Complement C5 Recombinant Rabbit Monoclonal Antibody (215), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Human Complement C5a
• The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes
• This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge
• An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase
• The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components
• Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections
• Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.