PIMA544240
Granzyme B Recombinant Rabbit Monoclonal Antibody (BLR022E), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544240-Each-of-1 | In Stock | ₹ 13,492.81 |
PIMA544240 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 13,492.81
GST (18%): ₹ 2,428.706
Total Price: ₹ 15,921.516
Antigen
Granzyme B
Classification
Recombinant Monoclonal
Concentration
50 μg/mL
Formulation
BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.
P10144
Gene Symbols
GZMB
Immunogen
Residues 19-247 (Mature Protein)
Quantity
10 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Inhibition Assays, Western Blot
Clone
BLR022E
Conjugate
Unconjugated
Gene
GZMB
Gene Alias
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species
Rabbit
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
3002
Content And Storage
2-8°C
Form
Liquid
Related Products
Description
- Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections
- Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells
- Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells
- Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells
- The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis
- Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis
- Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein
- Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells
- A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
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Antigen: Granzyme B
Classification: Recombinant Monoclonal
Concentration: 50 μg/mL
Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.: P10144
Gene Symbols: GZMB
Immunogen: Residues 19-247 (Mature Protein)
Quantity: 10 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Inhibition Assays, Western Blot
Clone: BLR022E
Conjugate: Unconjugated
Gene: GZMB
Gene Alias: AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species: Rabbit
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 3002
Content And Storage: 2-8°C
Form: Liquid
Antigen:
Granzyme B
Classification:
Recombinant Monoclonal
Concentration:
50 μg/mL
Formulation:
BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.:
P10144
Gene Symbols:
GZMB
Immunogen:
Residues 19-247 (Mature Protein)
Quantity:
10 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Inhibition Assays, Western Blot
Clone:
BLR022E
Conjugate:
Unconjugated
Gene:
GZMB
Gene Alias:
AI553453; C11; Cathepsin G-like 1; CCP1; CCP-1/C11; CCPI; CGL1; CGL-1; CSPB; CSP-B; Ctla1; Ctla-1; CTSGL1; cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme-2; GranzymeB; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; Gzmb; HLP; human lymphocyte protein; Human lymphocyte protein (Hlp); Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Host Species:
Rabbit
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
3002
Content And Storage:
2-8°C
Form:
Liquid
Antigen: FUS
Classification: Recombinant Monoclonal
Concentration: 30 μg/mL
Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.: P35637, P56959
Gene Symbols: FUS
Immunogen: Between 1 And 50
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: BLR023E
Conjugate: Unconjugated
Gene: FUS
Gene Alias: 16) in malignant liposarcoma); 16) malignant liposarcoma; 75 kDa DNA-pairing protein; ALS6; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS RNA binding protein; Fus1; fused in sarcoma; fused in sarcoma RNA binding protein; fusion (involved in t(12; fusion gene in myxoid liposarcoma; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma; fus-like protein; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; HNRNPP2; oncogene FUS; Oncogene TLS; pigpen protein; POMP75; Protein pigpen; RNA-binding protein FUS; TLS; translocated in liposarcoma; translocated in liposarcoma protein
Host Species: Rabbit
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 233908, 2521
Content And Storage: 2-8°C
Form: Liquid
Antigen:
FUS
Classification:
Recombinant Monoclonal
Concentration:
30 μg/mL
Formulation:
BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.:
P35637, P56959
Gene Symbols:
FUS
Immunogen:
Between 1 And 50
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
BLR023E
Conjugate:
Unconjugated
Gene:
FUS
Gene Alias:
16) in malignant liposarcoma); 16) malignant liposarcoma; 75 kDa DNA-pairing protein; ALS6; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS RNA binding protein; Fus1; fused in sarcoma; fused in sarcoma RNA binding protein; fusion (involved in t(12; fusion gene in myxoid liposarcoma; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma; fus-like protein; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; HNRNPP2; oncogene FUS; Oncogene TLS; pigpen protein; POMP75; Protein pigpen; RNA-binding protein FUS; TLS; translocated in liposarcoma; translocated in liposarcoma protein
Host Species:
Rabbit
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
233908, 2521
Content And Storage:
2-8°C
Form:
Liquid
Antigen: FUS
Classification: Recombinant Monoclonal
Concentration: 30 μg/mL
Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.: P35637, P56959
Gene Symbols: FUS
Immunogen: Between 1 And 50
Quantity: 20 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: BLR023E
Conjugate: Unconjugated
Gene: FUS
Gene Alias: 16) in malignant liposarcoma); 16) malignant liposarcoma; 75 kDa DNA-pairing protein; ALS6; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS RNA binding protein; Fus1; fused in sarcoma; fused in sarcoma RNA binding protein; fusion (involved in t(12; fusion gene in myxoid liposarcoma; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma; fus-like protein; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; HNRNPP2; oncogene FUS; Oncogene TLS; pigpen protein; POMP75; Protein pigpen; RNA-binding protein FUS; TLS; translocated in liposarcoma; translocated in liposarcoma protein
Host Species: Rabbit
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 233908, 2521
Content And Storage: 2-8°C
Form: Liquid
Antigen:
FUS
Classification:
Recombinant Monoclonal
Concentration:
30 μg/mL
Formulation:
BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.:
P35637, P56959
Gene Symbols:
FUS
Immunogen:
Between 1 And 50
Quantity:
20 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
BLR023E
Conjugate:
Unconjugated
Gene:
FUS
Gene Alias:
16) in malignant liposarcoma); 16) malignant liposarcoma; 75 kDa DNA-pairing protein; ALS6; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS RNA binding protein; Fus1; fused in sarcoma; fused in sarcoma RNA binding protein; fusion (involved in t(12; fusion gene in myxoid liposarcoma; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma; fus-like protein; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; HNRNPP2; oncogene FUS; Oncogene TLS; pigpen protein; POMP75; Protein pigpen; RNA-binding protein FUS; TLS; translocated in liposarcoma; translocated in liposarcoma protein
Host Species:
Rabbit
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
233908, 2521
Content And Storage:
2-8°C
Form:
Liquid
Antigen: SETD1A
Classification: Recombinant Monoclonal
Concentration: 10 μg/mL
Formulation: BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.: O15047
Gene Symbols: SETD1A
Immunogen: Between 1200 And 1250
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: BLR024E
Conjugate: Unconjugated
Gene: SETD1A
Gene Alias: BC010250; Histone-lysine N-methyltransferase SETD1A; hSET1A; KIAA0339; KMT2F; Lysine N-methyltransferase 2F; mKIAA0339; mNSC1; non-selective cation channel 1; Nsccn1; SET domain containing 1A; SET domain-containing protein 1A; SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A; SETD1A
Host Species: Rabbit
Purification Method: purified
Regulatory Status: RUO
Gene ID (Entrez): 233904, 9739
Content And Storage: 2-8°C
Form: Liquid
Antigen:
SETD1A
Classification:
Recombinant Monoclonal
Concentration:
10 μg/mL
Formulation:
BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Gene Accession No.:
O15047
Gene Symbols:
SETD1A
Immunogen:
Between 1200 And 1250
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
BLR024E
Conjugate:
Unconjugated
Gene:
SETD1A
Gene Alias:
BC010250; Histone-lysine N-methyltransferase SETD1A; hSET1A; KIAA0339; KMT2F; Lysine N-methyltransferase 2F; mKIAA0339; mNSC1; non-selective cation channel 1; Nsccn1; SET domain containing 1A; SET domain-containing protein 1A; SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; SET1A; SETD1A
Host Species:
Rabbit
Purification Method:
purified
Regulatory Status:
RUO
Gene ID (Entrez):
233904, 9739
Content And Storage:
2-8°C
Form:
Liquid