PIPA596161
Granzyme B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596161-Each-of-1 | In Stock | ₹ 44,277.30 |
PIPA596161 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,277.30
GST (18%): ₹ 7,969.914
Total Price: ₹ 52,247.214
Antigen
Granzyme B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
GZMB
Gene Alias
AI553453, C11, Cathepsin G-like 1, CCP1, CCP-1/C11, CCPI, CGL1, CGL-1, CSPB, CSP-B, Ctla1, Ctla-1, CTSGL1, cytotoxic cell protease 1, cytotoxic serine protease B, Cytotoxic T lymphocyte associated serine esterase 1, cytotoxic T-lymphocyte proteinase 2, cytotoxic T-lymphocyte-associated serine esterase 1, fragmentin, fragmentin 2, fragmentin-2, GLP I, GLP III, GLP-1, granzyme 2, granzyme B, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), granzyme B(G,H), Granzyme-2, GranzymeB, granzyme-like protein 1, granzyme-like protein I, GRB, GZB, Gzmb, HLP, human lymphocyte protein, Human lymphocyte protein (Hlp), Lymphocyte protease, Natural killer cell protease 1, OTTHUMP00000028189, RNKP-1, SECT, T-cell serine protease 1-3E
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
14939, 171528, 3002
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1.77 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.
P04187, P10144, P18291
Gene Symbols
GZMB
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Granzyme B (NP_0041222)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: YNPKNFSNDI MLLQLERKAK RTRAVQPLRL PSNKAQVKPG QTCSVAGWGQ TAPLGKHSHT LQEVKMTVQE DRKCESDLRH YYDSTIELCV GDPEIKKTSF K; Positive Samples: Mouse spleen, Mouse lung, Mouse thymus; Cellular Location: Cytoplasmic granule Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells
- Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells
- Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells
- The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis
- Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis
- Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein
- Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells
- A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
Compare Similar Items
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Antigen: Granzyme B
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GZMB
Gene Alias: AI553453, C11, Cathepsin G-like 1, CCP1, CCP-1/C11, CCPI, CGL1, CGL-1, CSPB, CSP-B, Ctla1, Ctla-1, CTSGL1, cytotoxic cell protease 1, cytotoxic serine protease B, Cytotoxic T lymphocyte associated serine esterase 1, cytotoxic T-lymphocyte proteinase 2, cytotoxic T-lymphocyte-associated serine esterase 1, fragmentin, fragmentin 2, fragmentin-2, GLP I, GLP III, GLP-1, granzyme 2, granzyme B, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), granzyme B(G,H), Granzyme-2, GranzymeB, granzyme-like protein 1, granzyme-like protein I, GRB, GZB, Gzmb, HLP, human lymphocyte protein, Human lymphocyte protein (Hlp), Lymphocyte protease, Natural killer cell protease 1, OTTHUMP00000028189, RNKP-1, SECT, T-cell serine protease 1-3E
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 14939, 171528, 3002
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration: 1.77 mg/mL
Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.: P04187, P10144, P18291
Gene Symbols: GZMB
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Granzyme B (NP_0041222)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Granzyme B
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GZMB
Gene Alias:
AI553453, C11, Cathepsin G-like 1, CCP1, CCP-1/C11, CCPI, CGL1, CGL-1, CSPB, CSP-B, Ctla1, Ctla-1, CTSGL1, cytotoxic cell protease 1, cytotoxic serine protease B, Cytotoxic T lymphocyte associated serine esterase 1, cytotoxic T-lymphocyte proteinase 2, cytotoxic T-lymphocyte-associated serine esterase 1, fragmentin, fragmentin 2, fragmentin-2, GLP I, GLP III, GLP-1, granzyme 2, granzyme B, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), granzyme B(G,H), Granzyme-2, GranzymeB, granzyme-like protein 1, granzyme-like protein I, GRB, GZB, Gzmb, HLP, human lymphocyte protein, Human lymphocyte protein (Hlp), Lymphocyte protease, Natural killer cell protease 1, OTTHUMP00000028189, RNKP-1, SECT, T-cell serine protease 1-3E
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14939, 171528, 3002
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration:
1.77 mg/mL
Formulation:
PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
Gene Accession No.:
P04187, P10144, P18291
Gene Symbols:
GZMB
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Granzyme B (NP_0041222)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: DIABLO
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DIABLO
Gene Alias: 0610041G12Rik, 1700006L01Rik, AU040403, DFNA64, DIABLO, diablo homolog (Drosophila), diablo homolog, mitochondrial, diablo IAP-binding mitochondrial protein, diablo, IAP-binding mitochondrial protein, diablo-like protein, DIABLO-S, direct IAP binding protein with low PI, direct IAP-binding protein with low pI, FLJ10537, FLJ25049, hCG_1782202, Second mitochondria-derived activator of caspase, Smac, Smac protein, SMAC3
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 288753, 56616, 66593
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1.93 mg/mL
Formulation: PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.: Q9JIQ3, Q9NR28
Gene Symbols: DIABLO
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_0639401)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
DIABLO
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DIABLO
Gene Alias:
0610041G12Rik, 1700006L01Rik, AU040403, DFNA64, DIABLO, diablo homolog (Drosophila), diablo homolog, mitochondrial, diablo IAP-binding mitochondrial protein, diablo, IAP-binding mitochondrial protein, diablo-like protein, DIABLO-S, direct IAP binding protein with low PI, direct IAP-binding protein with low pI, FLJ10537, FLJ25049, hCG_1782202, Second mitochondria-derived activator of caspase, Smac, Smac protein, SMAC3
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
288753, 56616, 66593
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1.93 mg/mL
Formulation:
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.:
Q9JIQ3, Q9NR28
Gene Symbols:
DIABLO
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_0639401)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: AIF
Classification: Polyclonal
Conjugate: Unconjugated
Gene: AIFM1
Gene Alias: AG1, AGR1, Aif, AIFM1, AIFsh2, apoptosis inducing factor mitochondria associated 1, apoptosis inducing factor, mitochondria associated 1, apoptosis-inducing factor 1, mitochondrial, apoptosis-inducing factor, mitochondrion-associated 1, apoptosis-inducing factor, mitochondrion-associated, 1, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, ER protein 18, ER protein 19, ERP18, ERP19, hAG-1, harlequin, Hq, hTLP19, MGC111425, mitochondrial apoptosis-inducing factor 1, NADMR, NAMSD, pcd8, PDCD8, PDIA16, programmed cell death 8 (apoptosis-inducing factor), programmed cell death protein 8, RP3-438D16.2, striatal apoptosis-inducing factor, testicular secretory protein Li 4, TLP19, UNQ713/PRO1376
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 26926, 83533, 9131
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin)
Concentration: 0.58 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: O95831, Q9JM53, Q9Z0X1
Gene Symbols: AIFM1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 334-613 of human AIF (NP_0041991)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
AIF
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
AIFM1
Gene Alias:
AG1, AGR1, Aif, AIFM1, AIFsh2, apoptosis inducing factor mitochondria associated 1, apoptosis inducing factor, mitochondria associated 1, apoptosis-inducing factor 1, mitochondrial, apoptosis-inducing factor, mitochondrion-associated 1, apoptosis-inducing factor, mitochondrion-associated, 1, CMT2D, CMTX4, COWCK, COXPD6, DFNX5, ER protein 18, ER protein 19, ERP18, ERP19, hAG-1, harlequin, Hq, hTLP19, MGC111425, mitochondrial apoptosis-inducing factor 1, NADMR, NAMSD, pcd8, PDCD8, PDIA16, programmed cell death 8 (apoptosis-inducing factor), programmed cell death protein 8, RP3-438D16.2, striatal apoptosis-inducing factor, testicular secretory protein Li 4, TLP19, UNQ713/PRO1376
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
26926, 83533, 9131
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin)
Concentration:
0.58 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
O95831, Q9JM53, Q9Z0X1
Gene Symbols:
AIFM1
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 334-613 of human AIF (NP_0041991)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: PDCD4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PDCD4
Gene Alias: D19Ucla1, death up-regulated gene protein, death-upregulated, Dug, H731, Ma3, MGC33046, MGC33047, Neoplastic transformation inhibitor protein, nuclear antigen H731, Nuclear antigen H731-like, Pdcd4, programmed cell death 4, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death protein 4, Protein 197/15a, protein MA-3, RP11-348N5.4, Tis, topoisomerase-inhibitor suppressed protein
Host Species: Rabbit
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 18569, 27250
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: 0.3 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.: Q53EL6, Q61823
Gene Symbols: PDCD4
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PDCD4 (NP_0552712)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
PDCD4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PDCD4
Gene Alias:
D19Ucla1, death up-regulated gene protein, death-upregulated, Dug, H731, Ma3, MGC33046, MGC33047, Neoplastic transformation inhibitor protein, nuclear antigen H731, Nuclear antigen H731-like, Pdcd4, programmed cell death 4, programmed cell death 4 (neoplastic transformation inhibitor), programmed cell death protein 4, Protein 197/15a, protein MA-3, RP11-348N5.4, Tis, topoisomerase-inhibitor suppressed protein
Host Species:
Rabbit
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
18569, 27250
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
0.3 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.:
Q53EL6, Q61823
Gene Symbols:
PDCD4
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PDCD4 (NP_0552712)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG