terminal region of rat APP conjugated to KLH
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Gene
APP
Gene Alias
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid β; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; be
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11820, 351, 54226
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- This antibody is predicted to react with canine, chicken, human, mouse and non-human primate based on 100% sequence homology
- This antibody is specific for ∽115 kDa APP protein
- Immunolabeling of the APP protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen
- Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease
- Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process
- The first step involves cleavage of the extracellular, amino-terminal domain of beta APP
- Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin
- Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant
- The remnant protein is processed by another protease, gamma-secretase
- Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide
- Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components
- The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide
- Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles
- Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain
- Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.
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Antigen: Amyloid Precursor Protein
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: P05067, P08592, P12023
Gene Symbols: APP
Immunogen: Synthetic peptide corresponding to the C-terminal region of rat APP conjugated to KLH
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Gene: APP
Gene Alias: A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid β; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; be
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 11820, 351, 54226
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Amyloid Precursor Protein
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
P05067, P08592, P12023
Gene Symbols:
APP
Immunogen:
Synthetic peptide corresponding to the C-terminal region of rat APP conjugated to KLH
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Gene:
APP
Gene Alias:
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid β; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; be
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
11820, 351, 54226
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Connexin 43
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: P08050
Gene Symbols: GJA1
Immunogen: Synthetic peptide corresponding to the C-terminal region of rat GJA1 conjugated to KLH
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Conjugate: Unconjugated
Gene: GJA1
Gene Alias: alpha 1 connexin; AU042049; AVSD3; AW546267; CMDR; Cnx43; connexin 43; connexin43; connexin-43; cx43; Cx-43; cx43 protein; cx43a1; Cx43alpha1; CXA1; Cxn-43; DFNB38; EKVP; etID309742.9; gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein; gap junction protein alpha 1; gap junction protein connexin 43; gap junction protein, alpha 1; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; gap junction protein, alpha 1, 43kDa (connexin 43); gja1; Gja-1; GJAL; HLHS1; HSS; Npm1; ODD; ODDD; ODOD; PPKCA; SDTY3; shf; Short fin protein; sof; stopsel; stp; Syndactyly type III; vascular smooth muscle connexin43; Vascular smooth muscle connexin-43; zfCx43.3
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 24392
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Connexin 43
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
P08050
Gene Symbols:
GJA1
Immunogen:
Synthetic peptide corresponding to the C-terminal region of rat GJA1 conjugated to KLH
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Conjugate:
Unconjugated
Gene:
GJA1
Gene Alias:
alpha 1 connexin; AU042049; AVSD3; AW546267; CMDR; Cnx43; connexin 43; connexin43; connexin-43; cx43; Cx-43; cx43 protein; cx43a1; Cx43alpha1; CXA1; Cxn-43; DFNB38; EKVP; etID309742.9; gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein; gap junction protein alpha 1; gap junction protein connexin 43; gap junction protein, alpha 1; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; gap junction protein, alpha 1, 43kDa (connexin 43); gja1; Gja-1; GJAL; HLHS1; HSS; Npm1; ODD; ODDD; ODOD; PPKCA; SDTY3; shf; Short fin protein; sof; stopsel; stp; Syndactyly type III; vascular smooth muscle connexin43; Vascular smooth muscle connexin-43; zfCx43.3
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
24392
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: DARPP-32
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: Q60829, Q6J4I0
Gene Symbols: Ppp1r1b
Immunogen: Synthetic peptide corresponding to the N-terminal region of rat PPP1R1B conjugated to KLH
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Conjugate: Unconjugated
Gene: Ppp1r1b
Gene Alias: AU040756; DARPP32; DARPP-32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine and cAMP-regulated neuronal phosphoprotein 32; dopamine- and cAMP-regulated phosphoprotein DARPP-32; FLJ20940; IPPD; neuronal phosphoprotein DARPP-32; OTTHUMP00000164275; OTTHUMP00000164276; Ppp1r1b; PPR1B; protein pho; protein phosphatase 1 regulatory inhibitor subunit 1B; protein phosphatase 1 regulatory subunit 1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 19049, 360616
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
DARPP-32
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
Q60829, Q6J4I0
Gene Symbols:
Ppp1r1b
Immunogen:
Synthetic peptide corresponding to the N-terminal region of rat PPP1R1B conjugated to KLH
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Conjugate:
Unconjugated
Gene:
Ppp1r1b
Gene Alias:
AU040756; DARPP32; DARPP-32; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine and cAMP-regulated neuronal phosphoprotein 32; dopamine- and cAMP-regulated phosphoprotein DARPP-32; FLJ20940; IPPD; neuronal phosphoprotein DARPP-32; OTTHUMP00000164275; OTTHUMP00000164276; Ppp1r1b; PPR1B; protein pho; protein phosphatase 1 regulatory inhibitor subunit 1B; protein phosphatase 1 regulatory subunit 1B; protein phosphatase 1, regulatory (inhibitor) subunit 1B
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
19049, 360616
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: DOPA Decarboxylase
Classification: Polyclonal
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.: P14173, P20711, P22781, P27718
Gene Symbols: DDC
Immunogen: Synthetic peptide corresponding to the N-terminal region of human DDC conjugated to KLH
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Canine, Guinea Pig, Human, Ovine, Rabbit, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Conjugate: Unconjugated
Gene: DDC
Gene Alias: AADC; aromatic L-amino acid decarboxylase; aromatic-L-amino acid decarboxylase; aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); HGNC:2719; L-Dopa decarboxylase
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 100135516, 100355492, 101106765, 1644, 24311, 280762, 606852
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
DOPA Decarboxylase
Classification:
Polyclonal
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Gene Accession No.:
P14173, P20711, P22781, P27718
Gene Symbols:
DDC
Immunogen:
Synthetic peptide corresponding to the N-terminal region of human DDC conjugated to KLH
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Canine, Guinea Pig, Human, Ovine, Rabbit, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Conjugate:
Unconjugated
Gene:
DDC
Gene Alias:
AADC; aromatic L-amino acid decarboxylase; aromatic-L-amino acid decarboxylase; aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); HGNC:2719; L-Dopa decarboxylase
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
100135516, 100355492, 101106765, 1644, 24311, 280762, 606852
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid