PIPA5143664
Phospho-beta Catenin/gamma Catenin (Tyr142, Tyr133) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143664-Each-of-1 | In Stock | ₹ 44,106.18 |
PIPA5143664 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,106.18
GST (18%): ₹ 7,939.112
Total Price: ₹ 52,045.292
Antigen
Phospho-beta Catenin/gamma Catenin (Tyr142, Tyr133)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CTNNB1
Gene Alias
Catenin beta1; CTNNB1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12387, 1499, 84353
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
P35222, Q02248, Q9WU82
Gene Symbols
CTNNB1
Immunogen
Phospho-beta-Catenin (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 142 of human beta-Catenin. This peptide sequence has one amino acid difference from a sequence around tyrosine 133 of human gamma-Catenin. These human sequences are highly conserved in rat and mouse beta- and gamma-Catenins.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose before affinity purification using phospho-beta-Catenin (Tyr-142) peptide (without carrier)
- The antibody detects a 92kDa* protein corresponding to the molecular mass of beta-Catenin on SDS-PAGE immunoblots of Hct116 src-transformed cells treated with pervanadate, but not in control cells
- Similar results were observed in pervanadate-treated A431 and human endothelial cells
- beta-Catenin is a 92 kDa protein that binds to the cytoplasmic tail of E-Cadherin
- The cadherins, transmembrane adhesion molecules, are found with catenins at adherens junctions
- Deletions in the cytoplasmic domain of E-Cadherin eliminate catenin binding and result in a loss of cell adhesion
- Tyrosine phosphorylation of beta-Catenin can regulate its interaction with critical components of adherens junctions
- Both Fer and Fyn kinases phosphorylate tyrosine 142 in vitro
- Overexpression of these kinases in epithelial cells disrupts interactions between alpha- and beta-Catenins
- The phosphorylation of tyrosine 142 may act as a switch from the transcriptional to the adhesive role of beta-Catenin
- Src family kinases can also phosphorylate tyrosine 86 and 654 in beta-Catenin
- The Tyr-654 phosphorylation regulates beta-Catenin binding to E-cadherin
- Thus, site-specific tyrosine phosphorylation of beta-Catenin may regulate protein-protein interactions leading to changes in cell adhesion.
Compare Similar Items
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Antigen: Phospho-beta Catenin/gamma Catenin (Tyr142, Tyr133)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTNNB1
Gene Alias: Catenin beta1; CTNNB1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12387, 1499, 84353
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P35222, Q02248, Q9WU82
Gene Symbols: CTNNB1
Immunogen: Phospho-beta-Catenin (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 142 of human beta-Catenin. This peptide sequence has one amino acid difference from a sequence around tyrosine 133 of human gamma-Catenin. These human sequences are highly conserved in rat and mouse beta- and gamma-Catenins.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-beta Catenin/gamma Catenin (Tyr142, Tyr133)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTNNB1
Gene Alias:
Catenin beta1; CTNNB1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12387, 1499, 84353
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P35222, Q02248, Q9WU82
Gene Symbols:
CTNNB1
Immunogen:
Phospho-beta-Catenin (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 142 of human beta-Catenin. This peptide sequence has one amino acid difference from a sequence around tyrosine 133 of human gamma-Catenin. These human sequences are highly conserved in rat and mouse beta- and gamma-Catenins.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: Phospho-beta Catenin/gamma Catenin (Tyr489, Tyr480)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTNNB1
Gene Alias: Catenin beta1; CTNNB1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12387, 1499, 84353
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P35222, Q02248, Q9WU82
Gene Symbols: CTNNB1
Immunogen: Phospho-beta-Catenin (Tyr-489) synthetic peptide corresponds to amino acid residues around tyrosine 489 of human beta-Catenin. This peptide sequence is highly conserved in rat and mouse beta-Catenin, and has high homology to the conserved site in gamma-Catenin (Tyr-480).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-beta Catenin/gamma Catenin (Tyr489, Tyr480)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTNNB1
Gene Alias:
Catenin beta1; CTNNB1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12387, 1499, 84353
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P35222, Q02248, Q9WU82
Gene Symbols:
CTNNB1
Immunogen:
Phospho-beta-Catenin (Tyr-489) synthetic peptide corresponds to amino acid residues around tyrosine 489 of human beta-Catenin. This peptide sequence is highly conserved in rat and mouse beta-Catenin, and has high homology to the conserved site in gamma-Catenin (Tyr-480).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: Phospho-beta Catenin/gamma Catenin (Tyr654, Tyr644)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CTNNB1
Gene Alias: Catenin beta1; CTNNB1
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12387, 1499, 84353
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: 0.25 mg/mL
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P35222, Q02248, Q9WU82
Gene Symbols: CTNNB1
Immunogen: Phospho-beta-Catenin (Tyr-654) synthetic peptide corresponds to amino acid residues around tyrosine 654 of human beta-Catenin. This peptide sequence is highly conserved in rat, mouse, chicken, and frog beta-Catenins, and has high homology to the conserved site in gamma-Catenin (Tyr-644).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-beta Catenin/gamma Catenin (Tyr654, Tyr644)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CTNNB1
Gene Alias:
Catenin beta1; CTNNB1
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12387, 1499, 84353
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
0.25 mg/mL
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P35222, Q02248, Q9WU82
Gene Symbols:
CTNNB1
Immunogen:
Phospho-beta-Catenin (Tyr-654) synthetic peptide corresponds to amino acid residues around tyrosine 654 of human beta-Catenin. This peptide sequence is highly conserved in rat, mouse, chicken, and frog beta-Catenins, and has high homology to the conserved site in gamma-Catenin (Tyr-644).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: Phospho-gamma Catenin (Tyr550)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: JUP
Gene Alias: ARVD12; catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; cb80; cell-adhesion protein plakoglobin; Ctnng; D930025P04Rik; danPG; Desmoplakin III; desmoplakin-3; desmosomal protein; DP3; DPIII; fb11b06; gama-catenin; gamma-catenin; gamma-catenin (plakoglobin); junction plakoglobin; junction plakoglobin a; Jup; jup protein; jupa; OTTHUMP00000164735; PDGB; PG; PKGB; plakoglobin; wu:fb11b06
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 16480, 3728, 81679
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG
Applications: Immunocytochemistry, Western Blot
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P14923, Q02257, Q6P0K8
Gene Symbols: JUP
Immunogen: Phospho-gamma-Catenin (Tyr-550) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 550 of human gamma-Catenin. This peptide sequence is highly conserved in rat and mouse gamma-Catenin.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
Phospho-gamma Catenin (Tyr550)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
JUP
Gene Alias:
ARVD12; catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; cb80; cell-adhesion protein plakoglobin; Ctnng; D930025P04Rik; danPG; Desmoplakin III; desmoplakin-3; desmosomal protein; DP3; DPIII; fb11b06; gama-catenin; gamma-catenin; gamma-catenin (plakoglobin); junction plakoglobin; junction plakoglobin a; Jup; jup protein; jupa; OTTHUMP00000164735; PDGB; PG; PKGB; plakoglobin; wu:fb11b06
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
16480, 3728, 81679
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG
Applications:
Immunocytochemistry, Western Blot
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P14923, Q02257, Q6P0K8
Gene Symbols:
JUP
Immunogen:
Phospho-gamma-Catenin (Tyr-550) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 550 of human gamma-Catenin. This peptide sequence is highly conserved in rat and mouse gamma-Catenin.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid