PIMA515145
Phospho-CHK1 (Ser345) Monoclonal Antibody (S.48.4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515145-Each-of-1 | In Stock | ₹ 53,303.88 |
PIMA515145 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,303.88
GST (18%): ₹ 9,594.698
Total Price: ₹ 62,898.578
Antigen
Phospho-CHK1 (Ser345)
Classification
Monoclonal
Concentration
37 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
O14757, O35280, Q91ZN7
Gene Symbols
Chek1
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pSer345 of human Chk1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Clone
S.48.4
Conjugate
Unconjugated
Gene
Chek1
Gene Alias
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1111, 12649, 140583
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
- CHK1 is a key mediator in the DNA damage-induced checkpoint network
- CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
- When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
- Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
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Antigen: Phospho-CHK1 (Ser345)
Classification: Monoclonal
Concentration: 37 μg/mL
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: O14757, O35280, Q91ZN7
Gene Symbols: Chek1
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pSer345 of human Chk1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Western Blot
Clone: S.48.4
Conjugate: Unconjugated
Gene: Chek1
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1111, 12649, 140583
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-CHK1 (Ser345)
Classification:
Monoclonal
Concentration:
37 μg/mL
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
O14757, O35280, Q91ZN7
Gene Symbols:
Chek1
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding pSer345 of human Chk1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
S.48.4
Conjugate:
Unconjugated
Gene:
Chek1
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1111, 12649, 140583
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phospho-Cdc25C (Ser216)
Classification: Monoclonal
Concentration: 170 μg/mL
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: P30307
Gene Symbols: Cdc25c
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pSer216 of human cdc25C
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Non-human Primate
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: K.827.0
Conjugate: Unconjugated
Gene: Cdc25c
Gene Alias: CDC25; CDC25C; Cdc25m1; cell division cycle 25C; dual specificity phosphatase CDC25C; EC 3.1.3.48; mitosis inducer CDC25; M-phase inducer phosphatase 3; MPIP3; OTTHUMP00000159490; OTTHUMP00000224012; OTTHUMP00000224013; OTTHUMP00000224016; phosphotyrosine phosphatase; PPP1R60; protein phosphatase 1, regulatory subunit 60
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 995
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-Cdc25C (Ser216)
Classification:
Monoclonal
Concentration:
170 μg/mL
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
P30307
Gene Symbols:
Cdc25c
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding pSer216 of human cdc25C
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Non-human Primate
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
K.827.0
Conjugate:
Unconjugated
Gene:
Cdc25c
Gene Alias:
CDC25; CDC25C; Cdc25m1; cell division cycle 25C; dual specificity phosphatase CDC25C; EC 3.1.3.48; mitosis inducer CDC25; M-phase inducer phosphatase 3; MPIP3; OTTHUMP00000159490; OTTHUMP00000224012; OTTHUMP00000224013; OTTHUMP00000224016; phosphotyrosine phosphatase; PPP1R60; protein phosphatase 1, regulatory subunit 60
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
995
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phospho-VEGF Receptor 2 (Tyr951)
Classification: Monoclonal
Concentration: __
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: P35918, P35968
Gene Symbols: KDR
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pTyr951 of human VEGF receptor 2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: H.266.3
Conjugate: Unconjugated
Gene: KDR
Gene Alias: 6130401C07; CD309; CD309 antigen; fetal liver kinase 1; fetal liver kinase-1; FLK1; Flk-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); flk-1 type VEGF receptor; KDR; kinase insert domain protein receptor; kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); kinase NYK; Krd-1; Ly73; protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; sVEGFR-2; tyrosine kinase growth factor receptor; vascular endotheial growth factor 2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR; VEGFR2; VEGFR-2
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16542, 3791
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-VEGF Receptor 2 (Tyr951)
Classification:
Monoclonal
Concentration:
__
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
P35918, P35968
Gene Symbols:
KDR
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding pTyr951 of human VEGF receptor 2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
H.266.3
Conjugate:
Unconjugated
Gene:
KDR
Gene Alias:
6130401C07; CD309; CD309 antigen; fetal liver kinase 1; fetal liver kinase-1; FLK1; Flk-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); flk-1 type VEGF receptor; KDR; kinase insert domain protein receptor; kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); kinase NYK; Krd-1; Ly73; protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; sVEGFR-2; tyrosine kinase growth factor receptor; vascular endotheial growth factor 2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR; VEGFR2; VEGFR-2
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16542, 3791
Content And Storage:
-20°C
Form:
Liquid
Antigen: IKK gamma
Classification: Monoclonal
Concentration: 2.7 mg/mL
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: Q6TMG5, Q9Y6K9
Gene Symbols: Ikbkg
Immunogen: Full length human GST-IKK gamma protein.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Western Blot
Clone: H.256.9
Conjugate: Unconjugated
Gene: Ikbkg
Gene Alias: 1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP3; FIP-3; Fip3p; gikk; I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; ikB kinase-associated protein 1; IKBKG; IKK[g]; IKK3; IKKAP1; IKKG; IKK-gamma; IMD33; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; mF; mFIP-3; Nemo; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTHUMP00000207079; OTTHUMP00000212188; ZC2HC9
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 309295, 8517
Content And Storage: -20°C
Form: Liquid
Antigen:
IKK gamma
Classification:
Monoclonal
Concentration:
2.7 mg/mL
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
Q6TMG5, Q9Y6K9
Gene Symbols:
Ikbkg
Immunogen:
Full length human GST-IKK gamma protein.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Western Blot
Clone:
H.256.9
Conjugate:
Unconjugated
Gene:
Ikbkg
Gene Alias:
1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP3; FIP-3; Fip3p; gikk; I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; ikB kinase-associated protein 1; IKBKG; IKK[g]; IKK3; IKKAP1; IKKG; IKK-gamma; IMD33; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; mF; mFIP-3; Nemo; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTHUMP00000207079; OTTHUMP00000212188; ZC2HC9
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
309295, 8517
Content And Storage:
-20°C
Form:
Liquid