PIPA5105697
Phospho-LATS2 (Ser380) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105697-Each-of-1 | In Stock | ₹ 42,394.98 |
PIPA5105697 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,394.98
GST (18%): ₹ 7,631.096
Total Price: ₹ 50,026.076
Antigen
Phospho-LATS2 (Ser380)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
LATS2
Gene Alias
4932411G09Rik, AV277261, AW228608, h-warts, Kinase phosphorylated during mitosis protein, KPM, large tumor suppressor 2, large tumor suppressor homolog 2, large tumor suppressor kinase 2, large tumor suppressor, homolog 2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, LATS2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, si:ch211-173o4.2, Warts-like kinase
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
26524, 50523
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q7TSJ6, Q9NRM7
Gene Symbols
LATS2
Immunogen
A synthesized peptide derived from human LATS2(Accession Q9NRM7), corresponding to amino acid residues around phosphorylated Ser380.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of LATS2 only when phosphorylated at Ser380
- LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family
- LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction
- LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity
- LATS2 plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration
- It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
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Antigen: Phospho-LATS2 (Ser380)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: LATS2
Gene Alias: 4932411G09Rik, AV277261, AW228608, h-warts, Kinase phosphorylated during mitosis protein, KPM, large tumor suppressor 2, large tumor suppressor homolog 2, large tumor suppressor kinase 2, large tumor suppressor, homolog 2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, LATS2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, si:ch211-173o4.2, Warts-like kinase
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 26524, 50523
Content And Storage: -20°C
Form: Liquid
Applications: Immunocytochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q7TSJ6, Q9NRM7
Gene Symbols: LATS2
Immunogen: A synthesized peptide derived from human LATS2(Accession Q9NRM7), corresponding to amino acid residues around phosphorylated Ser380.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-LATS2 (Ser380)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
LATS2
Gene Alias:
4932411G09Rik, AV277261, AW228608, h-warts, Kinase phosphorylated during mitosis protein, KPM, large tumor suppressor 2, large tumor suppressor homolog 2, large tumor suppressor kinase 2, large tumor suppressor, homolog 2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, LATS2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, si:ch211-173o4.2, Warts-like kinase
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
26524, 50523
Content And Storage:
-20°C
Form:
Liquid
Applications:
Immunocytochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q7TSJ6, Q9NRM7
Gene Symbols:
LATS2
Immunogen:
A synthesized peptide derived from human LATS2(Accession Q9NRM7), corresponding to amino acid residues around phosphorylated Ser380.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-PERK (Ser555)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: EIF2AK3
Gene Alias: 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9451
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q9NZJ5
Gene Symbols: EIF2AK3
Immunogen: A synthesized peptide derived from human EIF2AK3(Accession Q9NZJ5), corresponding to amino acid residues around phosphorylated Ser555.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-PERK (Ser555)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
EIF2AK3
Gene Alias:
2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9451
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q9NZJ5
Gene Symbols:
EIF2AK3
Immunogen:
A synthesized peptide derived from human EIF2AK3(Accession Q9NZJ5), corresponding to amino acid residues around phosphorylated Ser555.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-TACC3 (Tyr560)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TACC3
Gene Alias: Aint; Arnt interacting protein; ARNT-interacting protein; C86661; ERIC1; ERIC-1; Tacc3; transforming acidic coiled coil 3; transforming acidic coiled-coil containing protein 3; transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10460, 21335, 360962
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q9JJ11, Q9Y6A5
Gene Symbols: TACC3
Immunogen: A synthesized peptide derived from human TACC3(Accession Q9Y6A5), corresponding to amino acid residues around phosphorylated Tyr560.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-TACC3 (Tyr560)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TACC3
Gene Alias:
Aint; Arnt interacting protein; ARNT-interacting protein; C86661; ERIC1; ERIC-1; Tacc3; transforming acidic coiled coil 3; transforming acidic coiled-coil containing protein 3; transforming acidic coiled-coil-containing protein 3; transforming, acidic coiled-coil containing protein 3
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10460, 21335, 360962
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q9JJ11, Q9Y6A5
Gene Symbols:
TACC3
Immunogen:
A synthesized peptide derived from human TACC3(Accession Q9Y6A5), corresponding to amino acid residues around phosphorylated Tyr560.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Phospho-Cdc20 (Thr70)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CDC20
Gene Alias: 2310042N09Rik; bA276H19.3; C87100; cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55cdc; XELAEV_18025163mg; X-FZY
Host Species: Rabbit
Purification Method: sequential chromatography
Regulatory Status: RUO
Gene ID (Entrez): 107995, 64515, 991
Content And Storage: -20°C
Form: Liquid
Applications: Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.: Q12834, Q62623, Q9JJ66
Gene Symbols: CDC20
Immunogen: A synthesized peptide derived from human CDC20(Accession Q12834), corresponding to amino acid residues around phosphorylated Thr70.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Phospho-Cdc20 (Thr70)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CDC20
Gene Alias:
2310042N09Rik; bA276H19.3; C87100; cdc20; CDC20 cell division cycle 20 homolog; cdc20.S; CDC20A; cell cycle protein p55CDC; cell division cycle 20; cell division cycle 20 homolog; cell division cycle 20 S homeolog; cell division cycle protein 20 homolog; fizzy1; mmCdc20; p55cdc; XELAEV_18025163mg; X-FZY
Host Species:
Rabbit
Purification Method:
sequential chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
107995, 64515, 991
Content And Storage:
-20°C
Form:
Liquid
Applications:
Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.:
Q12834, Q62623, Q9JJ66
Gene Symbols:
CDC20
Immunogen:
A synthesized peptide derived from human CDC20(Accession Q12834), corresponding to amino acid residues around phosphorylated Thr70.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG