PIPA5143660
Phospho-N-cadherin/E-cadherin (Tyr820, Tyr835, Tyr860) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143660-Each-of-1 | In Stock | ₹ 44,106.18 |
PIPA5143660 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,106.18
GST (18%): ₹ 7,939.112
Total Price: ₹ 52,045.292
Antigen
Phospho-N-cadherin/E-cadherin (Tyr820, Tyr835, Tyr860)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CDH2
Gene Alias
Cadherin-2; CD325
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1000, 12558, 83501
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
P15116, P19022, Q9Z1Y3
Gene Symbols
CDH2
Immunogen
Phospho-N-Cadherin (Tyr-860) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding tyrosine 860 in human N-cadherin. This sequence is conserved in human E-cadherin (Tyr-835), P-cadherin (Tyr-782), R-cadherin (Tyr-870), and has significant homology to VE-Cadherin (Tyr-733).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- This antibody was cross-adsorbed to phospho-N-Cadherin (Tyr-820) and unphosphorylated N-cadherin (Tyr-860) peptides before affinity purification using phospho-N-cadherin (Tyr-860) peptide
- In western blots, the antibody detects a 130 kDa* band corresponding to N-cadherin (Tyr-860) in human endothelial cells treated with pervanadate and detects a 120 kDa band corresponding to E-cadherin (Tyr-835) in human A431 cells treated with pervanadate
- Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation
- Cadherins cluster to form foci of homophilic binding units
- A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins
- This region induces clustering and also binds to the protein p120 catenin
- The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton
- Many cadherins are regulated by phosphorylation, including N-cadherin and E-cadherin
- N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr-886
- Phosphorylation of Tyr-860 can disrupt cadherin binding to beta-catenin
- Since many of these tyrosine sites are conserved in the cadherin family, phosphorylation of these sites may be critical for cadherin function.
Compare Similar Items
Show Difference
Antigen: Phospho-N-cadherin/E-cadherin (Tyr820, Tyr835, Tyr860)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CDH2
Gene Alias: Cadherin-2; CD325
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1000, 12558, 83501
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P15116, P19022, Q9Z1Y3
Gene Symbols: CDH2
Immunogen: Phospho-N-Cadherin (Tyr-860) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding tyrosine 860 in human N-cadherin. This sequence is conserved in human E-cadherin (Tyr-835), P-cadherin (Tyr-782), R-cadherin (Tyr-870), and has significant homology to VE-Cadherin (Tyr-733).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-N-cadherin/E-cadherin (Tyr820, Tyr835, Tyr860)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CDH2
Gene Alias:
Cadherin-2; CD325
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1000, 12558, 83501
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P15116, P19022, Q9Z1Y3
Gene Symbols:
CDH2
Immunogen:
Phospho-N-Cadherin (Tyr-860) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding tyrosine 860 in human N-cadherin. This sequence is conserved in human E-cadherin (Tyr-835), P-cadherin (Tyr-782), R-cadherin (Tyr-870), and has significant homology to VE-Cadherin (Tyr-733).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: Phospho-beta Catenin/gamma Catenin (Tyr142, Tyr133)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTNNB1
Gene Alias: Catenin beta1; CTNNB1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12387, 1499, 84353
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P35222, Q02248, Q9WU82
Gene Symbols: CTNNB1
Immunogen: Phospho-beta-Catenin (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 142 of human beta-Catenin. This peptide sequence has one amino acid difference from a sequence around tyrosine 133 of human gamma-Catenin. These human sequences are highly conserved in rat and mouse beta- and gamma-Catenins.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-beta Catenin/gamma Catenin (Tyr142, Tyr133)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTNNB1
Gene Alias:
Catenin beta1; CTNNB1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12387, 1499, 84353
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P35222, Q02248, Q9WU82
Gene Symbols:
CTNNB1
Immunogen:
Phospho-beta-Catenin (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 142 of human beta-Catenin. This peptide sequence has one amino acid difference from a sequence around tyrosine 133 of human gamma-Catenin. These human sequences are highly conserved in rat and mouse beta- and gamma-Catenins.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: Phospho-beta Catenin/gamma Catenin (Tyr489, Tyr480)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTNNB1
Gene Alias: Catenin beta1; CTNNB1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12387, 1499, 84353
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P35222, Q02248, Q9WU82
Gene Symbols: CTNNB1
Immunogen: Phospho-beta-Catenin (Tyr-489) synthetic peptide corresponds to amino acid residues around tyrosine 489 of human beta-Catenin. This peptide sequence is highly conserved in rat and mouse beta-Catenin, and has high homology to the conserved site in gamma-Catenin (Tyr-480).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-beta Catenin/gamma Catenin (Tyr489, Tyr480)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTNNB1
Gene Alias:
Catenin beta1; CTNNB1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12387, 1499, 84353
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P35222, Q02248, Q9WU82
Gene Symbols:
CTNNB1
Immunogen:
Phospho-beta-Catenin (Tyr-489) synthetic peptide corresponds to amino acid residues around tyrosine 489 of human beta-Catenin. This peptide sequence is highly conserved in rat and mouse beta-Catenin, and has high homology to the conserved site in gamma-Catenin (Tyr-480).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: Phospho-beta Catenin/gamma Catenin (Tyr654, Tyr644)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTNNB1
Gene Alias: Catenin beta1; CTNNB1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12387, 1499, 84353
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: 0.25 mg/mL
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P35222, Q02248, Q9WU82
Gene Symbols: CTNNB1
Immunogen: Phospho-beta-Catenin (Tyr-654) synthetic peptide corresponds to amino acid residues around tyrosine 654 of human beta-Catenin. This peptide sequence is highly conserved in rat, mouse, chicken, and frog beta-Catenins, and has high homology to the conserved site in gamma-Catenin (Tyr-644).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-beta Catenin/gamma Catenin (Tyr654, Tyr644)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTNNB1
Gene Alias:
Catenin beta1; CTNNB1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12387, 1499, 84353
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.25 mg/mL
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P35222, Q02248, Q9WU82
Gene Symbols:
CTNNB1
Immunogen:
Phospho-beta-Catenin (Tyr-654) synthetic peptide corresponds to amino acid residues around tyrosine 654 of human beta-Catenin. This peptide sequence is highly conserved in rat, mouse, chicken, and frog beta-Catenins, and has high homology to the conserved site in gamma-Catenin (Tyr-644).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid