PIMA537019
Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (Chk1S345-R3F9), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA537019-Each-of-1 | In Stock | ₹ 31,742.76 |
PIMA537019 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,742.76
GST (18%): ₹ 5,713.697
Total Price: ₹ 37,456.457
Antigen
Phospho-Chk1 (Ser345)
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.02% sodium azide; pH 7.4
Gene Accession No.
O14757, O35280, Q91ZN7
Gene Symbols
Chek1
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG κ
Applications
Flow Cytometry
Clone
Chk1S345-R3F9
Conjugate
Unconjugated
Gene
Chek1
Gene Alias
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species
Rabbit
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
1111, 12649, 140583
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised
- CHK1 is a key mediator in the DNA damage-induced checkpoint network
- CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress
- When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase
- Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
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Antigen: Phospho-Chk1 (Ser345)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.02% sodium azide; pH 7.4
Gene Accession No.: O14757, O35280, Q91ZN7
Gene Symbols: Chek1
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Quantity: 20 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG κ
Applications: Flow Cytometry
Clone: Chk1S345-R3F9
Conjugate: Unconjugated
Gene: Chek1
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species: Rabbit
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 1111, 12649, 140583
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-Chk1 (Ser345)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.02% sodium azide; pH 7.4
Gene Accession No.:
O14757, O35280, Q91ZN7
Gene Symbols:
Chek1
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Quantity:
20 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG κ
Applications:
Flow Cytometry
Clone:
Chk1S345-R3F9
Conjugate:
Unconjugated
Gene:
Chek1
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species:
Rabbit
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
1111, 12649, 140583
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phospho-Chk1 (Ser345)
Classification: Monoclonal
Concentration: __
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Accession No.: O14757, O35280, Q91ZN7
Gene Symbols: Chek1
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG κ
Applications: Flow Cytometry
Clone: Chk1S345-R3F9
Conjugate: APC
Gene: Chek1
Gene Alias: C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species: Rabbit
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 1111, 12649, 140583
Content And Storage: 4° C
Form: Liquid
Antigen:
Phospho-Chk1 (Ser345)
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Accession No.:
O14757, O35280, Q91ZN7
Gene Symbols:
Chek1
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1.
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG κ
Applications:
Flow Cytometry
Clone:
Chk1S345-R3F9
Conjugate:
APC
Gene:
Chek1
Gene Alias:
C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W
Host Species:
Rabbit
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
1111, 12649, 140583
Content And Storage:
4° C
Form:
Liquid
Antigen: Phospho-Histone H2A.X (Ser139)
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: P16104, P27661
Gene Symbols: H2AX
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Quantity: 20 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG κ
Applications: Flow Cytometry, Immunocytochemistry, Western Blot
Clone: HisH2AXS139-1B3
Conjugate: Unconjugated
Gene: H2AX
Gene Alias: AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species: Rabbit
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 15270, 3014
Content And Storage: -20°C
Form: Liquid
Antigen:
Phospho-Histone H2A.X (Ser139)
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
P16104, P27661
Gene Symbols:
H2AX
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Quantity:
20 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG κ
Applications:
Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
HisH2AXS139-1B3
Conjugate:
Unconjugated
Gene:
H2AX
Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species:
Rabbit
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
15270, 3014
Content And Storage:
-20°C
Form:
Liquid
Antigen: Phospho-Histone H2A.X (Ser139)
Classification: Monoclonal
Concentration: __
Formulation: PBS with 0.20% BSA and 0.09% sodium azide
Gene Accession No.: P16104, P27661
Gene Symbols: H2AX
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG κ
Applications: Flow Cytometry
Clone: HisH2AXS139-1B3
Conjugate: PE
Gene: H2AX
Gene Alias: AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species: Rabbit
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 15270, 3014
Content And Storage: 4° C
Form: Liquid
Antigen:
Phospho-Histone H2A.X (Ser139)
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with 0.20% BSA and 0.09% sodium azide
Gene Accession No.:
P16104, P27661
Gene Symbols:
H2AX
Immunogen:
A synthetic phospho-peptide corresponding to residues surrounding Ser139 of human phospho histone H2A.X.
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG κ
Applications:
Flow Cytometry
Clone:
HisH2AXS139-1B3
Conjugate:
PE
Gene:
H2AX
Gene Alias:
AW228881; gamma H2AX; gammaH2ax; H2A histone family member X; H2A histone family, member X; H2A.X; H2A.X variant histone; H2A/X; h2afx; H2ax; H2AX histone; Hist5-2ax; histone 5 protein 2ax; histone H2A.x; Histone H2a/x; Histone H2AX; RGD1566119; similar to H2A histone family, member X; zgc:56329
Host Species:
Rabbit
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
15270, 3014
Content And Storage:
4° C
Form:
Liquid