PIMA531990
Phospho-Histone H2A.X (Ser139) Recombinant Rabbit Monoclonal Antibody (SR33-09), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA531990-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA531990 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
Phospho-Histone H2A.X (Ser139)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P16104, P27661
Gene Symbols
H2AX
Immunogen
Synthetic phospho-peptide corresponding to residues surrounding Ser139 of Human Histone H2AX
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
SR33-09
Conjugate
Unconjugated
Gene
H2AX
Gene Alias
AW228881, gamma H2AX, gammaH2ax, H2A histone family member X, H2A histone family, member X, H2A.X, H2A.X variant histone, H2A/X, h2afx, H2ax, H2AX histone, Hist5-2ax, histone 5 protein 2ax, histone H2A.x, Histone H2a/x, Histone H2AX, RGD1566119, similar to H2A histone family, member X, zgc:56329
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
15270, 3014, 500987
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle
- In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX
- The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs
- The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner
- Structurally, H2A.x contains 143 amino acid residues
- Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs
- There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA
- The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA
- Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome
- Histone H2A.x contributes to histone-formation and therefore the structure of DNA
- Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.
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Antigen: Phospho-Histone H2A.X (Ser139)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P16104, P27661
Gene Symbols: H2AX
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser139 of Human Histone H2AX
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: SR33-09
Conjugate: Unconjugated
Gene: H2AX
Gene Alias: AW228881, gamma H2AX, gammaH2ax, H2A histone family member X, H2A histone family, member X, H2A.X, H2A.X variant histone, H2A/X, h2afx, H2ax, H2AX histone, Hist5-2ax, histone 5 protein 2ax, histone H2A.x, Histone H2a/x, Histone H2AX, RGD1566119, similar to H2A histone family, member X, zgc:56329
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 15270, 3014, 500987
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Phospho-Histone H2A.X (Ser139)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P16104, P27661
Gene Symbols:
H2AX
Immunogen:
Synthetic phospho-peptide corresponding to residues surrounding Ser139 of Human Histone H2AX
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
SR33-09
Conjugate:
Unconjugated
Gene:
H2AX
Gene Alias:
AW228881, gamma H2AX, gammaH2ax, H2A histone family member X, H2A histone family, member X, H2A.X, H2A.X variant histone, H2A/X, h2afx, H2ax, H2AX histone, Hist5-2ax, histone 5 protein 2ax, histone H2A.x, Histone H2a/x, Histone H2AX, RGD1566119, similar to H2A histone family, member X, zgc:56329
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
15270, 3014, 500987
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: MERTK
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: Q12866
Gene Symbols: Mertk
Immunogen: Recombinant protein within Human MERTK aa 1-118
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry, Western Blot
Clone: SR29-07
Conjugate: Unconjugated
Gene: Mertk
Gene Alias: c-Eyk, c-mer, c-mer proto-oncogene tyrosine kinase, Eyk, MER, MER proto-oncogene, tyrosine kinase, MER receptor tyrosine kinase, MERTK, MGC133349, nmf12, Nyk, Proto-oncogene c-Mer, proto-oncogene tyrosine-protein kinase MER, rdy, receptor tyrosine kinase MerTK, Receptor tyrosine tinase gene probably the gene for Rdy, retinal dystrophy, RP38, sMER, sMERTK, soluble MER, soluble MERTK, STK kinase, Tyro 12, Tyro12, Tyrosine-protein kinase Mer
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 10461
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
MERTK
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
Q12866
Gene Symbols:
Mertk
Immunogen:
Recombinant protein within Human MERTK aa 1-118
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry, Western Blot
Clone:
SR29-07
Conjugate:
Unconjugated
Gene:
Mertk
Gene Alias:
c-Eyk, c-mer, c-mer proto-oncogene tyrosine kinase, Eyk, MER, MER proto-oncogene, tyrosine kinase, MER receptor tyrosine kinase, MERTK, MGC133349, nmf12, Nyk, Proto-oncogene c-Mer, proto-oncogene tyrosine-protein kinase MER, rdy, receptor tyrosine kinase MerTK, Receptor tyrosine tinase gene probably the gene for Rdy, retinal dystrophy, RP38, sMER, sMERTK, soluble MER, soluble MERTK, STK kinase, Tyro 12, Tyro12, Tyrosine-protein kinase Mer
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
10461
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: PUMA alpha
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: Q80ZG6, Q96PG8, Q99ML1, Q9BXH1
Gene Symbols: BBC3
Immunogen: Synthetic peptide within Human PUMA aa 153-193
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SR42-09
Conjugate: Unconjugated
Gene: BBC3
Gene Alias: BBC3, BCL2 binding component 3, Bcl-2 binding component 3, bcl-2-binding component 3, Bcl-2-binding component 3, isoforms 1/2, Bcl-2-binding component 3, isoforms 3/4, BH3-only, FLJ42994, JFY1, JFY-1, p53 up-regulated modulator of apoptosis, PUMA, PUMA/JFY1
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 170770, 27113, 317673
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
PUMA alpha
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
Q80ZG6, Q96PG8, Q99ML1, Q9BXH1
Gene Symbols:
BBC3
Immunogen:
Synthetic peptide within Human PUMA aa 153-193
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SR42-09
Conjugate:
Unconjugated
Gene:
BBC3
Gene Alias:
BBC3, BCL2 binding component 3, Bcl-2 binding component 3, bcl-2-binding component 3, Bcl-2-binding component 3, isoforms 1/2, Bcl-2-binding component 3, isoforms 3/4, BH3-only, FLJ42994, JFY1, JFY-1, p53 up-regulated modulator of apoptosis, PUMA, PUMA/JFY1
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
170770, 27113, 317673
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: PI3K p55 gamma
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: Q63789, Q64143, Q92569
Gene Symbols: Pik3r3
Immunogen: Synthetic peptide within Human PI 3 Kinase p55 gamma aa 429-461.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: SR44-06
Conjugate: Unconjugated
Gene: Pik3r3
Gene Alias: AA414954, p55, p55-GAMMA, p55pik, phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55), phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, phosphatidylinositol 3-kinase p55 subunit, phosphatidylinositol 3-kinase regulatory subunit gamma, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma), phosphoinositide-3-kinase regulatory subunit 3, phosphoinositide-3-kinase, regulatory subunit 3 (gamma), PI3K regulatory subunit gamma, PI3-kinase p85 subunit gamma, PI3-kinase regulatory subunit gamma, PI3-kinase subunit p55-gamma, Pik3r3, ptdIns-3-kinase p85-gamma, ptdIns-3-kinase regulatory subunit gamma, ptdIns-3-kinase regulatory subunit p55-gamma, RP4-533D7.2
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 18710, 60664, 8503
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
PI3K p55 gamma
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
Q63789, Q64143, Q92569
Gene Symbols:
Pik3r3
Immunogen:
Synthetic peptide within Human PI 3 Kinase p55 gamma aa 429-461.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
SR44-06
Conjugate:
Unconjugated
Gene:
Pik3r3
Gene Alias:
AA414954, p55, p55-GAMMA, p55pik, phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55), phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, phosphatidylinositol 3-kinase p55 subunit, phosphatidylinositol 3-kinase regulatory subunit gamma, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma), phosphoinositide-3-kinase regulatory subunit 3, phosphoinositide-3-kinase, regulatory subunit 3 (gamma), PI3K regulatory subunit gamma, PI3-kinase p85 subunit gamma, PI3-kinase regulatory subunit gamma, PI3-kinase subunit p55-gamma, Pik3r3, ptdIns-3-kinase p85-gamma, ptdIns-3-kinase regulatory subunit gamma, ptdIns-3-kinase regulatory subunit p55-gamma, RP4-533D7.2
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
18710, 60664, 8503
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid