PIMA542353
Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (HL122), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA542353-Each-of-1 | In Stock | ₹ 44,020.62 |
PIMA542353 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,020.62
GST (18%): ₹ 7,923.712
Total Price: ₹ 51,944.332
Antigen
Phospho-Chk1 (Ser345)
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
O14757
Gene Symbols
Chek1
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Chk1 (phosphpo Ser345).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
HL122
Conjugate
Unconjugated
Gene
Chek1
Gene Alias
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1111
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Store as concentrated solution
- Centrifuge briefly prior to opening vial
- For short-term storage (1-2 weeks), store at 4°C
- For long-term storage, aliquot and store at -20°C or below
- Avoid multiple freeze-thaw cycles
- CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
- CHK1 is a key mediator in the DNA damage-induced checkpoint network
- CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
- When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
- Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
Compare Similar Items
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Antigen: Phospho-Chk1 (Ser345)
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: O14757
Gene Symbols: Chek1
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Chk1 (phosphpo Ser345).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: HL122
Conjugate: Unconjugated
Gene: Chek1
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 1111
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
Phospho-Chk1 (Ser345)
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
O14757
Gene Symbols:
Chek1
Immunogen:
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Chk1 (phosphpo Ser345).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
HL122
Conjugate:
Unconjugated
Gene:
Chek1
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
1111
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: cIAP1
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: Q13490
Gene Symbols: BIRC2
Immunogen: Recombinant protein encompassing a sequence within the center region of human cIAP1. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: HL1045
Conjugate: Unconjugated
Gene: BIRC2
Gene Alias: Api1; Api2; apoptosis inhibitor 1; apoptosis inhibitor 2; AW146227; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; baculoviral IAP repeat-containing protein 2; baculoviral IAP repeat-containing protein 2; putative inhibitor of apoptosis; BIRC2; Birc3; cellular inhibitor of apoptosis 1; cIAP1; C-IAP1; cIAP2; HIAP1; HIAP2; Hiap-2; IAP homolog B; IAP1; IAP2; IAP-2; inhibitor of apoptosis protein; inhibitor of apoptosis protein 2; LOC100622859; mcIAP1; MIAP1; MIAP2; mIAP-2; MIHB; MIHC; NFR2-TRAF signalling complex protein; rIAP1; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; RNF48; TNFR2-TRAF-signaling complex protein 2
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 329
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
cIAP1
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
Q13490
Gene Symbols:
BIRC2
Immunogen:
Recombinant protein encompassing a sequence within the center region of human cIAP1. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
HL1045
Conjugate:
Unconjugated
Gene:
BIRC2
Gene Alias:
Api1; Api2; apoptosis inhibitor 1; apoptosis inhibitor 2; AW146227; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; baculoviral IAP repeat-containing protein 2; baculoviral IAP repeat-containing protein 2; putative inhibitor of apoptosis; BIRC2; Birc3; cellular inhibitor of apoptosis 1; cIAP1; C-IAP1; cIAP2; HIAP1; HIAP2; Hiap-2; IAP homolog B; IAP1; IAP2; IAP-2; inhibitor of apoptosis protein; inhibitor of apoptosis protein 2; LOC100622859; mcIAP1; MIAP1; MIAP2; mIAP-2; MIHB; MIHC; NFR2-TRAF signalling complex protein; rIAP1; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; RNF48; TNFR2-TRAF-signaling complex protein 2
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
329
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: EGFR (E746-A750del)
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P00533
Gene Symbols: EGFR
Immunogen: The immunogen used to generate this antibody corresponds to human EGFR (E746-A750del).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: HL363
Conjugate: Unconjugated
Gene: EGFR
Gene Alias: epidermal growth factor receptor; ERBB; ERBB1; HER1; mENA; NISBD2; PIG61
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 1956
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
EGFR (E746-A750del)
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P00533
Gene Symbols:
EGFR
Immunogen:
The immunogen used to generate this antibody corresponds to human EGFR (E746-A750del).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
HL363
Conjugate:
Unconjugated
Gene:
EGFR
Gene Alias:
epidermal growth factor receptor; ERBB; ERBB1; HER1; mENA; NISBD2; PIG61
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
1956
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: EGFR L858R
Classification: Recombinant Monoclonal
Concentration: 2 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P00533
Gene Symbols: EGFR
Immunogen: The immunogen used to generate this antibody corresponds to human EGFR (L858R Mutant).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: HL1022
Conjugate: Unconjugated
Gene: EGFR
Gene Alias: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR; Epidermal growth factor receptor; ERBB; ERBB1; erb-b2 receptor tyrosine kinase 1; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 1956
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
EGFR L858R
Classification:
Recombinant Monoclonal
Concentration:
2 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P00533
Gene Symbols:
EGFR
Immunogen:
The immunogen used to generate this antibody corresponds to human EGFR (L858R Mutant).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
HL1022
Conjugate:
Unconjugated
Gene:
EGFR
Gene Alias:
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EGFR; Epidermal growth factor receptor; ERBB; ERBB1; erb-b2 receptor tyrosine kinase 1; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
1956
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid