CLIC5 Monoclonal Antibody (CLIC5-02), Invitrogen™

Description

• Mouse monoclonal antibody CLIC5-02 recognizes CLIC5a, a 32 kDa protein which is component of actin complexes
• Crossreactivity with CLIC5b was not determined
• Clic5 encodes a protein that is required for normal hearing and is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti
• Clic5 can insert into membranes and form poorly selective ion channels that may also transport chloride ions
• Clic5 may play a role in the regulation of transepithelial ion absorption and secretion, and is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture
• The Clic5 gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels
• The protein encoded by Clic5 associates with actin-based cytoskeletal structures and may also play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance
• Alternatively spliced transcript variants encoding multiple isoforms have been observed for the Clic5 gene
• Diseases associated with CLIC5 include Deafness, Autosomal Recessive 103 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb.