PIMA533114
HIF-1 beta Recombinant Rabbit Monoclonal Antibody (2F11), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533114-Each-of-1 | In Stock | ₹ 48,640.86 |
PIMA533114 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,640.86
GST (18%): ₹ 8,755.355
Total Price: ₹ 57,396.215
Antigen
HIF-1 beta
Classification
Recombinant Monoclonal
Concentration
2.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P27540
Gene Symbols
ARNT
Immunogen
A synthesized peptide derived from human ARNT
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
2F11
Conjugate
Unconjugated
Gene
ARNT
Gene Alias
AHA-1, ARNT, ARNT protein, Arnt1, ARNT1a, ARNT1b, aryl hydrocarbon receptor nuclear translocater, Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator 1, aryl hydrocarbon receptor nuclear translocator type 1a, aryl hydrocarbon receptor nuclear translocator type 1b, bHLHe2, Class E basic helix-loop-helix protein 2, D3Ertd557e, dioxin receptor, nuclear translocator, Drnt, ESTM42, hif 1, HIF1 beta, HIF-1 beta, Hif1b, HIF1BETA, HIF-1beta, HIF-1-beta, HIF1-beta, hypoxia-inducible factor 1 beta, hypoxia-inducible factor 1, beta subunit, hypoxia-inducible factor 1-beta, mKIAA4051, TANGO, W08714, zgc:136664
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
405
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Related Products
Description
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
- HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis
- This occurs as a posttranslational modification by prolyl hydroxylation
- HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits
- Both subunits are constantly translated
- However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes
- Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity
- Therefore, the concentration of HIF-1 alpha increases in the cell
- In contrast, HIF-1 beta remains stable under either condition
- HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products
- Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.
Compare Similar Items
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Antigen: HIF-1 beta
Classification: Recombinant Monoclonal
Concentration: 2.5 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.: P27540
Gene Symbols: ARNT
Immunogen: A synthesized peptide derived from human ARNT
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 2F11
Conjugate: Unconjugated
Gene: ARNT
Gene Alias: AHA-1, ARNT, ARNT protein, Arnt1, ARNT1a, ARNT1b, aryl hydrocarbon receptor nuclear translocater, Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator 1, aryl hydrocarbon receptor nuclear translocator type 1a, aryl hydrocarbon receptor nuclear translocator type 1b, bHLHe2, Class E basic helix-loop-helix protein 2, D3Ertd557e, dioxin receptor, nuclear translocator, Drnt, ESTM42, hif 1, HIF1 beta, HIF-1 beta, Hif1b, HIF1BETA, HIF-1beta, HIF-1-beta, HIF1-beta, hypoxia-inducible factor 1 beta, hypoxia-inducible factor 1, beta subunit, hypoxia-inducible factor 1-beta, mKIAA4051, TANGO, W08714, zgc:136664
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 405
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Antigen:
HIF-1 beta
Classification:
Recombinant Monoclonal
Concentration:
2.5 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
P27540
Gene Symbols:
ARNT
Immunogen:
A synthesized peptide derived from human ARNT
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
2F11
Conjugate:
Unconjugated
Gene:
ARNT
Gene Alias:
AHA-1, ARNT, ARNT protein, Arnt1, ARNT1a, ARNT1b, aryl hydrocarbon receptor nuclear translocater, Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator 1, aryl hydrocarbon receptor nuclear translocator type 1a, aryl hydrocarbon receptor nuclear translocator type 1b, bHLHe2, Class E basic helix-loop-helix protein 2, D3Ertd557e, dioxin receptor, nuclear translocator, Drnt, ESTM42, hif 1, HIF1 beta, HIF-1 beta, Hif1b, HIF1BETA, HIF-1beta, HIF-1-beta, HIF1-beta, hypoxia-inducible factor 1 beta, hypoxia-inducible factor 1, beta subunit, hypoxia-inducible factor 1-beta, mKIAA4051, TANGO, W08714, zgc:136664
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
405
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Antigen: ATF2
Classification: Recombinant Monoclonal
Concentration: 0.61 mg/mL
Formulation: PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.: P15336, P16951, Q00969
Gene Symbols: Atf2
Immunogen: A synthesized peptide derived from human ATF2
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: 3D12
Conjugate: Unconjugated
Gene: Atf2
Gene Alias: Activating 2, Activating transcription factor 2, activating transcription factor 2 splice variant ATF2-var2, ATF2, Atf-2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, CREB2, CREB-2, CRE-BP, CREBP1, CRE-BP1, Cyclic AMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, D130078H02Rik, D18875, HB16, Histone acetyltransferase ATF2, MGC111558, mXBP, MXBP protein, OTTHUMP00000205345, OTTHUMP00000205347, OTTHUMP00000205348, OTTHUMP00000205350, OTTHUMP00000205352, OTTHUMP00000205353, OTTHUMP00000205354, Tg(Gzma-Klra1)7Wum, TREB7
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 11909, 1386, 81647
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Antigen:
ATF2
Classification:
Recombinant Monoclonal
Concentration:
0.61 mg/mL
Formulation:
PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
P15336, P16951, Q00969
Gene Symbols:
Atf2
Immunogen:
A synthesized peptide derived from human ATF2
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
3D12
Conjugate:
Unconjugated
Gene:
Atf2
Gene Alias:
Activating 2, Activating transcription factor 2, activating transcription factor 2 splice variant ATF2-var2, ATF2, Atf-2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, CREB2, CREB-2, CRE-BP, CREBP1, CRE-BP1, Cyclic AMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, D130078H02Rik, D18875, HB16, Histone acetyltransferase ATF2, MGC111558, mXBP, MXBP protein, OTTHUMP00000205345, OTTHUMP00000205347, OTTHUMP00000205348, OTTHUMP00000205350, OTTHUMP00000205352, OTTHUMP00000205353, OTTHUMP00000205354, Tg(Gzma-Klra1)7Wum, TREB7
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11909, 1386, 81647
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Antigen: Phospho-ATF2 (Thr71)
Classification: Recombinant Monoclonal
Concentration: 1.02 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.: P15336
Gene Symbols: Atf2
Immunogen: A synthesized peptide derived from human Phospho-ATF2 (T71)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunocytochemistry, Western Blot
Clone: 4F2
Conjugate: Unconjugated
Gene: Atf2
Gene Alias: Activating 2, Activating transcription factor 2, activating transcription factor 2 splice variant ATF2-var2, ATF2, Atf-2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, CREB2, CREB-2, CRE-BP, CREBP1, CRE-BP1, Cyclic AMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, D130078H02Rik, D18875, HB16, Histone acetyltransferase ATF2, MGC111558, mXBP, MXBP protein, OTTHUMP00000205345, OTTHUMP00000205347, OTTHUMP00000205348, OTTHUMP00000205350, OTTHUMP00000205352, OTTHUMP00000205353, OTTHUMP00000205354, Tg(Gzma-Klra1)7Wum, TREB7
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 1386
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Antigen:
Phospho-ATF2 (Thr71)
Classification:
Recombinant Monoclonal
Concentration:
1.02 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
P15336
Gene Symbols:
Atf2
Immunogen:
A synthesized peptide derived from human Phospho-ATF2 (T71)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunocytochemistry, Western Blot
Clone:
4F2
Conjugate:
Unconjugated
Gene:
Atf2
Gene Alias:
Activating 2, Activating transcription factor 2, activating transcription factor 2 splice variant ATF2-var2, ATF2, Atf-2, cAMP response element-binding protein CRE-BP1, cAMP responsive element binding protein 2, formerly, cAMP-dependent transcription factor ATF-2, CREB2, CREB-2, CRE-BP, CREBP1, CRE-BP1, Cyclic AMP-dependent transcription factor ATF-2, cyclic AMP-responsive element-binding protein 2, D130078H02Rik, D18875, HB16, Histone acetyltransferase ATF2, MGC111558, mXBP, MXBP protein, OTTHUMP00000205345, OTTHUMP00000205347, OTTHUMP00000205348, OTTHUMP00000205350, OTTHUMP00000205352, OTTHUMP00000205353, OTTHUMP00000205354, Tg(Gzma-Klra1)7Wum, TREB7
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
1386
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Antigen: ATF4
Classification: Recombinant Monoclonal
Concentration: 1.6 mg/mL
Formulation: PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.: P18848
Gene Symbols: Atf4
Immunogen: A synthesized peptide derived from human ATF4
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunohistochemistry (Paraffin)
Clone: 9E1
Conjugate: Unconjugated
Gene: Atf4
Gene Alias: Activating transcription factor 4, activating transcription factor 4 (tax-responsive enhancer element B67), activating transcription factor 4a, activating transcription factor 4b1 (tax-responsive enhancer element B67), activating transcription factor ATF-4, ATF 4, atf4, Atf-4, atf4 {ECO:0000312, ATF4 protein, atf4a, atf4b1, C/ATF, C/EBP-related ATF, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, CREB 2, CREB2, CREB-2, Cyclic AMP-dependent transcription factor ATF-4, cyclic AMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, hypothetical protein LOC509107, OTTHUMP00000199130, rATF-4, RGD:621863}, tax-re, TaxREB67, TaxREB67 homolog, tax-responsive enhancer element B67, tax-responsive enhancer element-binding protein 67, Tax-responsive enhancer element-binding protein 67 homolog, TXREB, wu:fj01c08, wu:fk30b04, zgc:85951
Host Species: Rabbit
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 468
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Antigen:
ATF4
Classification:
Recombinant Monoclonal
Concentration:
1.6 mg/mL
Formulation:
PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.:
P18848
Gene Symbols:
Atf4
Immunogen:
A synthesized peptide derived from human ATF4
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunohistochemistry (Paraffin)
Clone:
9E1
Conjugate:
Unconjugated
Gene:
Atf4
Gene Alias:
Activating transcription factor 4, activating transcription factor 4 (tax-responsive enhancer element B67), activating transcription factor 4a, activating transcription factor 4b1 (tax-responsive enhancer element B67), activating transcription factor ATF-4, ATF 4, atf4, Atf-4, atf4 {ECO:0000312, ATF4 protein, atf4a, atf4b1, C/ATF, C/EBP-related ATF, cAMP response element-binding protein 2, cAMP-dependent transcription factor ATF-4, cAMP-responsive element-binding protein 2, CREB 2, CREB2, CREB-2, Cyclic AMP-dependent transcription factor ATF-4, cyclic AMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, hypothetical protein LOC509107, OTTHUMP00000199130, rATF-4, RGD:621863}, tax-re, TaxREB67, TaxREB67 homolog, tax-responsive enhancer element B67, tax-responsive enhancer element-binding protein 67, Tax-responsive enhancer element-binding protein 67 homolog, TXREB, wu:fj01c08, wu:fk30b04, zgc:85951
Host Species:
Rabbit
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
468
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid