PIMA515185
Phospho-ATM (Ser1981) Monoclonal Antibody (C.70.6), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515185-Each-of-1 | In Stock | ₹ 50,352.06 |
PIMA515185 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,352.06
GST (18%): ₹ 9,063.371
Total Price: ₹ 59,415.431
Antigen
Phospho-ATM (Ser1981)
Classification
Monoclonal
Concentration
2028 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
Q13315
Gene Symbols
ATM
Immunogen
Synthetic phosphopeptide corresponding to residues around pSer1981 of human ATM
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ChIP Assay, Immunocytochemistry, Western Blot
Clone
C.70.6
Conjugate
Unconjugated
Gene
ATM
Gene Alias
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
472
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody was orginally validated as part of a Thermo Scientific Cellomics High Content Screening Kit
- The antibody sold separately may have slightly different performance and may need to be further optimized for the best results
- Ataxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family
- Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer
- The ATM gene codes for a protein belonging to the phosphoinositide 3-kinase (PI3K) superfamily
- ATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1
- The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens
- The ATM’s C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases)
- Studies have shown that ATM becomes autophosphorylated and upregulated by exposure to ionizing radiation
- AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction
- Further, DNA damage caused by ionizing irradiation activates ATM-kinase, leading to a cascade of kinase reactions that regulate cell cycle, apoptosis, and DNA damage repair
- Studies have linked ATM to apoptosis along with Nbs1 and Chk2 in the E2F1 pathway.
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Antigen: Phospho-ATM (Ser1981)
Classification: Monoclonal
Concentration: 2028 μg/mL
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: Q13315
Gene Symbols: ATM
Immunogen: Synthetic phosphopeptide corresponding to residues around pSer1981 of human ATM
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ChIP Assay, Immunocytochemistry, Western Blot
Clone: C.70.6
Conjugate: Unconjugated
Gene: ATM
Gene Alias: AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 472
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-ATM (Ser1981)
Classification:
Monoclonal
Concentration:
2028 μg/mL
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
Q13315
Gene Symbols:
ATM
Immunogen:
Synthetic phosphopeptide corresponding to residues around pSer1981 of human ATM
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ChIP Assay, Immunocytochemistry, Western Blot
Clone:
C.70.6
Conjugate:
Unconjugated
Gene:
ATM
Gene Alias:
AI256621; AT mutated; A-T mutated; A-T mutated homolog; AT mutated protein; AT1; ATA; Ataxia t; Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; Atm; ATM (phospho S1981); ATM (pS1981); ATM (pSer1981); ATM phospho S1981; ATM phospho Ser1981; ATM serine/threonine kinase; C030026E19Rik; DKFZp781A0353; EC 2.7.1.37; MGC74674; phospho ATM; phospho S1981 ATM; serine-protein kinase ATM; TEL1; TEL1, telomere maintenance 1, homolog; TELO1
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
472
Content And Storage:
-20°C
Form:
Liquid
Antigen: IkB alpha
Classification: Monoclonal
Concentration: 871.7 μg/mL
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: P25963, Q63746, Q9Z1E3
Gene Symbols: NFKBIA
Immunogen: Synthetic peptide corresponding to residues near the carboxy-terminus of human IkB alpha
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Hamster, Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG2a
Applications: Immunoprecipitation, Western Blot
Clone: F.4.4
Conjugate: Unconjugated
Gene: NFKBIA
Gene Alias: AI462015; ECI-6; ECI-6/IKBA; I kappa B-alpha; I(Kappa)B(alpha); I79_018146; IkappaB alpha; IkappaBalpha; I-kappaBalpha; I-kappa-B-alpha; Ikba; IKBalpha; IKB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappaB inhibitor alpha; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Rel-associated pp40; REL-associated protein pp40; RL/IF-1
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 100754153, 18035, 25493, 4792
Content And Storage: -20°C
Form: Liquid
Antigen:
IkB alpha
Classification:
Monoclonal
Concentration:
871.7 μg/mL
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
P25963, Q63746, Q9Z1E3
Gene Symbols:
NFKBIA
Immunogen:
Synthetic peptide corresponding to residues near the carboxy-terminus of human IkB alpha
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Hamster, Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunoprecipitation, Western Blot
Clone:
F.4.4
Conjugate:
Unconjugated
Gene:
NFKBIA
Gene Alias:
AI462015; ECI-6; ECI-6/IKBA; I kappa B-alpha; I(Kappa)B(alpha); I79_018146; IkappaB alpha; IkappaBalpha; I-kappaBalpha; I-kappa-B-alpha; Ikba; IKBalpha; IKB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappaB inhibitor alpha; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Rel-associated pp40; REL-associated protein pp40; RL/IF-1
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
100754153, 18035, 25493, 4792
Content And Storage:
-20°C
Form:
Liquid
Antigen: c-Met
Classification: Monoclonal
Concentration: 1000 μg/mL
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: P08581, P16056, P97523
Gene Symbols: MET
Immunogen: Synthetic peptide corresponding to residues surrounding Tyr1234 of human Met
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunoprecipitation, Western Blot
Clone: K.845.5
Conjugate: Unconjugated
Gene: MET
Gene Alias: AI838057; AUTS9; bHLHe59; CG1705; CG1705-PA; CG1705-PB; cmet; c-met; c-met proto-oncogene; c-Met receptor tyrosine kinase; c-Met/HGF receptor; D249; DFNB97; Dmel\CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; Met; protein tyrosin kinase; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 17295, 24553, 4233
Content And Storage: -20°C
Form: Liquid
Antigen:
c-Met
Classification:
Monoclonal
Concentration:
1000 μg/mL
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
P08581, P16056, P97523
Gene Symbols:
MET
Immunogen:
Synthetic peptide corresponding to residues surrounding Tyr1234 of human Met
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunoprecipitation, Western Blot
Clone:
K.845.5
Conjugate:
Unconjugated
Gene:
MET
Gene Alias:
AI838057; AUTS9; bHLHe59; CG1705; CG1705-PA; CG1705-PB; cmet; c-met; c-met proto-oncogene; c-Met receptor tyrosine kinase; c-Met/HGF receptor; D249; DFNB97; Dmel\CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; Met; protein tyrosin kinase; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
17295, 24553, 4233
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phospho-EGFR (Tyr1068)
Classification: Monoclonal
Concentration: 1865 μg/mL
Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.: P00533
Gene Symbols: EGFR
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding pTyr1068 of human EGF receptor
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Non-human Primate, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: S.684.2
Conjugate: Unconjugated
Gene: EGFR
Gene Alias: 2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1956, 24329
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-EGFR (Tyr1068)
Classification:
Monoclonal
Concentration:
1865 μg/mL
Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.:
P00533
Gene Symbols:
EGFR
Immunogen:
Synthetic phosphopeptide corresponding to residues surrounding pTyr1068 of human EGF receptor
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Non-human Primate, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
S.684.2
Conjugate:
Unconjugated
Gene:
EGFR
Gene Alias:
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1956, 24329
Content And Storage:
-20°C
Form:
Liquid