PIPA5143364

Phospho-Tau (Thr181) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIPA5143364-Each-of-1 In Stock ₹ 37,903.08

PIPA5143364 - Each of 1

₹ 37,903.08

In Stock

Quantity

1

Base Price: ₹ 37,903.08

GST (18%): ₹ 6,822.554

Total Price: ₹ 44,725.634

Antigen

Phospho-Tau (Thr181)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

MAPT

Gene Alias

AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)

Host Species

Rabbit

Purification Method

Antigen affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

17762, 29477, 4137

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Applications

Immunohistochemistry (Paraffin), Western Blot

Concentration

1.14 mg/mL

Formulation

PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7

Gene Accession No.

P10636, P10637, P19332

Gene Symbols

MAPT

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Thr181 of human Tau. The exact sequence is proprietary.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Store as concentrated solution
  • Centrifuge briefly prior to opening vial
  • Tau is a neuronal microtubule-associated protein found predominantly on axons
  • The function of Tau is to promote tubulin polymerization and stabilize microtubules
  • The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both
  • Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome
  • The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization
  • In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain
  • Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, μgtimately leading to the degeneration of the affected neurons
  • Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II
  • Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Compare Similar Items

Show Difference

Img

Thermo Scientific

PIPA5143364

--


Antigen:
Phospho-Tau (Thr181)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
MAPT

Gene Alias:
AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
17762, 29477, 4137

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Western Blot

Concentration:
1.14 mg/mL

Formulation:
PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7

Gene Accession No.:
P10636, P10637, P19332

Gene Symbols:
MAPT

Immunogen:
Carrier-protein conjugated synthetic peptide surrounding phospho Thr181 of human Tau. The exact sequence is proprietary.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5143365

--


Antigen:
Gad1b

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
67 kDa glutamic acid decarboxylase; 67kDa glutamate decarboxylase 1; CPSQ1; EGK_04525; EP10; FLJ45882; GAD; GAD 1; GAD 67; GAD1; Gad-1; GAD25; GAD44; Gad67; GAD-67; Glutamate decarboxylase 1; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1 isoform GAD67; glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 67 kDa isoform; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); glutamic acid decarboxylase; glutamic acid decarboxylase 1; glutamic acid decarboxylase isoform 67; OTTHUMP00000041055; SCP

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot

Concentration:
0.53 mg/mL

Formulation:
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
The immunogen used to generate this antibody corresponds to zebrafish GAD67

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Zebrafish

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA5143367

--


Antigen:
Cardiac Troponin C

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
AI874626; cardiac 3; cardiac troponin C; Cardiac troponin I; CMD1FF; CMD1Z; CMD2A; CMH13; CMH7; cTnC; cTnI; MGC116817; RCM1; slow twitch skeletal/cardiac muscle troponin C; Tn1; TnC; TN-C; Tncc; Tni; TNN I3; TNNC; TNNC 1; Tnnc1; TNNI3; troponin C type 1 (slow); troponin C, cardiac/slow skeletal; troponin C, slow skeletal and cardiac muscles; troponin C1, slow; troponin C1, slow skeletal and cardiac type; Troponin I; Troponin I cardiac; TroponinI

Host Species:
Rabbit

Purification Method:
Antigen affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry (PFA fixed)

Concentration:
0.56 mg/mL

Formulation:
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
The immunogen used to generate this antibody corresponds to zebrafish Tnnc1a+b

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Zebrafish

Product Type:
Antibody

Isotype:
IgG

Img

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PIPA5143368

--


Antigen:
PABPC1b

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
__

Gene Alias:
pabpc1; poly A binding protein, cytoplasmic 1 b; zgc:77608

Host Species:
Rabbit

Purification Method:
Protein A

Regulatory Status:
RUO

Gene ID (Entrez):
__

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Applications:
Immunohistochemistry (PFA fixed)

Concentration:
5.95 mg/mL

Formulation:
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
The immunogen used to generate this antibody corresponds to zebrafish Pabpc1b

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Zebrafish

Product Type:
Antibody

Isotype:
IgG